Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 135

1.

Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates.

Kashiwazaki G, Bando T, Yoshidome T, Masui S, Takagaki T, Hashiya K, Pandian GN, Yasuoka J, Akiyoshi K, Sugiyama H.

J Med Chem. 2012 Mar 8;55(5):2057-66. doi: 10.1021/jm201225z. Epub 2012 Feb 17.

PMID:
22309169
2.

Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation.

Takagaki T, Bando T, Kitano M, Hashiya K, Kashiwazaki G, Sugiyama H.

Bioorg Med Chem. 2011 Oct 1;19(19):5896-902. doi: 10.1016/j.bmc.2011.08.009. Epub 2011 Aug 16.

PMID:
21903400
3.

Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI.

Minoshima M, Bando T, Shinohara K, Kashiwazaki G, Nishijima S, Sugiyama H.

Bioorg Med Chem. 2010 Feb;18(3):1236-43. doi: 10.1016/j.bmc.2009.12.033. Epub 2009 Dec 21.

PMID:
20074970
4.

Synthesis and biological properties of pyrrole-imidazole polyamide conjugates.

Minoshima M, Sasaki S, Fujimoto J, Shinohara K, Bando T, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2007;(51):35-6.

PMID:
18029573
5.

C-H to N substitution dramatically alters the sequence-specific DNA alkylation, cytotoxicity, and expression of human cancer cell lines.

Bando T, Narita A, Iwai A, Kihara K, Sugiyama H.

J Am Chem Soc. 2004 Mar 24;126(11):3406-7.

PMID:
15025451
6.
7.

Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.

Minoshima M, Chou JC, Lefebvre S, Bando T, Shinohara K, Gottesfeld JM, Sugiyama H.

Bioorg Med Chem. 2010 Jan 1;18(1):168-74. doi: 10.1016/j.bmc.2009.11.005. Epub 2009 Nov 11.

PMID:
19962902
8.

Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides.

Bando T, Sugiyama H.

Acc Chem Res. 2006 Dec;39(12):935-44. Review.

PMID:
17176032
9.

Synthesis and evaluation of sequence-specific DNA alkylating agents: effect of alkylation subunits.

Shimizu T, Sasaki S, Minoshima M, Shinohara K, Bando T, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2006;(50):155-6.

PMID:
17150864
10.

Molecular design of sequence specific DNA alkylating agents.

Minoshima M, Bando T, Shinohara K, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2009;(53):69-70. doi: 10.1093/nass/nrp035.

PMID:
19749264
11.

Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition.

Shinohara K, Bando T, Sugiyama H.

Anticancer Drugs. 2010 Mar;21(3):228-42. doi: 10.1097/CAD.0b013e328334d8f9. Review.

PMID:
20038830
12.

Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction.

Kashiwazaki G, Bando T, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2008;(52):365-6. doi: 10.1093/nass/nrn184.

PMID:
18776405
13.

Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide.

Takahashi R, Bando T, Sugiyama H.

Bioorg Med Chem. 2003 Jun 12;11(12):2503-9.

PMID:
12757718
14.

Synthesis of pyrrole-imidazole polyamide seco-1-chloromethyl-5-hydroxy-1,2-dihydro-3h-benz[e]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence.

Takagaki T, Bando T, Sugiyama H.

J Am Chem Soc. 2012 Aug 8;134(31):13074-81. doi: 10.1021/ja3044294. Epub 2012 Jul 25.

PMID:
22799887
15.

Targeting specific gene by alkylating pyrrole-imidazole polyamides.

Minoshima M, Chou J, Lefebvre S, Bando T, Shinohara K, Gottesfeld JM, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2008;(52):363-4. doi: 10.1093/nass/nrn183.

PMID:
18776404
16.

Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design.

Kashiwazaki G, Bando T, Shinohara K, Minoshima M, Nishijima S, Sugiyama H.

Bioorg Med Chem. 2009 Feb 1;17(3):1393-7. doi: 10.1016/j.bmc.2008.12.019. Epub 2008 Dec 24.

PMID:
19124249
17.

Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: sequence-specific alkylation with nine-base-pair recognition.

Bando T, Sasaki S, Minoshima M, Dohno C, Shinohara K, Narita A, Sugiyama H.

Bioconjug Chem. 2006 May-Jun;17(3):715-20.

PMID:
16704209
18.

Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates.

Kashiwazaki G, Bando T, Shinohara K, Minoshima M, Kumamoto H, Nishijima S, Sugiyama H.

Bioorg Med Chem. 2010 Apr 15;18(8):2887-93. doi: 10.1016/j.bmc.2010.03.011. Epub 2010 Mar 10.

PMID:
20350810
19.

Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides.

Bando T, Iida H, Tao ZF, Narita A, Fukuda N, Yamori T, Sugiyama H.

Chem Biol. 2003 Aug;10(8):751-8.

20.

Sequence-specific alkylation by a tandem motif of pyrrole-imidazole CBI conjugate.

Sasaki S, Minoshima M, Fujimoto J, Shinohara K, Bando T, Sugiyama H.

Nucleic Acids Symp Ser (Oxf). 2007;(51):265-6.

PMID:
18029688

Supplemental Content

Support Center