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Items: 1 to 20 of 190

1.

Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.

Ketron AC, Denny WA, Graves DE, Osheroff N.

Biochemistry. 2012 Feb 28;51(8):1730-9. doi: 10.1021/bi201159b. Epub 2012 Feb 10.

2.

Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.

Infante Lara L, Sledge A, Laradji A, Okoro CO, Osheroff N.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):586-589. doi: 10.1016/j.bmcl.2016.12.011. Epub 2016 Dec 5.

PMID:
27998679
3.

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.

Zwelling LA, Mayes J, Hinds M, Chan D, Altschuler E, Carroll B, Parker E, Deisseroth K, Radcliffe A, Seligman M, et al.

Biochemistry. 1991 Apr 23;30(16):4048-55.

PMID:
1850298
4.

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs.

Wu CC, Li YC, Wang YR, Li TK, Chan NL.

Nucleic Acids Res. 2013 Dec;41(22):10630-40. doi: 10.1093/nar/gkt828. Epub 2013 Sep 14.

5.

Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.

Zwelling LA, Hinds M, Chan D, Mayes J, Sie KL, Parker E, Silberman L, Radcliffe A, Beran M, Blick M.

J Biol Chem. 1989 Oct 5;264(28):16411-20.

9.
11.

Intercalator-induced, topoisomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites.

Zwelling LA, Silberman L, Estey E.

Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1041-7. Review.

PMID:
2427489
13.

Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison.

Godbole AA, Ahmed W, Bhat RS, Bradley EK, Ekins S, Nagaraja V.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):916-20. doi: 10.1016/j.bbrc.2014.03.029. Epub 2014 Mar 15.

PMID:
24642256
14.
17.

The production of topoisomerase II-mediated DNA cleavage in human leukemia cells predicts their susceptibility to 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA).

Bakic M, Beran M, Andersson BS, Silberman L, Estey E, Zwelling LA.

Biochem Biophys Res Commun. 1986 Jan 29;134(2):638-45.

PMID:
3004458
18.

Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol.

Yamashita Y, Kawada S, Nakano H.

Biochem Pharmacol. 1990 Feb 15;39(4):737-44.

PMID:
2154993
19.

Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.

Lindsey RH Jr, Pendleton M, Ashley RE, Mercer SL, Deweese JE, Osheroff N.

Biochemistry. 2014 Oct 21;53(41):6595-602. doi: 10.1021/bi5010816. Epub 2014 Oct 10.

20.

Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol.

Adlakha RC, Ashorn CL, Chan D, Zwelling LA.

Cancer Res. 1989 Apr 15;49(8):2052-8. Erratum in: Cancer Res 1989 Jun 1;49(11):3142.

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