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Items: 1 to 20 of 335


Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.

Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh RF, Hebrok M, Ramalho-Santos M.

Hum Mol Genet. 2012 May 1;21(9):2054-67. doi: 10.1093/hmg/dds023. Epub 2012 Jan 27.


The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.

Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, Krupalnik V, Zerbib M, Amann-Zalcenstein D, Maza I, Geula S, Viukov S, Holtzman L, Pribluda A, Canaani E, Horn-Saban S, Amit I, Novershtern N, Hanna JH.

Nature. 2012 Aug 16;488(7411):409-13. doi: 10.1038/nature11272.


Lats2 is critical for the pluripotency and proper differentiation of stem cells.

Aylon Y, Sarver A, Tovy A, Ainbinder E, Oren M.

Cell Death Differ. 2014 Apr;21(4):624-33. doi: 10.1038/cdd.2013.188. Epub 2014 Jan 10.


YAP Induces Human Naive Pluripotency.

Qin H, Hejna M, Liu Y, Percharde M, Wossidlo M, Blouin L, Durruthy-Durruthy J, Wong P, Qi Z, Yu J, Qi LS, Sebastiano V, Song JS, Ramalho-Santos M.

Cell Rep. 2016 Mar 15;14(10):2301-12. doi: 10.1016/j.celrep.2016.02.036. Epub 2016 Mar 3.


The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.

Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL.

Genes Dev. 2010 Jun 1;24(11):1106-18. doi: 10.1101/gad.1903310.


Pluripotent stem cells derived from mouse primordial germ cells by small molecule compounds.

Kimura T, Kaga Y, Sekita Y, Fujikawa K, Nakatani T, Odamoto M, Funaki S, Ikawa M, Abe K, Nakano T.

Stem Cells. 2015 Jan;33(1):45-55. doi: 10.1002/stem.1838.


Epithelial cell adhesion molecule (EpCAM) complex proteins promote transcription factor-mediated pluripotency reprogramming.

Huang HP, Chen PH, Yu CY, Chuang CY, Stone L, Hsiao WC, Li CL, Tsai SC, Chen KY, Chen HF, Ho HN, Kuo HC.

J Biol Chem. 2011 Sep 23;286(38):33520-32. doi: 10.1074/jbc.M111.256164. Epub 2011 Jul 28.


Conversion of partially reprogrammed cells to fully pluripotent stem cells is associated with further activation of stem cell maintenance- and gamete generation-related genes.

Kim JS, Choi HW, Choi S, Seo HG, Moon SH, Chung HM, Do JT.

Stem Cells Dev. 2014 Nov 1;23(21):2637-48. doi: 10.1089/scd.2014.0020. Epub 2014 Aug 20.


Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming.

Sakurai K, Talukdar I, Patil VS, Dang J, Li Z, Chang KY, Lu CC, Delorme-Walker V, Dermardirossian C, Anderson K, Hanein D, Yang CS, Wu D, Liu Y, Rana TM.

Cell Stem Cell. 2014 Apr 3;14(4):523-34. doi: 10.1016/j.stem.2014.03.001.


Epigenetic Aberrations Are Not Specific to Transcription Factor-Mediated Reprogramming.

Tiemann U, Wu G, Marthaler AG, Schöler HR, Tapia N.

Stem Cell Reports. 2016 Jan 12;6(1):35-43. doi: 10.1016/j.stemcr.2015.11.007. Epub 2015 Dec 17.


A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL.

Genes Dev. 2015 Jun 15;29(12):1271-84. doi: 10.1101/gad.262816.115.


Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies.

Goyal A, Chavez SL, Reijo Pera RA.

PLoS One. 2013 Dec 12;8(12):e82838. doi: 10.1371/journal.pone.0082838. eCollection 2013.


Tumor suppressor LATS1 is a negative regulator of oncogene YAP.

Hao Y, Chun A, Cheung K, Rashidi B, Yang X.

J Biol Chem. 2008 Feb 29;283(9):5496-509. Epub 2007 Dec 24.


Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

Lange AW, Sridharan A, Xu Y, Stripp BR, Perl AK, Whitsett JA.

J Mol Cell Biol. 2015 Feb;7(1):35-47. doi: 10.1093/jmcb/mju046. Epub 2014 Dec 5.


Linking incomplete reprogramming to the improved pluripotency of murine embryonal carcinoma cell-derived pluripotent stem cells.

Chang G, Miao YL, Zhang Y, Liu S, Kou Z, Ding J, Chen DY, Sun QY, Gao S.

PLoS One. 2010 Apr 26;5(4):e10320. doi: 10.1371/journal.pone.0010320.


Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.

Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y.

Cancer Res. 2011 Mar 15;71(6):2162-71. doi: 10.1158/0008-5472.CAN-10-3268. Epub 2011 Jan 28.


Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA.

EMBO Rep. 2013 Jul;14(7):629-37. doi: 10.1038/embor.2013.67. Epub 2013 May 14.


Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.

Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y.

Cancer Lett. 2017 Jan 28;385:215-224. doi: 10.1016/j.canlet.2016.10.020. Epub 2016 Oct 20.


Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

Hayashi K, Ohta H, Kurimoto K, Aramaki S, Saitou M.

Cell. 2011 Aug 19;146(4):519-32. doi: 10.1016/j.cell.2011.06.052. Epub 2011 Aug 4.

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