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Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

Hsu A, Wong CP, Yu Z, Williams DE, Dashwood RH, Ho E.

Clin Epigenetics. 2011;3:3. doi: 10.1186/1868-7083-3-3. Epub 2011 Oct 26.


Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E.

PLoS One. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014.


Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

Clarke JD, Hsu A, Yu Z, Dashwood RH, Ho E.

Mol Nutr Food Res. 2011 Jul;55(7):999-1009. doi: 10.1002/mnfr.201000547. Epub 2011 Mar 4.


Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.

Meeran SM, Patel SN, Tollefsbol TO.

PLoS One. 2010 Jul 6;5(7):e11457. doi: 10.1371/journal.pone.0011457.


Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.

Zhang C, Su ZY, Khor TO, Shu L, Kong AN.

Biochem Pharmacol. 2013 May 1;85(9):1398-404. doi: 10.1016/j.bcp.2013.02.010. Epub 2013 Feb 14.


Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.

Abbas A, Hall JA, Patterson WL 3rd, Ho E, Hsu A, Al-Mulla F, Georgel PT.

Biochem Cell Biol. 2016 Feb;94(1):71-81. doi: 10.1139/bcb-2015-0038. Epub 2015 Sep 9.


Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.

Chew YC, Adhikary G, Wilson GM, Xu W, Eckert RL.

J Biol Chem. 2012 May 11;287(20):16168-78. doi: 10.1074/jbc.M111.305292. Epub 2012 Mar 15.


Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.

Su ZY, Zhang C, Lee JH, Shu L, Wu TY, Khor TO, Conney AH, Lu YP, Kong AN.

Cancer Prev Res (Phila). 2014 Mar;7(3):319-29. doi: 10.1158/1940-6207.CAPR-13-0313-T. Epub 2014 Jan 17.


Dietary histone deacetylase inhibitors: from cells to mice to man.

Dashwood RH, Ho E.

Semin Cancer Biol. 2007 Oct;17(5):363-9. Epub 2007 May 5. Review.


Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells.

Boyanapalli SS, Li W, Fuentes F, Guo Y, Ramirez CN, Gonzalez XP, Pung D, Kong AN.

Pharmacol Res. 2016 Dec;114:175-184. doi: 10.1016/j.phrs.2016.10.021. Epub 2016 Nov 3.


Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.

Wang L, Liu D, Ahmed T, Chung FL, Conaway C, Chiao JW.

Int J Oncol. 2004 Jan;24(1):187-92.


Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.

Lubecka-Pietruszewska K, Kaufman-Szymczyk A, Stefanska B, Cebula-Obrzut B, Smolewski P, Fabianowska-Majewska K.

J Nutrigenet Nutrigenomics. 2015;8(2):91-101.


Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.

Herman-Antosiewicz A, Xiao H, Lew KL, Singh SV.

Mol Cancer Ther. 2007 May;6(5):1673-81.


Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

Beaver LM, Buchanan A, Sokolowski EI, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E.

Mol Nutr Food Res. 2014 Oct;58(10):2001-13. doi: 10.1002/mnfr.201400269. Epub 2014 Aug 5.


Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells.

Chiao JW, Chung FL, Kancherla R, Ahmed T, Mittelman A, Conaway CC.

Int J Oncol. 2002 Mar;20(3):631-6.


Hypermethylation of Cyclin D2 is associated with loss of mRNA expression and tumor development in prostate cancer.

Henrique R, Costa VL, Cerveira N, Carvalho AL, Hoque MO, Ribeiro FR, Oliveira J, Teixeira MR, Sidransky D, Jerónimo C.

J Mol Med (Berl). 2006 Nov;84(11):911-8. Epub 2006 Sep 22.


De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc.

Wang LG, Liu XM, Fang Y, Dai W, Chiao FB, Puccio GM, Feng J, Liu D, Chiao JW.

Int J Oncol. 2008 Aug;33(2):375-80.


Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.

Myzak MC, Hardin K, Wang R, Dashwood RH, Ho E.

Carcinogenesis. 2006 Apr;27(4):811-9. Epub 2005 Nov 9.


Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells.

Xiang N, Zhao R, Song G, Zhong W.

Carcinogenesis. 2008 Nov;29(11):2175-81. doi: 10.1093/carcin/bgn179. Epub 2008 Aug 1.

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