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Items: 1 to 20 of 137

1.

Determining the mode of action of bioactive compounds.

Azad MA, Wright GD.

Bioorg Med Chem. 2012 Mar 15;20(6):1929-39. doi: 10.1016/j.bmc.2011.10.088. Epub 2012 Jan 17. Review.

PMID:
22300885
2.

Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound.

Sakamoto S, Hatakeyama M, Ito T, Handa H.

Bioorg Med Chem. 2012 Mar 15;20(6):1990-2001. doi: 10.1016/j.bmc.2011.12.022. Epub 2011 Dec 21.

PMID:
22264760
3.

Target identification of small molecules based on chemical biology approaches.

Futamura Y, Muroi M, Osada H.

Mol Biosyst. 2013 May;9(5):897-914. doi: 10.1039/c2mb25468a. Review.

PMID:
23354001
4.

Identifying the cellular targets of bioactive small molecules with activity-based probes.

Li X, Hu Y.

Curr Med Chem. 2010;17(27):3030-44. Review.

PMID:
20629628
5.

Target identification of bioactive compounds.

Tashiro E, Imoto M.

Bioorg Med Chem. 2012 Mar 15;20(6):1910-21. doi: 10.1016/j.bmc.2011.10.081. Epub 2011 Nov 4. Review.

PMID:
22104438
6.

Identification and validation of bioactive small molecule target through phenotypic screening.

Cho YS, Kwon HJ.

Bioorg Med Chem. 2012 Mar 15;20(6):1922-8. doi: 10.1016/j.bmc.2011.11.021. Epub 2011 Nov 20.

PMID:
22153994
7.

Searching for the protein targets of bioactive molecules.

Chidley C, Haruki H, Pedersen MG, Fellay C, Moser S, Johnsson K.

Chimia (Aarau). 2011;65(9):720-4. Review.

PMID:
22026187
8.

Chemical-genomic profiling: systematic analysis of the cellular targets of bioactive molecules.

Andrusiak K, Piotrowski JS, Boone C.

Bioorg Med Chem. 2012 Mar 15;20(6):1952-60. doi: 10.1016/j.bmc.2011.12.023. Epub 2011 Dec 21. Review.

PMID:
22261022
9.

Morphobase, an encyclopedic cell morphology database, and its use for drug target identification.

Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H.

Chem Biol. 2012 Dec 21;19(12):1620-30. doi: 10.1016/j.chembiol.2012.10.014.

10.

Chemistry-based functional proteomics for drug target deconvolution.

Wang K, Yang T, Wu Q, Zhao X, Nice EC, Huang C.

Expert Rev Proteomics. 2012 Jun;9(3):293-310. doi: 10.1586/epr.12.19. Review.

PMID:
22809208
11.

Chemoproteomic approaches to drug target identification and drug profiling.

Bantscheff M, Drewes G.

Bioorg Med Chem. 2012 Mar 15;20(6):1973-8. doi: 10.1016/j.bmc.2011.11.003. Epub 2011 Nov 9. Review.

PMID:
22130419
12.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
13.

Strategies and future trends to identify the mode of action of phytotoxic compounds.

Tresch S.

Plant Sci. 2013 Nov;212:60-71. doi: 10.1016/j.plantsci.2013.08.005. Epub 2013 Aug 29. Review.

PMID:
24094055
14.

The end game of chemical genetics: target identification.

Kasper AC, Baker JB, Kim H, Hong J.

Future Med Chem. 2009 Jul;1(4):727-36. doi: 10.4155/fmc.09.52. Review.

PMID:
21426035
15.

How to discover new antibiotics: harvesting the parvome.

Davies J.

Curr Opin Chem Biol. 2011 Feb;15(1):5-10. doi: 10.1016/j.cbpa.2010.11.001. Epub 2010 Nov 24. Review.

PMID:
21111668
16.

A screening pattern recognition method finds new and divergent targets for drugs and natural products.

Wassermann AM, Lounkine E, Urban L, Whitebread S, Chen S, Hughes K, Guo H, Kutlina E, Fekete A, Klumpp M, Glick M.

ACS Chem Biol. 2014 Jul 18;9(7):1622-31. doi: 10.1021/cb5001839. Epub 2014 Jun 2.

PMID:
24802392
17.

Target-based drug discovery: the emerging success of frontal affinity chromatography coupled to mass spectrometry.

Calleri E, Temporini C, Caccialanza G, Massolini G.

ChemMedChem. 2009 Jun;4(6):905-16. doi: 10.1002/cmdc.200800436. Review.

PMID:
19378293
18.

A natural products approach to drug discovery: probing modes of action of antitumor agents by genome-scale cDNA library screening.

Luesch H, Abreu P.

Methods Mol Biol. 2009;572:261-77. doi: 10.1007/978-1-60761-244-5_17.

PMID:
20694698
19.

[The application of small molecule bioactive probes in the identification of cellular targets].

Zhang J, Zhou HC.

Yao Xue Xue Bao. 2012 Mar;47(3):299-306. Review. Chinese.

PMID:
22645752
20.

Recent advances in chemical genomics.

Darvas F, Dormán G, Krajcsi P, Puskás LG, Kovári Z, Lörincz Z, Urge L.

Curr Med Chem. 2004 Dec;11(23):3119-45. Review.

PMID:
15579004

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