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Items: 1 to 20 of 130

1.

Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease.

Di Domenico F, Sultana R, Ferree A, Smith K, Barone E, Perluigi M, Coccia R, Pierce W, Cai J, Mancuso C, Squillace R, Wiengele M, Dalle-Donne I, Wolozin B, Butterfield DA.

Antioxid Redox Signal. 2012 Dec 1;17(11):1490-506. Epub 2012 Mar 20.

2.

Regulation of physiologic actions of LRRK2: focus on autophagy.

Ferree A, Guillily M, Li H, Smith K, Takashima A, Squillace R, Weigele M, Collins JJ, Wolozin B.

Neurodegener Dis. 2012;10(1-4):238-41. doi: 10.1159/000332599. Epub 2011 Dec 23.

3.

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.

Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, Zhu X, Smith MA, Wilson-Delfosse AL, Chen SG.

Neurobiol Dis. 2010 Oct;40(1):73-81. doi: 10.1016/j.nbd.2010.04.002. Epub 2010 Apr 9.

4.

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.

Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H, Wilson-Delfosse AL, Chen SG.

Hum Mol Genet. 2013 Jan 15;22(2):328-44. doi: 10.1093/hmg/dds431. Epub 2012 Oct 12.

5.

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.

Plowey ED, Cherra SJ 3rd, Liu YJ, Chu CT.

J Neurochem. 2008 May;105(3):1048-56. doi: 10.1111/j.1471-4159.2008.05217.x. Epub 2008 Jan 7.

6.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M.

Hum Mol Genet. 2016 Dec 15;25(24):5365-5382. doi: 10.1093/hmg/ddw352.

PMID:
27794539
7.

Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression.

Liu G, Sgobio C, Gu X, Sun L, Lin X, Yu J, Parisiadou L, Xie C, Sastry N, Ding J, Lohr KM, Miller GW, Mateo Y, Lovinger DM, Cai H.

Hum Mol Genet. 2015 Sep 15;24(18):5299-312. doi: 10.1093/hmg/ddv249. Epub 2015 Jun 29.

8.

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation.

Su YC, Qi X.

Hum Mol Genet. 2013 Nov 15;22(22):4545-61. doi: 10.1093/hmg/ddt301. Epub 2013 Jun 27.

PMID:
23813973
9.

Investigating convergent actions of genes linked to familial Parkinson's disease.

Wolozin B, Saha S, Guillily M, Ferree A, Riley M.

Neurodegener Dis. 2008;5(3-4):182-5. doi: 10.1159/000113697. Epub 2008 Mar 6.

10.

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.

Wang X, Yan MH, Fujioka H, Liu J, Wilson-Delfosse A, Chen SG, Perry G, Casadesus G, Zhu X.

Hum Mol Genet. 2012 May 1;21(9):1931-44. doi: 10.1093/hmg/dds003. Epub 2012 Jan 6.

11.

LRRK2 Facilitates tau Phosphorylation through Strong Interaction with tau and cdk5.

Shanley MR, Hawley D, Leung S, Zaidi NF, Dave R, Schlosser KA, Bandopadhyay R, Gerber SA, Liu M.

Biochemistry. 2015 Aug 25;54(33):5198-208. doi: 10.1021/acs.biochem.5b00326. Epub 2015 Aug 13.

PMID:
26268594
12.

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

Lin CH, Tsai PI, Wu RM, Chien CT.

J Neurosci. 2010 Sep 29;30(39):13138-49. doi: 10.1523/JNEUROSCI.1737-10.2010.

13.

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease.

Tsika E, Nguyen AP, Dusonchet J, Colin P, Schneider BL, Moore DJ.

Neurobiol Dis. 2015 May;77:49-61. doi: 10.1016/j.nbd.2015.02.019. Epub 2015 Feb 28.

PMID:
25731749
14.

Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.

Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI.

J Neurosci Res. 2015 Oct;93(10):1567-80. doi: 10.1002/jnr.23614. Epub 2015 Jun 30.

15.

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.

Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, Cooper JM.

Hum Mol Genet. 2012 Oct 1;21(19):4201-13. doi: 10.1093/hmg/dds244. Epub 2012 Jun 26.

16.

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

Dusonchet J, Kochubey O, Stafa K, Young SM Jr, Zufferey R, Moore DJ, Schneider BL, Aebischer P.

J Neurosci. 2011 Jan 19;31(3):907-12. doi: 10.1523/JNEUROSCI.5092-10.2011.

17.

LRRK2 I2020T mutation is associated with tau pathology.

Ujiie S, Hatano T, Kubo S, Imai S, Sato S, Uchihara T, Yagishita S, Hasegawa K, Kowa H, Sakai F, Hattori N.

Parkinsonism Relat Disord. 2012 Aug;18(7):819-23. doi: 10.1016/j.parkreldis.2012.03.024. Epub 2012 Apr 22.

PMID:
22525366
18.

Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.

Lin CH, Lin HI, Chen ML, Lai TT, Cao LP, Farrer MJ, Wu RM, Chien CT.

Hum Mol Genet. 2016 May 15;25(10):1965-1978. Epub 2016 Feb 29.

PMID:
26931464
19.

[Clinical features of LRRK2-associated Parkinson's disease].

Pchelina SN, Ivanova ON, Emel'ianov AK, Iakimovskiĭ AF.

Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(12):56-62. Russian.

PMID:
22433811
20.

Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.

Floris G, Cannas A, Solla P, Murru MR, Tranquilli S, Corongiu D, Rolesu M, Cuccu S, Sardu C, Marrosu F, Marrosu MG.

Parkinsonism Relat Disord. 2009 May;15(4):277-80. doi: 10.1016/j.parkreldis.2008.06.009. Epub 2008 Sep 20.

PMID:
18805725

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