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Items: 1 to 20 of 212

1.

Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.

Anderson KA, Lin F, Ribar TJ, Stevens RD, Muehlbauer MJ, Newgard CB, Means AR.

Mol Endocrinol. 2012 Feb;26(2):281-91. doi: 10.1210/me.2011-1299. Epub 2012 Jan 12.

2.

Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.

Racioppi L, Noeldner PK, Lin F, Arvai S, Means AR.

J Biol Chem. 2012 Mar 30;287(14):11579-91. doi: 10.1074/jbc.M111.336032. Epub 2012 Feb 14.

3.

Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake.

Gao XF, Chen W, Kong XP, Xu AM, Wang ZG, Sweeney G, Wu D.

Diabetologia. 2009 May;52(5):912-20. doi: 10.1007/s00125-009-1284-0. Epub 2009 Feb 18.

PMID:
19224198
4.

Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity.

Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina YA, Gibson M, Berglund ED, Justice NJ, Berdeaux R.

Mol Metab. 2015 Nov 6;5(1):34-46. doi: 10.1016/j.molmet.2015.10.004. eCollection 2016 Jan.

5.

Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction.

Kujiraoka T, Satoh Y, Ayaori M, Shiraishi Y, Arai-Nakaya Y, Hakuno D, Yada H, Kuwada N, Endo S, Isoda K, Adachi T.

J Am Heart Assoc. 2013 Aug 16;2(4):e000361. doi: 10.1161/JAHA.113.000361.

6.

Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice.

Romanatto T, Fiamoncini J, Wang B, Curi R, Kang JX.

Biochim Biophys Acta. 2014 Feb;1842(2):186-91. doi: 10.1016/j.bbadis.2013.10.017. Epub 2013 Nov 7.

7.

Gluconeogenic signals regulate iron homeostasis via hepcidin in mice.

Vecchi C, Montosi G, Garuti C, Corradini E, Sabelli M, Canali S, Pietrangelo A.

Gastroenterology. 2014 Apr;146(4):1060-9. doi: 10.1053/j.gastro.2013.12.016. Epub 2013 Dec 17.

8.

Loss of CTRP1 disrupts glucose and lipid homeostasis.

Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW.

Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E678-E697. doi: 10.1152/ajpendo.00087.2016. Epub 2016 Aug 23.

PMID:
27555298
9.

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

Sajan MP, Ivey RA 3rd, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV.

Mol Endocrinol. 2014 Jul;28(7):1097-107. doi: 10.1210/me.2014-1025. Epub 2014 May 30.

10.

Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα.

London E, Nesterova M, Sinaii N, Szarek E, Chanturiya T, Mastroyannis SA, Gavrilova O, Stratakis CA.

Endocrinology. 2014 Sep;155(9):3397-408. doi: 10.1210/en.2014-1122. Epub 2014 Jun 10.

11.

Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet.

Wada T, Kenmochi H, Miyashita Y, Sasaki M, Ojima M, Sasahara M, Koya D, Tsuneki H, Sasaoka T.

Endocrinology. 2010 May;151(5):2040-9. doi: 10.1210/en.2009-0869. Epub 2010 Mar 8.

PMID:
20211973
12.

Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice.

Meng R, Zhu D, Bi Y, Yang D, Wang Y.

PLoS One. 2013;8(1):e53557. doi: 10.1371/journal.pone.0053557. Epub 2013 Jan 10.

13.

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.

Peyrou M, Bourgoin L, Poher AL, Altirriba J, Maeder C, Caillon A, Fournier M, Montet X, Rohner-Jeanrenaud F, Foti M.

J Hepatol. 2015 Feb;62(2):421-9. doi: 10.1016/j.jhep.2014.09.012. Epub 2014 Sep 16.

PMID:
25234947
14.

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Bernsmeier C, Dill MT, Provenzano A, Makowska Z, Krol I, Muscogiuri G, Semela D, Tornillo L, Marra F, Heim MH, Duong FH.

Lab Invest. 2016 Sep;96(9):972-80. doi: 10.1038/labinvest.2016.75. Epub 2016 Jul 18.

PMID:
27428080
15.

Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice.

Naowaboot J, Piyabhan P, Munkong N, Parklak W, Pannangpetch P.

Clin Exp Pharmacol Physiol. 2016 Feb;43(2):242-50. doi: 10.1111/1440-1681.12514.

PMID:
26541794
16.

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.

Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK.

Diabetes. 2009 Mar;58(3):590-9. doi: 10.2337/db08-0913. Epub 2008 Dec 15.

17.

PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.

Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR.

J Clin Invest. 2011 Jun;121(6):2504-17. doi: 10.1172/JCI46045. Epub 2011 May 16.

18.

Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice.

Cao M, Pan Q, Dong H, Yuan X, Li Y, Sun Z, Dong X, Wang H.

Stem Cell Res Ther. 2015 Oct 31;6:208. doi: 10.1186/s13287-015-0201-3.

19.

Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.

Shi SY, Martin RG, Duncan RE, Choi D, Lu SY, Schroer SA, Cai EP, Luk CT, Hopperton KE, Domenichiello AF, Tang C, Naples M, Dekker MJ, Giacca A, Adeli K, Wagner KU, Bazinet RP, Woo M.

J Biol Chem. 2012 Mar 23;287(13):10277-88. doi: 10.1074/jbc.M111.317453. Epub 2012 Jan 24.

20.

Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice.

Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM.

Food Chem Toxicol. 2014 Feb;64:94-103. doi: 10.1016/j.fct.2013.11.015. Epub 2013 Nov 22.

PMID:
24275089

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