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Items: 1 to 20 of 230

1.

A cyclic peptide inhibitor of apoC-II peptide fibril formation: mechanistic insight from NMR and molecular dynamics analysis.

Griffin MD, Yeung L, Hung A, Todorova N, Mok YF, Karas JA, Gooley PR, Yarovsky I, Howlett GJ.

J Mol Biol. 2012 Mar 9;416(5):642-55. doi: 10.1016/j.jmb.2011.12.059. Epub 2012 Jan 5.

PMID:
22244853
2.

"Janus" cyclic peptides: a new approach to amyloid fibril inhibition?

Todorova N, Yeung L, Hung A, Yarovsky I.

PLoS One. 2013;8(2):e57437. doi: 10.1371/journal.pone.0057437. Epub 2013 Feb 20.

3.

Effects of mutation on the amyloidogenic propensity of apolipoprotein C-II(60-70) peptide.

Todorova N, Hung A, Maaser SM, Griffin MD, Karas J, Howlett GJ, Yarovsky I.

Phys Chem Chem Phys. 2010 Nov 28;12(44):14762-74. doi: 10.1039/c0cp00299b. Epub 2010 Oct 11.

PMID:
20938536
4.

Lipids enhance apolipoprotein C-II-derived amyloidogenic peptide oligomerization but inhibit fibril formation.

Hung A, Griffin MD, Howlett GJ, Yarovsky I.

J Phys Chem B. 2009 Jul 16;113(28):9447-53. doi: 10.1021/jp901051n.

PMID:
19537801
5.

Molecular dynamics simulations of a fibrillogenic peptide derived from apolipoprotein C-II.

Legge FS, Treutlein H, Howlett GJ, Yarovsky I.

Biophys Chem. 2007 Nov;130(3):102-13. Epub 2007 Aug 22.

PMID:
17825978
6.

A structural model for apolipoprotein C-II amyloid fibrils: experimental characterization and molecular dynamics simulations.

Teoh CL, Pham CL, Todorova N, Hung A, Lincoln CN, Lees E, Lam YH, Binger KJ, Thomson NH, Radford SE, Smith TA, Müller SA, Engel A, Griffin MD, Yarovsky I, Gooley PR, Howlett GJ.

J Mol Biol. 2011 Feb 4;405(5):1246-66. doi: 10.1016/j.jmb.2010.12.006. Epub 2010 Dec 10.

PMID:
21146539
7.

Effect of oxidation and mutation on the conformational dynamics and fibril assembly of amyloidogenic peptides derived from apolipoprotein C-II.

Legge FS, Binger KJ, Griffin MD, Howlett GJ, Scanlon D, Treutlein H, Yarovsky I.

J Phys Chem B. 2009 Oct 22;113(42):14006-14. doi: 10.1021/jp903842u.

PMID:
19780547
8.

A structural core within apolipoprotein C-II amyloid fibrils identified using hydrogen exchange and proteolysis.

Wilson LM, Mok YF, Binger KJ, Griffin MD, Mertens HD, Lin F, Wade JD, Gooley PR, Howlett GJ.

J Mol Biol. 2007 Mar 9;366(5):1639-51. Epub 2006 Dec 21.

PMID:
17217959
9.

Methionine oxidation inhibits assembly and promotes disassembly of apolipoprotein C-II amyloid fibrils.

Binger KJ, Griffin MD, Howlett GJ.

Biochemistry. 2008 Sep 23;47(38):10208-17. doi: 10.1021/bi8009339. Epub 2008 Aug 26.

PMID:
18729385
10.

High-affinity amphipathic modulators of amyloid fibril nucleation and elongation.

Ryan TM, Griffin MD, Teoh CL, Ooi J, Howlett GJ.

J Mol Biol. 2011 Feb 25;406(3):416-29. doi: 10.1016/j.jmb.2010.12.023. Epub 2010 Dec 23.

PMID:
21185302
11.

Shear flow induced changes in apolipoprotein C-II conformation and amyloid fibril formation.

Teoh CL, Bekard IB, Asimakis P, Griffin MD, Ryan TM, Dunstan DE, Howlett GJ.

Biochemistry. 2011 May 17;50(19):4046-57. doi: 10.1021/bi2002482. Epub 2011 Apr 22.

PMID:
21476595
12.

Lipid concentration effects on the amyloidogenic apoC-II(60-70) peptide: a computational study.

Todorova N, Hung A, Yarovsky I.

J Phys Chem B. 2010 Jun 17;114(23):7974-82. doi: 10.1021/jp102142x.

PMID:
20496878
13.

Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation.

Stewart CR, Wilson LM, Zhang Q, Pham CL, Waddington LJ, Staples MK, Stapleton D, Kelly JW, Howlett GJ.

Biochemistry. 2007 May 8;46(18):5552-61. Epub 2007 Apr 13.

PMID:
17429947
14.

Cross-linking and amyloid formation by N- and C-terminal cysteine derivatives of human apolipoprotein C-II.

Pham CL, Hatters DM, Lawrence LJ, Howlett GJ.

Biochemistry. 2002 Dec 3;41(48):14313-22.

PMID:
12450397
15.

Hydrogen/Deuterium Exchange and Molecular Dynamics Analysis of Amyloid Fibrils Formed by a D69K Charge-Pair Mutant of Human Apolipoprotein C-II.

Mao Y, Zlatic CO, Griffin MD, Howlett GJ, Todorova N, Yarovsky I, Gooley PR.

Biochemistry. 2015 Aug 11;54(31):4805-14. doi: 10.1021/acs.biochem.5b00535. Epub 2015 Aug 3.

PMID:
26196342
16.

Phospholipid interaction induces molecular-level polymorphism in apolipoprotein C-II amyloid fibrils via alternative assembly pathways.

Griffin MD, Mok ML, Wilson LM, Pham CL, Waddington LJ, Perugini MA, Howlett GJ.

J Mol Biol. 2008 Jan 4;375(1):240-56. Epub 2007 Oct 22.

PMID:
18005990
17.

Structural basis for the recognition and cross-linking of amyloid fibrils by human apolipoprotein E.

Gunzburg MJ, Perugini MA, Howlett GJ.

J Biol Chem. 2007 Dec 7;282(49):35831-41. Epub 2007 Oct 4.

18.

Intra- and Intersubunit Ion-Pair Interactions Determine the Ability of Apolipoprotein C-II Mutants To Form Hybrid Amyloid Fibrils.

Todorova N, Zlatic CO, Mao Y, Yarovsky I, Howlett GJ, Gooley PR, Griffin MD.

Biochemistry. 2017 Mar 28;56(12):1757-1767. doi: 10.1021/acs.biochem.6b01146. Epub 2017 Mar 15.

PMID:
28229588
19.

Inhibition of peptide aggregation by lipids: insights from coarse-grained molecular simulations.

Hung A, Yarovsky I.

J Mol Graph Model. 2011 Feb;29(5):597-607. doi: 10.1016/j.jmgm.2010.11.001. Epub 2010 Nov 11.

PMID:
21146432
20.

Fluorescence detection of a lipid-induced tetrameric intermediate in amyloid fibril formation by apolipoprotein C-II.

Ryan TM, Howlett GJ, Bailey MF.

J Biol Chem. 2008 Dec 12;283(50):35118-28. doi: 10.1074/jbc.M804004200. Epub 2008 Oct 13.

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