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Items: 1 to 20 of 153

1.

Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity.

De Bock L, Boussery K, Colin P, De Smet J, T'jollyn H, Van Bocxlaer J.

Talanta. 2012 Jan 30;89:209-16. doi: 10.1016/j.talanta.2011.11.083. Epub 2011 Dec 9.

PMID:
22284482
2.

A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates.

Liu LY, Han YL, Zhu JH, Yu Q, Yang QJ, Lu J, Guo C.

Biomed Chromatogr. 2015 Mar;29(3):437-44. doi: 10.1002/bmc.3294. Epub 2014 Aug 6.

PMID:
25098274
3.

Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.

Zhang S, Song N, Li Q, Fan H, Liu C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 1;871(1):78-89. doi: 10.1016/j.jchromb.2008.06.034. Epub 2008 Jun 27.

PMID:
18614408
4.
5.

Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats.

Ma J, Wang S, Zhang M, Zhang Q, Zhou Y, Lin C, Lin G, Wang X.

Biomed Chromatogr. 2015 Aug;29(8):1203-12. doi: 10.1002/bmc.3409. Epub 2015 Jan 13.

PMID:
25582505
6.

Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases.

Lee JT, Pao LH, Hsiong CH, Huang PW, Shih TY, Yoa-Pu Hu O.

Talanta. 2013 Mar 15;106:220-8. doi: 10.1016/j.talanta.2012.12.023. Epub 2012 Dec 22.

PMID:
23598120
7.

An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.

Youdim KA, Lyons R, Payne L, Jones BC, Saunders K.

J Pharm Biomed Anal. 2008 Sep 10;48(1):92-9. doi: 10.1016/j.jpba.2008.05.011. Epub 2008 May 17.

PMID:
18584988
9.

Absolute protein quantification of clinically relevant cytochrome P450 enzymes and UDP-glucuronosyltransferases by mass spectrometry-based targeted proteomics.

Gröer C, Busch D, Patrzyk M, Beyer K, Busemann A, Heidecke CD, Drozdzik M, Siegmund W, Oswald S.

J Pharm Biomed Anal. 2014 Nov;100:393-401. doi: 10.1016/j.jpba.2014.08.016. Epub 2014 Aug 17.

PMID:
25218440
10.

A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.

Stewart NA, Buch SC, Conrads TP, Branch RA.

Analyst. 2011 Feb 7;136(3):605-12. doi: 10.1039/c0an00643b. Epub 2010 Nov 25.

11.

Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.

Yao M, Zhu M, Sinz MW, Zhang H, Humphreys WG, Rodrigues AD, Dai R.

J Pharm Biomed Anal. 2007 May 9;44(1):211-23. Epub 2007 Mar 3.

PMID:
17418993
12.

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

Wen X, Wang JS, Backman JT, Kivistö KT, Neuvonen PJ.

Drug Metab Dispos. 2001 Nov;29(11):1359-61.

14.

Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A.

von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI.

J Pharm Pharmacol. 1998 Sep;50(9):997-1004.

PMID:
9811160
15.

An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay.

Bansal S, Chai SF, Lau AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 15;1023-1024:1-8. doi: 10.1016/j.jchromb.2016.04.039. Epub 2016 Apr 27.

PMID:
27153105
16.

In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.

Zhao K, Ding M, Cao H, Cao ZX.

J Pharm Pharmacol. 2012 Oct;64(10):1445-51. doi: 10.1111/j.2042-7158.2012.01516.x. Epub 2012 May 2.

PMID:
22943175
17.

Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro.

He M, Jiang J, Qiu F, Liu S, Peng P, Gao C, Miao P.

Food Chem Toxicol. 2013 Jul;57:262-5. doi: 10.1016/j.fct.2013.03.041. Epub 2013 Apr 9.

PMID:
23583485
18.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
19.

Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

Lim HK, Duczak N Jr, Brougham L, Elliot M, Patel K, Chan K.

Drug Metab Dispos. 2005 Aug;33(8):1211-9. Epub 2005 Apr 28.

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