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Items: 1 to 20 of 130

1.

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

Taliani S, Pugliesi I, Barresi E, Simorini F, Salerno S, La Motta C, Marini AM, Cosimelli B, Cosconati S, Di Maro S, Marinelli L, Daniele S, Trincavelli ML, Greco G, Novellino E, Martini C, Da Settimo F.

J Med Chem. 2012 Feb 23;55(4):1490-9. doi: 10.1021/jm201177b. Epub 2012 Feb 7.

PMID:
22257095
2.

Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.

Baraldi PG, Baraldi S, Saponaro G, Preti D, Romagnoli R, Piccagli L, Cavalli A, Recanatini M, Moorman AR, Zaid AN, Varani K, Borea PA, Tabrizi MA.

J Med Chem. 2012 Jan 26;55(2):797-811. doi: 10.1021/jm201292w. Epub 2012 Jan 11.

PMID:
22148859
3.

3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects.

Scatena A, Fornai F, Trincavelli ML, Taliani S, Daniele S, Pugliesi I, Cosconati S, Martini C, Da Settimo F.

ACS Chem Neurosci. 2011 Sep 21;2(9):526-35. doi: 10.1021/cn200036s. Epub 2011 Jun 10.

4.

Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.

Baraldi PG, Tabrizi MA, Preti D, Bovero A, Romagnoli R, Fruttarolo F, Zaid NA, Moorman AR, Varani K, Gessi S, Merighi S, Borea PA.

J Med Chem. 2004 Mar 11;47(6):1434-47.

PMID:
14998332
5.

Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

Petroni D, Giacomelli C, Taliani S, Barresi E, Robello M, Daniele S, Bartoli A, Burchielli S, Pardini S, Salvadori PA, Da Settimo F, Martini C, Trincavelli ML, Menichetti L.

Nucl Med Biol. 2016 May;43(5):309-17. doi: 10.1016/j.nucmedbio.2016.02.005. Epub 2016 Feb 27.

PMID:
27150034
6.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Simorini F, Salerno S, Sergianni V, Tuccinardi T, Martinelli A, Cosimelli B, Greco G, Novellino E, Ciampi O, Trincavelli ML, Martini C.

J Med Chem. 2007 Nov 15;50(23):5676-84. Epub 2007 Oct 10.

PMID:
17927167
7.

New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.

Baraldi PG, Preti D, Zaid AN, Saponaro G, Tabrizi MA, Baraldi S, Romagnoli R, Moorman AR, Varani K, Cosconati S, Di Maro S, Marinelli L, Novellino E, Borea PA.

J Med Chem. 2011 Jul 28;54(14):5205-20. doi: 10.1021/jm2004738. Epub 2011 Jun 28.

PMID:
21675777
8.

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.

Stefanachi A, Nicolotti O, Leonetti F, Cellamare S, Campagna F, Loza MI, Brea JM, Mazza F, Gavuzzo E, Carotti A.

Bioorg Med Chem. 2008 Nov 15;16(22):9780-9. doi: 10.1016/j.bmc.2008.09.067. Epub 2008 Sep 30.

PMID:
18938084
9.

Novel fluorescent triazinobenzimidazole derivatives as probes for labelling human A1 and A2B adenosine receptor subtypes.

Barresi E, Giacomelli C, Daniele S, Tonazzini I, Robello M, Salerno S, Piano I, Cosimelli B, Greco G, Da Settimo F, Martini C, Trincavelli ML, Taliani S.

Bioorg Med Chem. 2018 Dec 1;26(22):5885-5895. doi: 10.1016/j.bmc.2018.10.039. Epub 2018 Nov 1.

PMID:
30415894
10.

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.

Federico S, Paoletta S, Cheong SL, Pastorin G, Cacciari B, Stragliotto S, Klotz KN, Siegel J, Gao ZG, Jacobson KA, Moro S, Spalluto G.

J Med Chem. 2011 Feb 10;54(3):877-89. doi: 10.1021/jm101349u. Epub 2011 Jan 7.

11.

Benzothiazinones: a novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives.

Gütschow M, Schlenk M, Gäb J, Paskaleva M, Alnouri MW, Scolari S, Iqbal J, Müller CE.

J Med Chem. 2012 Apr 12;55(7):3331-41. doi: 10.1021/jm300029s. Epub 2012 Mar 27.

PMID:
22409573
12.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

Taliani S, La Motta C, Mugnaini L, Simorini F, Salerno S, Marini AM, Da Settimo F, Cosconati S, Cosimelli B, Greco G, Limongelli V, Marinelli L, Novellino E, Ciampi O, Daniele S, Trincavelli ML, Martini C.

J Med Chem. 2010 May 27;53(10):3954-63. doi: 10.1021/jm901785w.

PMID:
20408530
13.

New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.

Baraldi PG, Tabrizi MA, Preti D, Bovero A, Fruttarolo F, Romagnoli R, Zaid NA, Moorman AR, Varani K, Borea PA.

J Med Chem. 2005 Jul 28;48(15):5001-8.

PMID:
16033279
14.

Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists.

Cosimelli B, Greco G, Ehlardo M, Novellino E, Da Settimo F, Taliani S, La Motta C, Bellandi M, Tuccinardi T, Martinelli A, Ciampi O, Trincavelli ML, Martini C.

J Med Chem. 2008 Mar 27;51(6):1764-70. doi: 10.1021/jm701159t. Epub 2008 Feb 13.

PMID:
18269230
15.
16.

3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.

Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Novellino E, Greco G, Lavecchia A, Trincavelli L, Martini C.

J Med Chem. 2001 Feb 1;44(3):316-27.

PMID:
11462973
17.

Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.

Primofiore G, Da Settimo F, Taliani S, Marini AM, Simorini F, Novellino E, Greco G, Trincavelli L, Martini C.

Arch Pharm (Weinheim). 2003 Sep;336(9):413-21.

PMID:
14528489
18.

Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.

Bosch MP, Campos F, Niubó I, Rosell G, Díaz JL, Brea J, Loza MI, Guerrero A.

J Med Chem. 2004 Jul 29;47(16):4041-53.

PMID:
15267242
19.

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Kalla RV, Elzein E, Perry T, Li X, Palle V, Varkhedkar V, Gimbel A, Maa T, Zeng D, Zablocki J.

J Med Chem. 2006 Jun 15;49(12):3682-92.

PMID:
16759111
20.

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.

Lenzi O, Colotta V, Catarzi D, Varano F, Poli D, Filacchioni G, Varani K, Vincenzi F, Borea PA, Paoletta S, Morizzo E, Moro S.

J Med Chem. 2009 Dec 10;52(23):7640-52. doi: 10.1021/jm900718w.

PMID:
19743865

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