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P53-induced protein with a death domain (PIDD): master of puppets?

Bock FJ, Peintner L, Tanzer M, Manzl C, Villunger A.

Oncogene. 2012 Nov 8;31(45):4733-9. doi: 10.1038/onc.2011.639. Epub 2012 Jan 23. Review.


PIDDosome-independent tumor suppression by Caspase-2.

Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A.

Cell Death Differ. 2012 Oct;19(10):1722-32. doi: 10.1038/cdd.2012.54. Epub 2012 May 18.


The PIDDosome, DNA-damage-induced apoptosis and beyond.

Janssens S, Tinel A.

Cell Death Differ. 2012 Jan;19(1):13-20. doi: 10.1038/cdd.2011.162. Epub 2011 Nov 18. Review.


Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.

Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A.

Cell Death Differ. 2013 Apr;20(4):546-57. doi: 10.1038/cdd.2012.152. Epub 2012 Dec 14.


p53-induced protein with a death domain (PIDD) isoforms differentially activate nuclear factor-kappaB and caspase-2 in response to genotoxic stress.

Cuenin S, Tinel A, Janssens S, Tschopp J.

Oncogene. 2008 Jan 10;27(3):387-96. Epub 2007 Jul 16.


Involvement of upregulated p53-induced death domain protein (PIDD) in neuronal apoptosis after rat traumatic brain injury.

Wan C, Jiang J, Mao H, Cao J, Wu X, Cui G.

J Mol Neurosci. 2013 Nov;51(3):695-702.


PIDD mediates NF-kappaB activation in response to DNA damage.

Janssens S, Tinel A, Lippens S, Tschopp J.

Cell. 2005 Dec 16;123(6):1079-92.


Caspase-2: the orphan caspase.

Bouchier-Hayes L, Green DR.

Cell Death Differ. 2012 Jan;19(1):51-7. doi: 10.1038/cdd.2011.157. Epub 2011 Nov 11. Review.


DNA damage- and stress-induced apoptosis occurs independently of PIDD.

Kim IR, Murakami K, Chen NJ, Saibil SD, Matysiak-Zablocki E, Elford AR, Bonnard M, Benchimol S, Jurisicova A, Yeh WC, Ohashi PS.

Apoptosis. 2009 Sep;14(9):1039-49. doi: 10.1007/s10495-009-0375-1.


Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.

Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A.

Cell Death Dis. 2013 Dec 5;4:e942. doi: 10.1038/cddis.2013.470.


Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.

Tinel A, Janssens S, Lippens S, Cuenin S, Logette E, Jaccard B, Quadroni M, Tschopp J.

EMBO J. 2007 Jan 10;26(1):197-208. Epub 2006 Dec 7.


PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.

Ando K, Kernan JL, Liu PH, Sanda T, Logette E, Tschopp J, Look AT, Wang J, Bouchier-Hayes L, Sidi S.

Mol Cell. 2012 Sep 14;47(5):681-93. doi: 10.1016/j.molcel.2012.06.024. Epub 2012 Jul 30.


Caspase-2 activation in the absence of PIDDosome formation.

Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A.

J Cell Biol. 2009 Apr 20;185(2):291-303. doi: 10.1083/jcb.200811105. Epub 2009 Apr 13.


Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.

Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T.

Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012.


Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS.

J Neurosci. 2004 Mar 24;24(12):2963-73.


PIDD orchestrates translesion DNA synthesis in response to UV irradiation.

Logette E, Schuepbach-Mallepell S, Eckert MJ, Leo XH, Jaccard B, Manzl C, Tardivel A, Villunger A, Quadroni M, Gaide O, Tschopp J.

Cell Death Differ. 2011 Jun;18(6):1036-45. doi: 10.1038/cdd.2011.19. Epub 2011 Mar 18.


MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.

Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS.

J Biol Chem. 2009 May 15;284(20):13533-41. doi: 10.1074/jbc.M808554200. Epub 2009 Mar 16.


The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma.

Lin J, Yang Q, Wilder PT, Carrier F, Weber DJ.

J Biol Chem. 2010 Aug 27;285(35):27487-98. doi: 10.1074/jbc.M110.155382. Epub 2010 Jun 29.


Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.

Ribe EM, Jean YY, Goldstein RL, Manzl C, Stefanis L, Villunger A, Troy CM.

Biochem J. 2012 Jun 15;444(3):591-9. doi: 10.1042/BJ20111588.

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