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Drosophila cyclin D/Cdk4 regulates mitochondrial biogenesis and aging and sensitizes animals to hypoxic stress.

Icreverzi A, de la Cruz AF, Van Voorhies WA, Edgar BA.

Cell Cycle. 2012 Feb 1;11(3):554-68. doi: 10.4161/cc.11.3.19062.


Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress.

Icreverzi A, de la Cruz AF, Walker DW, Edgar BA.

Aging Cell. 2015 Oct;14(5):896-906. doi: 10.1111/acel.12376.


The Drosophila cyclin D-Cdk4 complex promotes cellular growth.

Datar SA, Jacobs HW, de la Cruz AF, Lehner CF, Edgar BA.

EMBO J. 2000 Sep 1;19(17):4543-54.


Cyclin D/Cdk4: new insights from Drosophila.

Frei C.

Cell Cycle. 2004 May;3(5):558-60.


Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.

Baltzer C, Tiefenböck SK, Marti M, Frei C.

PLoS One. 2009 Sep 9;4(9):e6935. doi: 10.1371/journal.pone.0006935.


Cyclin D does not provide essential Cdk4-independent functions in Drosophila.

Emmerich J, Meyer CA, de la Cruz AF, Edgar BA, Lehner CF.

Genetics. 2004 Oct;168(2):867-75.


Mammalian cyclin D1/Cdk4 complexes induce cell growth in Drosophila.

Datar SA, Galloni M, de la Cruz A, Marti M, Edgar BA, Frei C.

Cell Cycle. 2006 Mar;5(6):647-52.


Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.

Brookes S, Gagrica S, Sanij E, Rowe J, Gregory FJ, Hara E, Peters G.

Cell Cycle. 2015;14(8):1164-73. doi: 10.1080/15384101.2015.1010866.


Cyclin-dependent kinase 4-mediated phosphorylation inhibits Smad3 activity in cyclin D-overexpressing breast cancer cells.

Zelivianski S, Cooley A, Kall R, Jeruss JS.

Mol Cancer Res. 2010 Oct;8(10):1375-87. doi: 10.1158/1541-7786.MCR-09-0537.


Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM).

Matsushima Y, Goto Y, Kaguni LS.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18410-5. doi: 10.1073/pnas.1008924107.


CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage.

Gogolin S, Ehemann V, Becker G, Brueckner LM, Dreidax D, Bannert S, Nolte I, Savelyeva L, Bell E, Westermann F.

Cell Cycle. 2013 Apr 1;12(7):1091-104. doi: 10.4161/cc.24091.


CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection.

Jin C, Qin L, Shi Y, Candas D, Fan M, Lu CL, Vaughan AT, Shen R, Wu LS, Liu R, Li RF, Murley JS, Woloschak G, Grdina DJ, Li JJ.

Free Radic Biol Med. 2015 Apr;81:77-87. doi: 10.1016/j.freeradbiomed.2014.12.026.


Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression.

Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF.

EMBO J. 2000 Sep 1;19(17):4533-42.


Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos.

Meyer CA, Jacobs HW, Lehner CF.

Curr Biol. 2002 Apr 16;12(8):661-6.


Incomplete folding upon binding mediates Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.

Ou L, Ferreira AM, Otieno S, Xiao L, Bashford D, Kriwacki RW.

J Biol Chem. 2011 Aug 26;286(34):30142-51. doi: 10.1074/jbc.M111.244095.


Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.

Korzelius J, The I, Ruijtenberg S, Prinsen MB, Portegijs V, Middelkoop TC, Groot Koerkamp MJ, Holstege FC, Boxem M, van den Heuvel S.

PLoS Genet. 2011 Nov;7(11):e1002362. doi: 10.1371/journal.pgen.1002362.


Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.

Ghose P, Park EC, Tabakin A, Salazar-Vasquez N, Rongo C.

PLoS Genet. 2013;9(12):e1004063. doi: 10.1371/journal.pgen.1004063.


Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: Effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression.

Grillo M, Bott MJ, Khandke N, McGinnis JP, Miranda M, Meyyappan M, Rosfjord EC, Rabindran SK.

Breast Cancer Res Treat. 2006 Jan;95(2):185-94.

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