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Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells.

Obanda DN, Hernandez A, Ribnicky D, Yu Y, Zhang XH, Wang ZQ, Cefalu WT.

Diabetes. 2012 Mar;61(3):597-605. doi: 10.2337/db11-0396. Epub 2012 Feb 7.


Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.

Obanda DN, Ribnicky DM, Raskin I, Cefalu WT.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S59-66. doi: 10.1016/j.nut.2014.03.006. Epub 2014 Mar 19.


Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells.

Obanda DN, Cefalu WT.

J Nutr Biochem. 2013 Aug;24(8):1529-37. doi: 10.1016/j.jnutbio.2012.12.014. Epub 2013 Mar 6.


Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture.

Wang ZQ, Ribnicky D, Zhang XH, Raskin I, Yu Y, Cefalu WT.

Metabolism. 2008 Jul;57(7 Suppl 1):S58-64. doi: 10.1016/j.metabol.2008.04.003.


A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids.

Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA.

J Biol Chem. 2003 Mar 21;278(12):10297-303. Epub 2003 Jan 13.


Artemisia dracunculus L. extract ameliorates insulin sensitivity by attenuating inflammatory signalling in human skeletal muscle culture.

Vandanmagsar B, Haynie KR, Wicks SE, Bermudez EM, Mendoza TM, Ribnicky D, Cefalu WT, Mynatt RL.

Diabetes Obes Metab. 2014 Aug;16(8):728-38. doi: 10.1111/dom.12274. Epub 2014 Mar 10.


An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.

Wang ZQ, Ribnicky D, Zhang XH, Zuberi A, Raskin I, Yu Y, Cefalu WT.

J Nutr Biochem. 2011 Jan;22(1):71-8. doi: 10.1016/j.jnutbio.2009.11.015. Epub 2010 May 5.


Stinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner.

Obanda DN, Zhao P, Richard AJ, Ribnicky D, Cefalu WT, Stephens JM.

PLoS One. 2016 Mar 3;11(3):e0150252. doi: 10.1371/journal.pone.0150252. eCollection 2016.


Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation.

Kheterpal I, Scherp P, Kelley L, Wang Z, Johnson W, Ribnicky D, Cefalu WT.

Nutrition. 2014 Jul-Aug;30(7-8 Suppl):S43-51. doi: 10.1016/j.nut.2014.05.001. Epub 2014 May 13.


Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight.

Mahfouz R, Khoury R, Blachnio-Zabielska A, Turban S, Loiseau N, Lipina C, Stretton C, Bourron O, Ferré P, Foufelle F, Hundal HS, Hajduch E.

PLoS One. 2014 Jul 24;9(7):e101865. doi: 10.1371/journal.pone.0101865. eCollection 2014.


Ceramide-activated protein phosphatase involvement in insulin resistance via Akt, serine/arginine-rich protein 40, and ribonucleic acid splicing in L6 skeletal muscle cells.

Ghosh N, Patel N, Jiang K, Watson JE, Cheng J, Chalfant CE, Cooper DR.

Endocrinology. 2007 Mar;148(3):1359-66. Epub 2006 Dec 7.


Ceramides inhibit phospholipase D-dependent insulin signaling in liver cells of old rats.

Babenko NA, Kharchenko VS.

Biochemistry (Mosc). 2012 Feb;77(2):180-6. doi: 10.1134/S0006297912020095.


Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE.

Hage Hassan R, Pacheco de Sousa AC, Mahfouz R, Hainault I, Blachnio-Zabielska A, Bourron O, Koskas F, Górski J, Ferré P, Foufelle F, Hajduch E.

J Biol Chem. 2016 Feb 5;291(6):3019-29. doi: 10.1074/jbc.M115.686949. Epub 2015 Dec 23.


Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance.

Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1341-50. Epub 2006 Jul 18.


Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment.

Frangioudakis G, Diakanastasis B, Liao BQ, Saville JT, Hoffman NJ, Mitchell TW, Schmitz-Peiffer C.

Diabetologia. 2013 Dec;56(12):2697-701. doi: 10.1007/s00125-013-3035-5. Epub 2013 Aug 29.


An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A).

Obanda DN, Ribnicky D, Yu Y, Stephens J, Cefalu WT.

Sci Rep. 2016 Feb 26;6:22222. doi: 10.1038/srep22222.


Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.

Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA.

J Biol Chem. 2005 May 20;280(20):20148-53. Epub 2005 Mar 17.


Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ.

Diabetes. 2004 Jan;53(1):25-31.

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