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Items: 1 to 20 of 101

1.

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.

Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78. doi: 10.1073/pnas.1115623109. Epub 2012 Feb 6.

2.

Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress.

Bright MD, Itzhak DN, Wardell CP, Morgan GJ, Davies FE.

Mol Cell Biol. 2015 Jun;35(12):2186-202. doi: 10.1128/MCB.00013-15. Epub 2015 Apr 13.

3.

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.

Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.

J Biol Chem. 2011 Apr 8;286(14):12743-55. doi: 10.1074/jbc.M110.199737. Epub 2011 Feb 8.

4.

Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status.

Moore K, Hollien J.

Mol Biol Cell. 2015 Aug 15;26(16):2873-84. doi: 10.1091/mbc.E15-02-0074. Epub 2015 Jun 24.

5.

PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1.

Eletto D, Eletto D, Boyle S, Argon Y.

FASEB J. 2016 Feb;30(2):653-65. doi: 10.1096/fj.15-275883. Epub 2015 Oct 20.

6.

Acute Endoplasmic Reticulum Stress-Independent Unconventional Splicing of XBP1 mRNA in the Nucleus of Mammalian Cells.

Wang Y, Xing P, Cui W, Wang W, Cui Y, Ying G, Wang X, Li B.

Int J Mol Sci. 2015 Jun 10;16(6):13302-21. doi: 10.3390/ijms160613302.

7.

Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response.

Tardif KD, Mori K, Kaufman RJ, Siddiqui A.

J Biol Chem. 2004 Apr 23;279(17):17158-64. Epub 2004 Feb 11.

8.

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A, McAndrews C, Rowlands MG, Morgan GJ, Aherne W, Collins I, Davies FE, Pearl LH.

EMBO J. 2011 Mar 2;30(5):894-905. doi: 10.1038/emboj.2011.18. Epub 2011 Feb 11.

9.
10.

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D.

Nature. 2002 Jan 3;415(6867):92-6. Erratum in: Nature 2002 Nov 14;420(6912):202.

PMID:
11780124
11.

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival.

Walter F, Schmid J, Düssmann H, Concannon CG, Prehn JH.

Cell Death Differ. 2015 Sep;22(9):1502-16. doi: 10.1038/cdd.2014.241. Epub 2015 Jan 30.

12.

Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress.

Back SH, Lee K, Vink E, Kaufman RJ.

J Biol Chem. 2006 Jul 7;281(27):18691-706. Epub 2006 Apr 27.

13.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.

Blood. 2012 Jun 14;119(24):5772-81. doi: 10.1182/blood-2011-07-366633. Epub 2012 Apr 26.

14.

Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish.

Ishikawa T, Kashima M, Nagano AJ, Ishikawa-Fujiwara T, Kamei Y, Todo T, Mori K.

Elife. 2017 Sep 27;6. pii: e26845. doi: 10.7554/eLife.26845.

15.

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing.

Peschek J, Acosta-Alvear D, Mendez AS, Walter P.

EMBO Rep. 2015 Dec;16(12):1688-98. doi: 10.15252/embr.201540955. Epub 2015 Oct 19.

16.

ER stress signaling by regulated splicing: IRE1/HAC1/XBP1.

Back SH, Schröder M, Lee K, Zhang K, Kaufman RJ.

Methods. 2005 Apr;35(4):395-416.

PMID:
15804613
17.

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response.

Uemura A, Oku M, Mori K, Yoshida H.

J Cell Sci. 2009 Aug 15;122(Pt 16):2877-86. doi: 10.1242/jcs.040584. Epub 2009 Jul 21.

18.

Ire1 has distinct catalytic mechanisms for XBP1/HAC1 splicing and RIDD.

Tam AB, Koong AC, Niwa M.

Cell Rep. 2014 Nov 6;9(3):850-8. doi: 10.1016/j.celrep.2014.09.016. Epub 2014 Oct 30.

19.

Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

Rong J, Pass I, Diaz PW, Ngo TA, Sauer M, Magnuson G, Zeng FY, Hassig CA, Jackson MR, Cosford ND, Matsuzawa S, Reed JC.

J Biomol Screen. 2015 Dec;20(10):1232-45. doi: 10.1177/1087057115600414. Epub 2015 Aug 11.

PMID:
26265713
20.

Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.

Lee R, Xu B, Rame JE, Felkin LE, Barton P, Dries DL.

J Am Heart Assoc. 2014 Dec;3(6):e001104. doi: 10.1161/JAHA.114..

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