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Items: 1 to 20 of 140

1.

Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

Shahi P, Park D, Pond AC, Seethammagari M, Chiou SH, Cho K, Carstens JL, Decker WK, McCrea PD, Ittmann MM, Rosen JM, Spencer DM.

PLoS One. 2012;7(1):e30814. doi: 10.1371/journal.pone.0030814. Epub 2012 Jan 27.

2.

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

MacDonald BT, Semenov MV, Huang H, He X.

PLoS One. 2011;6(8):e23537. doi: 10.1371/journal.pone.0023537. Epub 2011 Aug 24.

3.

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.

Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8032-7. doi: 10.1073/pnas.0803025105. Epub 2008 May 28.

4.

Coordinated action of CK1 isoforms in canonical Wnt signaling.

Del Valle-Pérez B, Arqués O, Vinyoles M, de Herreros AG, Duñach M.

Mol Cell Biol. 2011 Jul;31(14):2877-88. doi: 10.1128/MCB.01466-10. Epub 2011 May 23.

5.

Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway.

Hay E, Faucheu C, Suc-Royer I, Touitou R, Stiot V, Vayssière B, Baron R, Roman-Roman S, Rawadi G.

J Biol Chem. 2005 Apr 8;280(14):13616-23. Epub 2005 Feb 7.

6.

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Goel S, Chin EN, Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM.

J Biol Chem. 2012 May 11;287(20):16454-66. doi: 10.1074/jbc.M112.362137. Epub 2012 Mar 20.

7.

LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells.

Peröbner I, Karow M, Jochum M, Neth P.

Int J Biochem Cell Biol. 2012 Nov;44(11):1970-82. doi: 10.1016/j.biocel.2012.07.025. Epub 2012 Aug 2.

PMID:
22871567
8.

Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.

Haÿ E, Buczkowski T, Marty C, Da Nascimento S, Sonnet P, Marie PJ.

J Bone Miner Res. 2012 Sep;27(9):1852-63. doi: 10.1002/jbmr.1656.

9.
10.

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway.

Lu W, Lin C, Roberts MJ, Waud WR, Piazza GA, Li Y.

PLoS One. 2011;6(12):e29290. doi: 10.1371/journal.pone.0029290. Epub 2011 Dec 16.

11.

Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.

Nagaoka T, Karasawa H, Turbyville T, Rangel MC, Castro NP, Gonzales M, Baker A, Seno M, Lockett S, Greer YE, Rubin JS, Salomon DS, Bianco C.

Cell Signal. 2013 Jan;25(1):178-89. doi: 10.1016/j.cellsig.2012.09.024. Epub 2012 Sep 27.

12.

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.

Haÿ E, Laplantine E, Geoffroy V, Frain M, Kohler T, Müller R, Marie PJ.

Mol Cell Biol. 2009 Feb;29(4):953-64. doi: 10.1128/MCB.00349-08. Epub 2008 Dec 15.

13.

Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex.

Koyama-Nasu R, Hayashi T, Nasu-Nishimura Y, Akiyama T, Yamanaka R.

Biochem Biophys Res Commun. 2015 Apr 10;459(3):411-5. doi: 10.1016/j.bbrc.2015.02.118. Epub 2015 Feb 28.

PMID:
25735981
14.

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

González-Sancho JM, Brennan KR, Castelo-Soccio LA, Brown AM.

Mol Cell Biol. 2004 Jun;24(11):4757-68.

15.

WNT/β-catenin pathway is modulated in asthma patients and LPS-stimulated RAW264.7 macrophage cell line.

Lee H, Bae S, Choi BW, Yoon Y.

Immunopharmacol Immunotoxicol. 2012 Feb;34(1):56-65. doi: 10.3109/08923973.2011.574704. Epub 2011 Jun 24.

PMID:
21699440
16.

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling.

Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R, Li L.

Mol Cell Biol. 2013 Oct;33(20):4095-105. doi: 10.1128/MCB.00418-13. Epub 2013 Aug 19.

17.

A p120-catenin-CK1epsilon complex regulates Wnt signaling.

Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, Solanas G, Batlle E, Reynolds AB, Casal JI, de Herreros AG, Duñach M.

J Cell Sci. 2010 Aug 1;123(Pt 15):2621-31. doi: 10.1242/jcs.067512.

18.

Casein kinase Iepsilon modulates the signaling specificities of dishevelled.

Cong F, Schweizer L, Varmus H.

Mol Cell Biol. 2004 Mar;24(5):2000-11.

19.

Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.

Koraishy FM, Silva C, Mason S, Wu D, Cantley LG.

J Biol Chem. 2014 May 16;289(20):14341-50. doi: 10.1074/jbc.M114.563213. Epub 2014 Apr 1.

20.

Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.

MacDonald BT, He X.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a007880. doi: 10.1101/cshperspect.a007880. Review.

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