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Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation.

Meunier S, Rapetti L, Beziaud L, Pontoux C, Legrand A, Tanchot C.

J Leukoc Biol. 2012 Jun;91(6):859-69. doi: 10.1189/jlb.0611292. Epub 2012 Jan 11.


A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.

Bourgeois C, Rocha B, Tanchot C.

Science. 2002 Sep 20;297(5589):2060-3.


Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.

Jackaman C, Nelson DJ.

Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15.


The development of functional CD8 T cell memory after Listeria monocytogenes infection is not dependent on CD40.

Montfort MJ, Bouwer HG, Wagner CR, Hinrichs DJ.

J Immunol. 2004 Sep 15;173(6):4084-90.


Cutting edge: a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs.

Taraban VY, Rowley TF, Al-Shamkhani A.

J Immunol. 2004 Dec 1;173(11):6542-6.


CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

Oxenius A, Campbell KA, Maliszewski CR, Kishimoto T, Kikutani H, Hengartner H, Zinkernagel RM, Bachmann MF.

J Exp Med. 1996 May 1;183(5):2209-18.


CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells.

Koschella M, Voehringer D, Pircher H.

J Immunol. 2004 Apr 15;172(8):4804-11.


CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements.

Rapetti L, Meunier S, Pontoux C, Tanchot C.

J Immunol. 2008 Jul 1;181(1):299-308.


The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity.

Clarke SR.

J Leukoc Biol. 2000 May;67(5):607-14. Review.


Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.

Ryu SJ, Jung KM, Yoo HS, Kim TW, Kim S, Chang J, Choi EY.

Blood. 2009 Apr 30;113(18):4273-80. doi: 10.1182/blood-2008-09-181263. Epub 2009 Jan 12.


Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells.

Liu Z, Tugulea S, Cortesini R, Lederman S, Suciu-Foca N.

Hum Immunol. 1999 Jul;60(7):568-74.


CD4+ and CD8+ T cell priming for contact hypersensitivity occurs independently of CD40-CD154 interactions.

Gorbachev AV, Heeger PS, Fairchild RL.

J Immunol. 2001 Feb 15;166(4):2323-32.


CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells.

Ribas A, Butterfield LH, Amarnani SN, Dissette VB, Kim D, Meng WS, Miranda GA, Wang HJ, McBride WH, Glaspy JA, Economou JS.

Cancer Res. 2001 Dec 15;61(24):8787-93.


Direct CD4 help provision following interaction of memory CD4 and CD8 T cells with distinct antigen-presenting dendritic cells.

de Goër de Herve MG, Dembele B, Vallée M, Herr F, Cariou A, Taoufik Y.

J Immunol. 2010 Jul 15;185(2):1028-36. doi: 10.4049/jimmunol.0904209. Epub 2010 Jun 18.


Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.

Shedlock DJ, Whitmire JK, Tan J, MacDonald AS, Ahmed R, Shen H.

J Immunol. 2003 Feb 15;170(4):2053-63.

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