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Items: 1 to 20 of 77

1.

Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.

Beckham TH, Lu P, Cheng JC, Zhao D, Turner LS, Zhang X, Hoffman S, Armeson KE, Liu A, Marrison T, Hannun YA, Liu X.

Int J Cancer. 2012 Nov 1;131(9):2034-43. doi: 10.1002/ijc.27480. Epub 2012 Mar 27.

2.

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.

Morad SA, Levin JC, Tan SF, Fox TE, Feith DJ, Cabot MC.

Biochim Biophys Acta. 2013 Dec;1831(12):1657-64. doi: 10.1016/j.bbalip.2013.07.016. Epub 2013 Aug 9.

PMID:
23939396
3.

Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.

Beckham TH, Cheng JC, Lu P, Marrison ST, Norris JS, Liu X.

PLoS One. 2013 Oct 1;8(10):e76593. doi: 10.1371/journal.pone.0076593. eCollection 2013.

4.

Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer.

Mahdy AE, Cheng JC, Li J, Elojeimy S, Meacham WD, Turner LS, Bai A, Gault CR, McPherson AS, Garcia N, Beckham TH, Saad A, Bielawska A, Bielawski J, Hannun YA, Keane TE, Taha MI, Hammouda HM, Norris JS, Liu X.

Mol Ther. 2009 Mar;17(3):430-8. doi: 10.1038/mt.2008.281. Epub 2008 Dec 23.

5.

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.

Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR Jr, Bielawska A, Norris JS, Liu X.

J Clin Invest. 2013 Oct;123(10):4344-58. doi: 10.1172/JCI64791. Epub 2013 Sep 16.

6.

Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.

Turner LS, Cheng JC, Beckham TH, Keane TE, Norris JS, Liu X.

Prostate Cancer Prostatic Dis. 2011 Mar;14(1):30-7. doi: 10.1038/pcan.2010.47. Epub 2010 Nov 30.

7.

Matrigel invasion by the prostate cancer cell lines, PC3 and DU145, and cathepsin L+B activity.

Colella R, Jackson T, Goodwyn E.

Biotech Histochem. 2004 Jun-Aug;79(3-4):121-7.

PMID:
15621884
8.

Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.

Mizutani N, Inoue M, Omori Y, Ito H, Tamiya-Koizumi K, Takagi A, Kojima T, Nakamura M, Iwaki S, Nakatochi M, Suzuki M, Nozawa Y, Murate T.

J Biochem. 2015 Oct;158(4):309-19. doi: 10.1093/jb/mvv039. Epub 2015 Apr 17.

PMID:
25888580
9.

Acid ceramidase as a therapeutic target in metastatic prostate cancer.

Camacho L, Meca-Cortés O, Abad JL, García S, Rubio N, Díaz A, Celià-Terrassa T, Cingolani F, Bermudo R, Fernández PL, Blanco J, Delgado A, Casas J, Fabriàs G, Thomson TM.

J Lipid Res. 2013 May;54(5):1207-20. doi: 10.1194/jlr.M032375. Epub 2013 Feb 19.

10.

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION.

Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D.

J Biol Chem. 2016 Jan 29;291(5):2422-34. doi: 10.1074/jbc.M115.666909. Epub 2015 Nov 9.

11.
12.

ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype.

Smith AM, Findlay VJ, Bandurraga SG, Kistner-Griffin E, Spruill LS, Liu A, Golshayan AR, Turner DP.

Carcinogenesis. 2012 Mar;33(3):572-80. doi: 10.1093/carcin/bgs007. Epub 2012 Jan 9.

PMID:
22232738
13.

ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

Rafn B, Nielsen CF, Andersen SH, Szyniarowski P, Corcelle-Termeau E, Valo E, Fehrenbacher N, Olsen CJ, Daugaard M, Egebjerg C, Bøttzauw T, Kohonen P, Nylandsted J, Hautaniemi S, Moreira J, Jäättelä M, Kallunki T.

Mol Cell. 2012 Mar 30;45(6):764-76. doi: 10.1016/j.molcel.2012.01.029.

14.

Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.

Victor BC, Anbalagan A, Mohamed MM, Sloane BF, Cavallo-Medved D.

Breast Cancer Res. 2011;13(6):R115. doi: 10.1186/bcr3058. Epub 2011 Nov 17.

15.

Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.

Xu R, Sun W, Jin J, Obeid LM, Mao C.

FASEB J. 2010 Jul;24(7):2507-15. doi: 10.1096/fj.09-153635. Epub 2010 Mar 5.

16.

Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.

Ohotski J, Edwards J, Elsberger B, Watson C, Orange C, Mallon E, Pyne S, Pyne NJ.

Int J Cancer. 2013 Feb 1;132(3):605-16. doi: 10.1002/ijc.27692. Epub 2012 Jul 11.

17.

mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate.

Wang FX, Dong ZR, Liu ZL, Pan L, Luo JM, Zhang XJ, Hao HL, Li XL, Yang JC, Jiang LL.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):577-83.

PMID:
15498114
18.

An intracellular form of cathepsin B contributes to invasiveness in cancer.

Szpaderska AM, Frankfater A.

Cancer Res. 2001 Apr 15;61(8):3493-500.

19.

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.

Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS.

Expert Opin Ther Targets. 2009 Dec;13(12):1449-58. doi: 10.1517/14728220903357512. Review.

20.

ETS1 promotes chemoresistance and invasion of paclitaxel-resistant, hormone-refractory PC3 prostate cancer cells by up-regulating MDR1 and MMP9 expression.

Kato T, Fujita Y, Nakane K, Kojima T, Nozawa Y, Deguchi T, Ito M.

Biochem Biophys Res Commun. 2012 Jan 20;417(3):966-71. doi: 10.1016/j.bbrc.2011.12.047. Epub 2011 Dec 20.

PMID:
22206665

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