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Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity.

Strasser D, Neumann K, Bergmann H, Marakalala MJ, Guler R, Rojowska A, Hopfner KP, Brombacher F, Urlaub H, Baier G, Brown GD, Leitges M, Ruland J.

Immunity. 2012 Jan 27;36(1):32-42. doi: 10.1016/j.immuni.2011.11.015.


Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.

LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C.

Nat Immunol. 2007 Jun;8(6):630-8. Epub 2007 Apr 22.


CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.

Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X.

J Biol Chem. 2010 Aug 20;285(34):25969-77. doi: 10.1074/jbc.M110.131300. Epub 2010 Jun 9.


Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.

Gross O, Gewies A, Finger K, Schäfer M, Sparwasser T, Peschel C, Förster I, Ruland J.

Nature. 2006 Aug 10;442(7103):651-6. Epub 2006 Jul 12.


Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection.

Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C.

J Exp Med. 2009 Aug 31;206(9):2037-51. doi: 10.1084/jem.20082818. Epub 2009 Aug 24.


Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye.

Lee EJ, Brown BR, Vance EE, Snow PE, Silver PB, Heinrichs D, Lin X, Iwakura Y, Wells CA, Caspi RR, Rosenzweig HL.

J Immunol. 2016 Apr 1;196(7):3148-58. doi: 10.4049/jimmunol.1502355. Epub 2016 Feb 26.


Activation of NF-κB and respiratory burst following Aspergillus fumigatus stimulation of macrophages.

Sun H, Xu XY, Tian XL, Shao HT, Wu XD, Wang Q, Su X, Shi Y.

Immunobiology. 2014 Jan;219(1):25-36. doi: 10.1016/j.imbio.2013.06.013. Epub 2013 Jul 4.


The role of Syk/CARD9 coupled C-type lectins in antifungal immunity.

Drummond RA, Saijo S, Iwakura Y, Brown GD.

Eur J Immunol. 2011 Feb;41(2):276-81. doi: 10.1002/eji.201041252. Epub 2011 Jan 11. Review.


C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.

Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Luo T, Jia XM, Lin X.

J Biol Chem. 2014 Oct 24;289(43):30052-62. doi: 10.1074/jbc.M114.588574. Epub 2014 Sep 8.


C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses.

Kingeter LM, Lin X.

Cell Mol Immunol. 2012 Mar;9(2):105-12. doi: 10.1038/cmi.2011.58. Epub 2012 Jan 16. Review.


Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells.

Xu S, Huo J, Lee KG, Kurosaki T, Lam KP.

J Biol Chem. 2009 Mar 13;284(11):7038-46. doi: 10.1074/jbc.M806650200. Epub 2009 Jan 9.


Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J.

Cell Rep. 2016 Dec 6;17(10):2572-2583. doi: 10.1016/j.celrep.2016.11.018.


CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.

Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin X.

J Exp Med. 2014 Oct 20;211(11):2307-21. doi: 10.1084/jem.20132349. Epub 2014 Sep 29.


Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.

Ostrop J, Jozefowski K, Zimmermann S, Hofmann K, Strasser E, Lepenies B, Lang R.

J Immunol. 2015 Sep 1;195(5):2417-28. doi: 10.4049/jimmunol.1500102. Epub 2015 Jul 22.


Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation.

Werninghaus K, Babiak A, Gross O, Hölscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning C, Heit A, Andersen P, Wagner H, Ruland J, Lang R.

J Exp Med. 2009 Jan 16;206(1):89-97. doi: 10.1084/jem.20081445. Epub 2009 Jan 12.


Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.

del Fresno C, Soulat D, Roth S, Blazek K, Udalova I, Sancho D, Ruland J, Ardavín C.

Immunity. 2013 Jun 27;38(6):1176-86. doi: 10.1016/j.immuni.2013.05.010. Epub 2013 Jun 13.


The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.

Marakalala MJ, Graham LM, Brown GD.

Clin Dev Immunol. 2010;2010:567571. doi: 10.1155/2010/567571. Epub 2011 Jan 9. Review.


CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1.

Yang H, He H, Dong Y.

Eur J Clin Microbiol Infect Dis. 2011 Mar;30(3):303-5. doi: 10.1007/s10096-010-1103-z. Epub 2010 Nov 25. Review.


Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.

Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM.

J Immunol. 2009 Jan 15;182(2):1146-54.


The adaptor molecule CARD9 is essential for tuberculosis control.

Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH.

J Exp Med. 2010 Apr 12;207(4):777-92. doi: 10.1084/jem.20090067. Epub 2010 Mar 29.

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