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Items: 1 to 20 of 104

1.

Amphotericin primarily kills yeast by simply binding ergosterol.

Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17.

2.

Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities.

Palacios DS, Dailey I, Siebert DM, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6733-8. doi: 10.1073/pnas.1015023108. Epub 2011 Feb 28.

3.

Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae.

Kang CK, Yamada K, Usuki Y, Ogita A, Fujita K, Tanaka T.

Microbiology. 2013 May;159(Pt 5):939-47. doi: 10.1099/mic.0.065714-0. Epub 2013 Mar 8.

PMID:
23475946
4.

Amphotericin forms an extramembranous and fungicidal sterol sponge.

Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD.

Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30.

5.

Enhancement of the fungicidal activity of amphotericin B by allicin: effects on intracellular ergosterol trafficking.

Ogita A, Fujita K, Tanaka T.

Planta Med. 2009 Feb;75(3):222-6. doi: 10.1055/s-0028-1088376. Epub 2008 Dec 3.

PMID:
19053016
6.

Amphotericin B covalent dimers forming sterol-dependent ion-permeable membrane channels.

Matsumori N, Yamaji N, Matsuoka S, Oishi T, Murata M.

J Am Chem Soc. 2002 Apr 24;124(16):4180-1.

PMID:
11960425
7.

Dependence of vacuole disruption and independence of potassium ion efflux in fungicidal activity induced by combination of amphotericin B and allicin against Saccharomyces cerevisiae.

Ogita A, Yutani M, Fujita K, Tanaka T.

J Antibiot (Tokyo). 2010 Dec;63(12):689-92. doi: 10.1038/ja.2010.115. Epub 2010 Oct 13.

PMID:
20940723
8.

Direct interaction between amphotericin B and ergosterol in lipid bilayers as revealed by 2H NMR spectroscopy.

Matsumori N, Tahara K, Yamamoto H, Morooka A, Doi M, Oishi T, Murata M.

J Am Chem Soc. 2009 Aug 26;131(33):11855-60. doi: 10.1021/ja9033473.

PMID:
19645473
9.

C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.

Wilcock BC, Endo MM, Uno BE, Burke MD.

J Am Chem Soc. 2013 Jun 12;135(23):8488-91. doi: 10.1021/ja403255s. Epub 2013 Jun 3.

10.

Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.

Shimizu K, Osada M, Takemoto K, Yamamoto Y, Asai T, Oku N.

J Control Release. 2010 Jan 25;141(2):208-15. doi: 10.1016/j.jconrel.2009.09.019. Epub 2009 Oct 6.

PMID:
19815038
11.

The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.

Mesa-Arango AC, Trevijano-Contador N, Román E, Sánchez-Fresneda R, Casas C, Herrero E, Argüelles JC, Pla J, Cuenca-Estrella M, Zaragoza O.

Antimicrob Agents Chemother. 2014 Nov;58(11):6627-38. doi: 10.1128/AAC.03570-14. Epub 2014 Aug 25.

12.

How do sterols determine the antifungal activity of amphotericin B? Free energy of binding between the drug and its membrane targets.

Neumann A, Baginski M, Czub J.

J Am Chem Soc. 2010 Dec 29;132(51):18266-72. doi: 10.1021/ja1074344. Epub 2010 Dec 2.

PMID:
21126070
13.

Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.

Hull CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2012 Aug;56(8):4223-32. doi: 10.1128/AAC.06253-11. Epub 2012 May 21.

14.

Fluorescence studies on the molecular action of amphotericin B on susceptible and resistant fungal cells.

Haynes MP, Chong PL, Buckley HR, Pieringer RA.

Biochemistry. 1996 Jun 18;35(24):7983-92.

PMID:
8672502
16.

Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis.

Masuda A, Akiyama S, Kuwano M, Ikekawa N.

J Antibiot (Tokyo). 1982 Feb;35(2):230-4.

17.

On the role of sterol in the formation of the amphotericin B channel.

Cotero BV, Rebolledo-Antúnez S, Ortega-Blake I.

Biochim Biophys Acta. 1998 Oct 15;1375(1-2):43-51.

PMID:
9767100
18.
19.

The vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin.

Borjihan H, Ogita A, Fujita K, Hirasawa E, Tanaka T.

J Antibiot (Tokyo). 2009 Dec;62(12):691-7. doi: 10.1038/ja.2009.103. Epub 2009 Oct 30.

PMID:
19876074
20.

Lipid polyunsaturation determines the extent of membrane structural changes induced by Amphotericin B in Pichia pastoris yeast.

de Ghellinck A, Fragneto G, Laux V, Haertlein M, Jouhet J, Sferrazza M, Wacklin H.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2317-25. doi: 10.1016/j.bbamem.2015.06.006. Epub 2015 Jun 6.

PMID:
26055896
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