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The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover.

Wen X, Casey Klockow L, Nekorchuk M, Sharifi HJ, de Noronha CM.

PLoS One. 2012;7(1):e30939. doi: 10.1371/journal.pone.0030939. Epub 2012 Jan 24.


HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.

Ahn J, Vu T, Novince Z, Guerrero-Santoro J, Rapic-Otrin V, Gronenborn AM.

J Biol Chem. 2010 Nov 26;285(48):37333-41. doi: 10.1074/jbc.M110.133181. Epub 2010 Sep 24.


Inhibition of Vpx-Mediated SAMHD1 and Vpr-Mediated Host Helicase Transcription Factor Degradation by Selective Disruption of Viral CRL4 (DCAF1) E3 Ubiquitin Ligase Assembly.

Wang H, Guo H, Su J, Rui Y, Zheng W, Gao W, Zhang W, Li Z, Liu G, Markham RB, Wei W, Yu XF.

J Virol. 2017 Apr 13;91(9). pii: e00225-17. doi: 10.1128/JVI.00225-17. Print 2017 May 1.


The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction.

Wu Y, Zhou X, Barnes CO, DeLucia M, Cohen AE, Gronenborn AM, Ahn J, Calero G.

Nat Struct Mol Biol. 2016 Oct;23(10):933-940. doi: 10.1038/nsmb.3284. Epub 2016 Aug 29.


Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest.

Hakata Y, Miyazawa M, Landau NR.

Virol J. 2014 Jun 9;11:108. doi: 10.1186/1743-422X-11-108.


Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.

Sharifi HJ, Furuya AK, Jellinger RM, Nekorchuk MD, de Noronha CM.

J Virol. 2014 Jun;88(12):6944-58. doi: 10.1128/JVI.00241-14. Epub 2014 Apr 9.


The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection.

Casey Klockow L, Sharifi HJ, Wen X, Flagg M, Furuya AK, Nekorchuk M, de Noronha CM.

Virology. 2013 Sep;444(1-2):191-202. doi: 10.1016/j.virol.2013.06.010. Epub 2013 Jul 9.


Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.

Gérard FC, Yang R, Romani B, Poisson A, Belzile JP, Rougeau N, Cohen ÉA.

PLoS One. 2014 Feb 18;9(2):e89195. doi: 10.1371/journal.pone.0089195. eCollection 2014.


HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins.

Hrecka K, Hao C, Shun MC, Kaur S, Swanson SK, Florens L, Washburn MP, Skowronski J.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3921-30. doi: 10.1073/pnas.1605023113. Epub 2016 Jun 22.


Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.

Le Rouzic E, Morel M, Ayinde D, Belaïdouni N, Letienne J, Transy C, Margottin-Goguet F.

J Biol Chem. 2008 Aug 1;283(31):21686-92. doi: 10.1074/jbc.M710298200. Epub 2008 Jun 4.


A novel DCAF1-binding motif required for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

Wei W, Guo H, Han X, Liu X, Zhou X, Zhang W, Yu XF.

Cell Microbiol. 2012 Nov;14(11):1745-56. doi: 10.1111/j.1462-5822.2012.01835.x. Epub 2012 Aug 9.


HIV-1 Vpr suppresses the cytomegalovirus promoter in a CRL4(DCAF1) E3 ligase independent manner.

Liu X, Guo H, Wang H, Markham R, Wei W, Yu XF.

Biochem Biophys Res Commun. 2015 Apr 3;459(2):214-9. doi: 10.1016/j.bbrc.2015.02.060. Epub 2015 Feb 19.


HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.

Romani B, Shaykh Baygloo N, Aghasadeghi MR, Allahbakhshi E.

J Biol Chem. 2015 Jul 10;290(28):17380-9. doi: 10.1074/jbc.M115.641522. Epub 2015 Jun 1.


HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.

Maudet C, Sourisce A, Dragin L, Lahouassa H, Rain JC, Bouaziz S, Ramirez BC, Margottin-Goguet F.

PLoS One. 2013 Oct 8;8(10):e77320. doi: 10.1371/journal.pone.0077320. eCollection 2013.


HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.

Zhou X, DeLucia M, Hao C, Hrecka K, Monnie C, Skowronski J, Ahn J.

J Biol Chem. 2017 Dec 22;292(51):21117-21127. doi: 10.1074/jbc.M117.798801. Epub 2017 Oct 27.


HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.

Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F.

Cell Cycle. 2007 Jan 15;6(2):182-8. Epub 2007 Jan 17.


Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.

Eldin P, Chazal N, Fenard D, Bernard E, Guichou JF, Briant L.

Nucleic Acids Res. 2014 Feb;42(3):1698-710. doi: 10.1093/nar/gkt974. Epub 2013 Oct 30.


Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.

Maudet C, Bertrand M, Le Rouzic E, Lahouassa H, Ayinde D, Nisole S, Goujon C, Cimarelli A, Margottin-Goguet F, Transy C.

J Biol Chem. 2011 Jul 8;286(27):23742-52. doi: 10.1074/jbc.M111.220780. Epub 2011 May 12.


Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx.

Cassiday PA, DePaula-Silva AB, Chumley J, Ward J, Barker E, Planelles V.

Virology. 2015 Feb;476:19-25. doi: 10.1016/j.virol.2014.11.024. Epub 2014 Dec 11.

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