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Items: 1 to 20 of 209

1.

Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.

Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Jan 24;51(3):776-85. doi: 10.1021/bi2017427. Epub 2012 Jan 12.

2.

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.

Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Apr 10;51(14):3031-8. doi: 10.1021/bi300257e. Epub 2012 Mar 28.

PMID:
22413858
3.

Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

J Phys Chem B. 2013 Oct 3;117(39):11518-29. doi: 10.1021/jp405389n. Epub 2013 Sep 13.

4.

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology.

Connelly L, Jang H, Arce FT, Capone R, Kotler SA, Ramachandran S, Kagan BL, Nussinov R, Lal R.

J Phys Chem B. 2012 Feb 9;116(5):1728-35. doi: 10.1021/jp2108126. Epub 2012 Jan 25.

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6.

Interactions of Aβ25-35 β-barrel-like oligomers with anionic lipid bilayer and resulting membrane leakage: an all-atom molecular dynamics study.

Chang Z, Luo Y, Zhang Y, Wei G.

J Phys Chem B. 2011 Feb 10;115(5):1165-74. doi: 10.1021/jp107558e. Epub 2010 Dec 30.

PMID:
21192698
7.

Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding.

Xu L, Chen Y, Wang X.

Proteins. 2014 Dec;82(12):3286-97. doi: 10.1002/prot.24669. Epub 2014 Oct 21.

PMID:
25137638
8.

Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.

Yu X, Wang Q, Pan Q, Zhou F, Zheng J.

Phys Chem Chem Phys. 2013 Jun 21;15(23):8878-89. doi: 10.1039/c3cp44448a. Epub 2013 Mar 14.

9.

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.

Jang H, Arce FT, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Chem Soc Rev. 2014 Oct 7;43(19):6750-64. doi: 10.1039/c3cs60459d. Review.

10.

Stability of transmembrane amyloid β-peptide and membrane integrity tested by molecular modeling of site-specific Aβ42 mutations.

Poojari C, Strodel B.

PLoS One. 2013 Nov 7;8(11):e78399. doi: 10.1371/journal.pone.0078399. eCollection 2013.

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13.

Activity and architecture of pyroglutamate-modified amyloid-β (AβpE3-42) pores.

Gillman AL, Jang H, Lee J, Ramachandran S, Kagan BL, Nussinov R, Teran Arce F.

J Phys Chem B. 2014 Jul 3;118(26):7335-44. doi: 10.1021/jp5040954. Epub 2014 Jun 24.

14.

Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels.

Tofoleanu F, Buchete NV.

Prion. 2012 Sep-Oct;6(4):339-45. doi: 10.4161/pri.21022. Epub 2012 Aug 9.

15.

Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Methods Mol Biol. 2016;1345:251-68. doi: 10.1007/978-1-4939-2978-8_16.

PMID:
26453217
16.

β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R.

J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21.

PMID:
20970427
17.

Free energy of lipid bilayer defects affected by Alzheimer's disease-associated amyloid-β42 monomers.

Pobandt T, Knecht V.

J Phys Chem B. 2014 Apr 3;118(13):3507-16. doi: 10.1021/jp410477x. Epub 2014 Mar 20.

PMID:
24597727
18.

Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts.

Lee J, Kim YH, T Arce F, Gillman AL, Jang H, Kagan BL, Nussinov R, Yang J, Lal R.

ACS Chem Neurosci. 2017 Jun 21;8(6):1348-1357. doi: 10.1021/acschemneuro.7b00006. Epub 2017 Feb 20.

PMID:
28135799
19.

Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.

Zheng X, Liu D, Roychaudhuri R, Teplow DB, Bowers MT.

ACS Chem Neurosci. 2015 Oct 21;6(10):1732-40. doi: 10.1021/acschemneuro.5b00171. Epub 2015 Aug 12.

20.

Ion Channel Formation by Amyloid-β42 Oligomers but Not Amyloid-β40 in Cellular Membranes.

Bode DC, Baker MD, Viles JH.

J Biol Chem. 2017 Jan 27;292(4):1404-1413. doi: 10.1074/jbc.M116.762526. Epub 2016 Dec 7.

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