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Items: 1 to 20 of 106

1.

MK-4815, a potential new oral agent for treatment of malaria.

Powles MA, Allocco J, Yeung L, Nare B, Liberator P, Schmatz D.

Antimicrob Agents Chemother. 2012 May;56(5):2414-9. doi: 10.1128/AAC.05326-11. Epub 2012 Feb 6.

2.

Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro.

Sáenz FE, Mutka T, Udenze K, Oduola AM, Kyle DE.

Antimicrob Agents Chemother. 2012 Sep;56(9):4685-92. doi: 10.1128/AAC.01061-12. Epub 2012 Jun 18.

3.

Curcumin for malaria therapy.

Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN.

Biochem Biophys Res Commun. 2005 Jan 14;326(2):472-4.

PMID:
15582601
4.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.

Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, Sanz L, Jiménez-Díaz B, Angulo-Barturen I, Ferrer S, Martínez MS, Gamo FJ, Frearson JA, Gray DW, Fairlamb AH, Winzeler EA, Waterson D, Campbell SF, Willis P, Read KD, Gilbert IH.

J Med Chem. 2016 Jul 14;59(13):6101-20. doi: 10.1021/acs.jmedchem.6b00028. Epub 2016 Jun 17.

5.

Protective activity of biflavanones from Garcinia kola against Plasmodium infection.

Konziase B.

J Ethnopharmacol. 2015 Aug 22;172:214-8. doi: 10.1016/j.jep.2015.06.038. Epub 2015 Jun 27.

PMID:
26129936
6.

Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.

de Sá MS, Costa JF, Krettli AU, Zalis MG, Maia GL, Sette IM, Câmara Cde A, Filho JM, Giulietti-Harley AM, Ribeiro Dos Santos R, Soares MB.

Parasitol Res. 2009 Jul;105(1):275-9. doi: 10.1007/s00436-009-1394-0. Epub 2009 Apr 15.

PMID:
19367418
7.

Bioassay-guided isolation and characterization of active antiplasmodial compounds from Murraya koenigii extracts against Plasmodium falciparum and Plasmodium berghei.

Kamaraj C, Rahuman AA, Roopan SM, Bagavan A, Elango G, Zahir AA, Rajakumar G, Jayaseelan C, Santhoshkumar T, Marimuthu S, Kirthi AV.

Parasitol Res. 2014 May;113(5):1657-72. doi: 10.1007/s00436-014-3810-3. Epub 2014 Mar 18.

PMID:
24638906
8.

New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.

Soares RR, da Silva JM, Carlos BC, da Fonseca CC, de Souza LS, Lopes FV, de Paula Dias RM, Moreira PO, Abramo C, Viana GH, de Pila Varotti F, da Silva AD, Scopel KK.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2308-13. doi: 10.1016/j.bmcl.2015.04.014. Epub 2015 Apr 11.

PMID:
25920564
9.

Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.

Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA.

Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936. Epub 2011 Nov 17.

10.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

11.

In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.

Wittlin S, Ekland E, Craft JC, Lotharius J, Bathurst I, Fidock DA, Fernandes P.

Antimicrob Agents Chemother. 2012 Feb;56(2):703-7. doi: 10.1128/AAC.05039-11. Epub 2011 Nov 14.

12.

Antimalarial efficacy of hydroxyethylapoquinine (SN-119) and its derivatives.

Sanders NG, Meyers DJ, Sullivan DJ.

Antimicrob Agents Chemother. 2014;58(2):820-7. doi: 10.1128/AAC.01704-13. Epub 2013 Nov 18.

13.

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium.

Birrell GW, Chavchich M, Ager AL, Shieh HM, Heffernan GD, Zhao W, Krasucki PE, Saionz KW, Terpinski J, Schiehser GA, Jacobus LR, Shanks GD, Jacobus DP, Edstein MD.

Antimicrob Agents Chemother. 2015 Jan;59(1):170-7. doi: 10.1128/AAC.03762-14. Epub 2014 Oct 20.

14.

Repositioning: the fast track to new anti-malarial medicines?

Lotharius J, Gamo-Benito FJ, Angulo-Barturen I, Clark J, Connelly M, Ferrer-Bazaga S, Parkinson T, Viswanath P, Bandodkar B, Rautela N, Bharath S, Duffy S, Avery VM, Möhrle JJ, Guy RK, Wells T.

Malar J. 2014 Apr 14;13:143. doi: 10.1186/1475-2875-13-143.

15.

Identification of a new chemical class of antimalarials.

Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, Delahaye S, Fischli C, Heidmann B, Kaiser M, Kamber J, Meyer S, Papastogiannidis P, Siegrist R, Voss T, Welford R, Wittlin S, Binkert C.

J Infect Dis. 2012 Sep 1;206(5):735-43. doi: 10.1093/infdis/jis418. Epub 2012 Jun 25.

PMID:
22732921
17.

In vitro and in vivo properties of ellagic acid in malaria treatment.

Soh PN, Witkowski B, Olagnier D, Nicolau ML, Garcia-Alvarez MC, Berry A, Benoit-Vical F.

Antimicrob Agents Chemother. 2009 Mar;53(3):1100-6. doi: 10.1128/AAC.01175-08. Epub 2008 Nov 17.

18.

In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine.

Kimura A, Nishikawa H, Nomura N, Mitsuyama J, Fukumoto S, Inoue N, Kawazu S.

Antimicrob Agents Chemother. 2012 Apr;56(4):2191-3. doi: 10.1128/AAC.05856-11. Epub 2012 Jan 17.

19.

In vitro and in vivo anti-malarial activity of tigecycline, a glycylcycline antibiotic, in combination with chloroquine.

Sahu R, Walker LA, Tekwani BL.

Malar J. 2014 Oct 21;13:414. doi: 10.1186/1475-2875-13-414.

20.

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.

Schleiferböck S, Scheurer C, Ihara M, Itoh I, Bathurst I, Burrows JN, Fantauzzi P, Lotharius J, Charman SA, Morizzi J, Shackleford DM, White KL, Brun R, Wittlin S.

Drug Des Devel Ther. 2013 Nov 15;7:1377-84. doi: 10.2147/DDDT.S51298. eCollection 2013.

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