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Items: 1 to 20 of 81

1.

Synthesis and in vitro and in vivo inhibition potencies of highly relevant nerve agent surrogates.

Meek EC, Chambers HW, Coban A, Funck KE, Pringle RB, Ross MK, Chambers JE.

Toxicol Sci. 2012 Apr;126(2):525-33. doi: 10.1093/toxsci/kfs013. Epub 2012 Jan 12.

PMID:
22247004
2.

Testing of novel brain-penetrating oxime reactivators of acetylcholinesterase inhibited by nerve agent surrogates.

Chambers JE, Chambers HW, Meek EC, Pringle RB.

Chem Biol Interact. 2013 Mar 25;203(1):135-8. doi: 10.1016/j.cbi.2012.10.017. Epub 2012 Nov 2.

PMID:
23123249
3.

Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase.

Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE.

Toxicol Lett. 2016 Apr 25;248:39-45. doi: 10.1016/j.toxlet.2016.03.002. Epub 2016 Mar 7.

4.

Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.

Chambers JE, Chambers HW, Funck KE, Meek EC, Pringle RB, Ross MK.

Chem Biol Interact. 2016 Nov 25;259(Pt B):154-159. doi: 10.1016/j.cbi.2016.07.004. Epub 2016 Jul 5.

PMID:
27387540
5.

The effect of PON1 enhancers on reducing acetylcholinesterase inhibition following organophosphate anticholinesterase exposure in rats.

Meek EC, Chambers HW, Pringle RB, Chambers JE.

Toxicology. 2015 Oct 2;336:79-83. doi: 10.1016/j.tox.2015.08.002. Epub 2015 Aug 11.

PMID:
26275814
6.

Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.

Chambers JE, Meek EC, Bennett JP, Bennett WS, Chambers HW, Leach CA, Pringle RB, Wills RW.

Toxicology. 2016 Jan 2;339:51-7. doi: 10.1016/j.tox.2015.12.001. Epub 2015 Dec 17.

PMID:
26705700
7.

Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Toxicol Mech Methods. 2009 Sep;19(6-7):386-400. doi: 10.1080/15376510903213892.

PMID:
19778239
8.

Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.

Jun D, Musilova L, Kuca K, Kassa J, Bajgar J.

Chem Biol Interact. 2008 Sep 25;175(1-3):421-4. doi: 10.1016/j.cbi.2008.05.004. Epub 2008 May 7.

PMID:
18617161
9.

New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.

Kuca K, Bartosov√° L, Jun D, Patocka J, Cabal J, Kassa J, Kunesov√° G.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):75-82.

10.

Acute tabun toxicity; biochemical and histochemical consequences in brain and skeletal muscles of rat.

Gupta RC, Patterson GT, Dettbarn WD.

Toxicology. 1987 Nov;46(3):329-41.

PMID:
3672538
11.

Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase.

Bartling A, Worek F, Szinicz L, Thiermann H.

Toxicology. 2007 Apr 20;233(1-3):166-72. Epub 2006 Jul 7.

PMID:
16904809
12.

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.

Hrabinova M, Musilek K, Jun D, Kuca K.

J Enzyme Inhib Med Chem. 2006 Oct;21(5):515-9.

PMID:
17194020
13.

[A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun].

Cabal J, Kuca K, Jun D, Bajgar J, Hrabinov√° M.

Ceska Slov Farm. 2005 Jul;54(4):192-5. Czech.

PMID:
16124202
14.

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Chem Biol Interact. 2010 Sep 6;187(1-3):207-14. doi: 10.1016/j.cbi.2010.03.006. Epub 2010 Mar 9.

PMID:
20223229
16.

Comparison of cholinergic and neuromuscular toxicity following acute exposure to sarin and VX in rat.

Gupta RC, Patterson GT, Dettbarn WD.

Fundam Appl Toxicol. 1991 Apr;16(3):449-58.

PMID:
1855618
17.

Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase.

Aurbek N, Thiermann H, Szinicz L, Eyer P, Worek F.

Toxicology. 2006 Jul 5;224(1-2):91-9. Epub 2006 Apr 27.

PMID:
16720069
18.

Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design.

Hammond PI, Kern C, Hong F, Kollmeyer TM, Pang YP, Brimijoin S.

J Pharmacol Exp Ther. 2003 Oct;307(1):190-6. Epub 2003 Jul 31.

19.

Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.

Worek F, Herkert NM, Koller M, Aurbek N, Thiermann H.

Toxicol Lett. 2009 Jun 1;187(2):119-23. doi: 10.1016/j.toxlet.2009.02.010. Epub 2009 Feb 21.

PMID:
19429253
20.

Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.

Mazor O, Cohen O, Kronman C, Raveh L, Stein D, Ordentlich A, Shafferman A.

Mol Pharmacol. 2008 Sep;74(3):755-63. doi: 10.1124/mol.108.047449. Epub 2008 Jun 3.

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