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Items: 1 to 20 of 99

1.

The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge B2a of the ribosome.

Bulkley D, Johnson F, Steitz TA.

J Mol Biol. 2012 Mar 2;416(4):571-8. doi: 10.1016/j.jmb.2011.12.055. Epub 2012 Jan 2.

2.

Bactobolin A binds to a site on the 70S ribosome distinct from previously seen antibiotics.

Amunts A, Fiedorczuk K, Truong TT, Chandler J, Peter Greenberg E, Ramakrishnan V.

J Mol Biol. 2015 Feb 27;427(4):753-755. doi: 10.1016/j.jmb.2014.12.018. Epub 2015 Jan 3.

3.

Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.

Polikanov YS, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, Steitz TA, Vázquez-Laslop N, Mankin AS.

Mol Cell. 2014 Nov 20;56(4):541-50. doi: 10.1016/j.molcel.2014.09.021. Epub 2014 Oct 9.

4.

Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.

Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9.

5.

Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome.

Blaha G, Stanley RE, Steitz TA.

Science. 2009 Aug 21;325(5943):966-70. doi: 10.1126/science.1175800.

6.

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.

7.

Structural Insights into ribosome recycling factor interactions with the 70S ribosome.

Pai RD, Zhang W, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate JH.

J Mol Biol. 2008 Mar 7;376(5):1334-47. doi: 10.1016/j.jmb.2007.12.048. Epub 2008 Jan 3.

8.

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.

Seefeldt AC, Nguyen F, Antunes S, Pérébaskine N, Graf M, Arenz S, Inampudi KK, Douat C, Guichard G, Wilson DN, Innis CA.

Nat Struct Mol Biol. 2015 Jun;22(6):470-5. doi: 10.1038/nsmb.3034. Epub 2015 May 18.

PMID:
25984971
9.

Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity.

Kipper K, Hetényi C, Sild S, Remme J, Liiv A.

J Mol Biol. 2009 Jan 16;385(2):405-22. doi: 10.1016/j.jmb.2008.10.065. Epub 2008 Nov 5.

PMID:
19007789
10.

Ribosome engineering to promote new crystal forms.

Selmer M, Gao YG, Weixlbaumer A, Ramakrishnan V.

Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):578-83. doi: 10.1107/S0907444912006348. Epub 2012 Apr 17.

11.

On the specificity of antibiotics targeting the large ribosomal subunit.

Wilson DN.

Ann N Y Acad Sci. 2011 Dec;1241:1-16. doi: 10.1111/j.1749-6632.2011.06192.x. Review.

PMID:
22191523
12.

Allosteric control of the ribosome by small-molecule antibiotics.

Wang L, Pulk A, Wasserman MR, Feldman MB, Altman RB, Cate JH, Blanchard SC.

Nat Struct Mol Biol. 2012 Sep;19(9):957-63. doi: 10.1038/nsmb.2360. Epub 2012 Aug 19.

13.

The protein synthesis inhibitor thermorubin. 2. Mechanism of inhibition of initiation on Escherichia coli ribosomes.

Lin F, Wishnia A.

Biochemistry. 1982 Feb 2;21(3):484-91. No abstract available.

PMID:
7039672
14.

Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state.

Fagan CE, Dunkle JA, Maehigashi T, Dang MN, Devaraj A, Miles SJ, Qin D, Fredrick K, Dunham CM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9716-21. doi: 10.1073/pnas.1301585110. Epub 2013 Apr 29.

15.

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.

Jenner L, Starosta AL, Terry DS, Mikolajka A, Filonava L, Yusupov M, Blanchard SC, Wilson DN, Yusupova G.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3812-6. doi: 10.1073/pnas.1216691110. Epub 2013 Feb 19.

16.

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15656-61. doi: 10.1073/pnas.1309578110. Epub 2013 Sep 12.

17.

Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.

Seefeldt AC, Graf M, Pérébaskine N, Nguyen F, Arenz S, Mardirossian M, Scocchi M, Wilson DN, Innis CA.

Nucleic Acids Res. 2016 Mar 18;44(5):2429-38. doi: 10.1093/nar/gkv1545. Epub 2016 Jan 20.

18.

Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome.

Svidritskiy E, Ling C, Ermolenko DN, Korostelev AA.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12283-8. doi: 10.1073/pnas.1304922110. Epub 2013 Jul 3.

19.

Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Olivier NB, Altman RB, Noeske J, Basarab GS, Code E, Ferguson AD, Gao N, Huang J, Juette MF, Livchak S, Miller MD, Prince DB, Cate JH, Buurman ET, Blanchard SC.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16274-9. doi: 10.1073/pnas.1414401111. Epub 2014 Nov 3.

20.

Crystal structure of a translation termination complex formed with release factor RF2.

Korostelev A, Asahara H, Lancaster L, Laurberg M, Hirschi A, Zhu J, Trakhanov S, Scott WG, Noller HF.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19684-9. doi: 10.1073/pnas.0810953105. Epub 2008 Dec 8.

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