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Items: 1 to 20 of 159

1.

Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.

Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H.

J Immunol. 2012 Mar 1;188(5):2427-36. doi: 10.4049/jimmunol.1101128. Epub 2012 Jan 25.

2.

Epithelial NEMO links innate immunity to chronic intestinal inflammation.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M.

Nature. 2007 Mar 29;446(7135):557-61. Epub 2007 Mar 14.

3.

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.

Steinbrecher KA, Harmel-Laws E, Sitcheran R, Baldwin AS.

J Immunol. 2008 Feb 15;180(4):2588-99.

5.

Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis.

Allaire JM, Darsigny M, Marcoux SS, Roy SA, Schmouth JF, Umans L, Zwijsen A, Boudreau F, Perreault N.

Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G586-97. doi: 10.1152/ajpgi.00041.2010. Epub 2011 Jan 6.

6.

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.

Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H.

Gastroenterology. 2011 Aug;141(2):621-32. doi: 10.1053/j.gastro.2011.04.056. Epub 2011 May 5.

PMID:
21669204
7.

Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.

Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K.

Cell Metab. 2006 Jan;3(1):59-65.

8.

The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis.

Turgeon N, Gagné JM, Blais M, Gendron FP, Boudreau F, Asselin C.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 1;306(7):G594-605. doi: 10.1152/ajpgi.00393.2013. Epub 2014 Feb 13.

9.

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides.

Frantz AL, Rogier EW, Weber CR, Shen L, Cohen DA, Fenton LA, Bruno ME, Kaetzel CS.

Mucosal Immunol. 2012 Sep;5(5):501-12. doi: 10.1038/mi.2012.23. Epub 2012 Apr 11.

10.

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.

Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T, Honjo T.

Nat Immunol. 2002 May;3(5):443-50. Epub 2002 Apr 22.

PMID:
11967543
11.

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing.

Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C.

J Exp Med. 2009 Jul 6;206(7):1465-72. doi: 10.1084/jem.20082683. Epub 2009 Jun 29.

12.

Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression.

Kim TH, Shivdasani RA.

J Biol Chem. 2011 Apr 1;286(13):11427-33. doi: 10.1074/jbc.M110.188797. Epub 2011 Jan 31.

13.

CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.

Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, Iwakura Y, Yoshikai Y.

J Immunol. 2010 Dec 15;185(12):7671-80. doi: 10.4049/jimmunol.1002229. Epub 2010 Nov 10.

14.

The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.

Xiao H, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Wald D, Ma C, Zhou H, Tuohy VK, Fairchild RL, de la Motte C, Cua D, Vallance BA, Li X.

Immunity. 2007 Apr;26(4):461-75. Epub 2007 Mar 29.

15.

Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.

Han H, Tanigaki K, Yamamoto N, Kuroda K, Yoshimoto M, Nakahata T, Ikuta K, Honjo T.

Int Immunol. 2002 Jun;14(6):637-45.

PMID:
12039915
16.

The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.

Hapfelmeier S, Stecher B, Barthel M, Kremer M, Müller AJ, Heikenwalder M, Stallmach T, Hensel M, Pfeffer K, Akira S, Hardt WD.

J Immunol. 2005 Feb 1;174(3):1675-85.

17.

Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis.

Cao AT, Yao S, Gong B, Elson CO, Cong Y.

J Immunol. 2012 Nov 1;189(9):4666-73. doi: 10.4049/jimmunol.1200955. Epub 2012 Sep 19.

18.

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.

Buono KD, Robinson GW, Martin C, Shi S, Stanley P, Tanigaki K, Honjo T, Hennighausen L.

Dev Biol. 2006 May 15;293(2):565-80. Epub 2006 Apr 11.

19.

Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types.

Hu XB, Feng F, Wang YC, Wang L, He F, Dou GR, Liang L, Zhang HW, Liang YM, Han H.

Neoplasia. 2009 Jan;11(1):32-8.

20.

RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice.

Schouwey K, Aydin IT, Radtke F, Beermann F.

Oncogene. 2011 Jan 20;30(3):313-22. doi: 10.1038/onc.2010.428. Epub 2010 Sep 20.

PMID:
20856205

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