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CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.

Selvakumar D, Drescher MJ, Dowdall JR, Khan KM, Hatfield JS, Ramakrishnan NA, Drescher DG.

Biochem J. 2012 Apr 15;443(2):463-76. doi: 10.1042/BJ20111255.


Calcium-dependent binding of HCN1 channel protein to hair cell stereociliary tip link protein protocadherin 15 CD3.

Ramakrishnan NA, Drescher MJ, Barretto RL, Beisel KW, Hatfield JS, Drescher DG.

J Biol Chem. 2009 Jan 30;284(5):3227-38. doi: 10.1074/jbc.M806177200. Epub 2008 Nov 13.


HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.

Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG.

J Biol Chem. 2012 Nov 2;287(45):37628-46. doi: 10.1074/jbc.M112.375832. Epub 2012 Sep 4.


CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions.

Dai G, Varnum MD.

Am J Physiol Cell Physiol. 2013 Jul 15;305(2):C147-59. doi: 10.1152/ajpcell.00037.2013. Epub 2013 Apr 3.


Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides.

Dai G, Sherpa T, Varnum MD.

J Biol Chem. 2014 May 9;289(19):13680-90. doi: 10.1074/jbc.M114.562272. Epub 2014 Mar 27.


Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel: the primary, full-length HCN isoform expressed in a saccular hair-cell layer.

Cho WJ, Drescher MJ, Hatfield JS, Bessert DA, Skoff RP, Drescher DG.

Neuroscience. 2003;118(2):525-34.


Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction.

Drescher MJ, Barretto RL, Chaturvedi D, Beisel KW, Hatfield JS, Khan KM, Drescher DG.

Brain Res Mol Brain Res. 2002 Jan 31;98(1-2):1-14.


Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.

Dai G, Peng C, Liu C, Varnum MD.

J Gen Physiol. 2013 Apr;141(4):413-30. doi: 10.1085/jgp.201210944.


An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells.

Drescher MJ, Cho WJ, Folbe AJ, Selvakumar D, Kewson DT, Abu-Hamdan MD, Oh CK, Ramakrishnan NA, Hatfield JS, Khan KM, Anne S, Harpool EC, Drescher DG.

Neuroscience. 2010 Dec 29;171(4):1054-74. doi: 10.1016/j.neuroscience.2010.09.051. Epub 2010 Sep 29.


CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.

Rebrik TI, Botchkina I, Arshavsky VY, Craft CM, Korenbrot JI.

J Neurosci. 2012 Feb 29;32(9):3142-53. doi: 10.1523/JNEUROSCI.5518-11.2012.


Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment.

Tanaka N, Dutrow EV, Miyadera K, Delemotte L, MacDermaid CM, Reinstein SL, Crumley WR, Dixon CJ, Casal ML, Klein ML, Aguirre GD, Tanaka JC, Guziewicz KE.

PLoS One. 2015 Sep 25;10(9):e0138943. doi: 10.1371/journal.pone.0138943. eCollection 2015.


Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.

Ma H, Thapa A, Morris LM, Michalakis S, Biel M, Frank MB, Bebak M, Ding XQ.

Hum Mol Genet. 2013 Oct 1;22(19):3906-19. doi: 10.1093/hmg/ddt245. Epub 2013 Jun 4.


A cyclic nucleotide-gated channel mutation associated with canine daylight blindness provides insight into a role for the S2 segment tri-Asp motif in channel biogenesis.

Tanaka N, Delemotte L, Klein ML, Komáromy AM, Tanaka JC.

PLoS One. 2014 Feb 21;9(2):e88768. doi: 10.1371/journal.pone.0088768. eCollection 2014.


cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.

Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ.

J Neurosci. 2013 Sep 11;33(37):14939-48. doi: 10.1523/JNEUROSCI.0909-13.2013.


Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, resulting in achromatopsia.

Reuter P, Koeppen K, Ladewig T, Kohl S, Baumann B, Wissinger B; Achromatopsia Clinical Study Group.

Hum Mutat. 2008 Oct;29(10):1228-36. doi: 10.1002/humu.20790.


Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

Meighan SE, Meighan PC, Rich ED, Brown RL, Varnum MD.

Biochemistry. 2013 Nov 19;52(46):8352-62. doi: 10.1021/bi400824x. Epub 2013 Nov 11.


Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains.

Ding XQ, Fitzgerald JB, Matveev AV, McClellan ME, Elliott MH.

Biochemistry. 2008 Mar 25;47(12):3677-87. doi: 10.1021/bi7019645. Epub 2008 Feb 28.


Cloning and characterization of alpha9 subunits of the nicotinic acetylcholine receptor expressed by saccular hair cells of the rainbow trout (Oncorhynchus mykiss).

Drescher DG, Ramakrishnan NA, Drescher MJ, Chun W, Wang X, Myers SF, Green GE, Sadrazodi K, Karadaghy AA, Poopat N, Karpenko AN, Khan KM, Hatfield JS.

Neuroscience. 2004;127(3):737-52.


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