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Enhancement of lung tumorigenesis in a Gprc5a Knockout mouse by chronic extrinsic airway inflammation.

Barta P, Van Pelt C, Men T, Dickey BF, Lotan R, Moghaddam SJ.

Mol Cancer. 2012 Jan 12;11:4. doi: 10.1186/1476-4598-11-4.


Comparative functional genomics analysis of NNK tobacco-carcinogen induced lung adenocarcinoma development in Gprc5a-knockout mice.

Fujimoto J, Kadara H, Men T, van Pelt C, Lotan D, Lotan R.

PLoS One. 2010 Jul 29;5(7):e11847. doi: 10.1371/journal.pone.0011847.


Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.

Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF.

Carcinogenesis. 2009 Nov;30(11):1949-56. doi: 10.1093/carcin/bgp229. Epub 2009 Sep 30.


Knockout of the tumor suppressor gene Gprc5a in mice leads to NF-kappaB activation in airway epithelium and promotes lung inflammation and tumorigenesis.

Deng J, Fujimoto J, Ye XF, Men TY, Van Pelt CS, Chen YL, Lin XF, Kadara H, Tao Q, Lotan D, Lotan R.

Cancer Prev Res (Phila). 2010 Apr;3(4):424-37. doi: 10.1158/1940-6207.CAPR-10-0032. Epub 2010 Mar 30.


Combined exposure to bacteria and cigarette smoke resembles characteristic phenotypes of human COPD in a murine disease model.

Herr C, Han G, Li D, Tschernig T, Dinh QT, Beißwenger C, Bals R.

Exp Toxicol Pathol. 2015 Mar;67(3):261-9. doi: 10.1016/j.etp.2015.01.002. Epub 2015 Jan 16.


Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis.

Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ.

Cancer Prev Res (Phila). 2011 Jan;4(1):51-64. doi: 10.1158/1940-6207.CAPR-10-0180. Epub 2010 Nov 22.


Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure.

Wang X, Xu D, Liao Y, Zhong S, Song H, Sun B, Zhou BP, Deng J, Han B.

Oncotarget. 2015 Nov 24;6(37):39578-93. doi: 10.18632/oncotarget.5532.


Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.

Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ.

Am J Respir Cell Mol Biol. 2009 Apr;40(4):443-53. doi: 10.1165/rcmb.2008-0198OC. Epub 2008 Oct 16.


G-protein coupled receptor family C, group 5, member A (GPRC5A) expression is decreased in the adjacent field and normal bronchial epithelia of patients with chronic obstructive pulmonary disease and non-small-cell lung cancer.

Fujimoto J, Kadara H, Garcia MM, Kabbout M, Behrens C, Liu DD, Lee JJ, Solis LM, Kim ES, Kalhor N, Moran C, Sharafkhaneh A, Lotan R, Wistuba II.

J Thorac Oncol. 2012 Dec;7(12):1747-54. doi: 10.1097/JTO.0b013e31826bb1ff.


Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer.

Moghaddam SJ, Ochoa CE, Sethi S, Dickey BF.

Int J Chron Obstruct Pulmon Dis. 2011;6:113-23. doi: 10.2147/COPD.S15417. Epub 2011 Jan 27. Review.


Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.

Tao Q, Fujimoto J, Men T, Ye X, Deng J, Lacroix L, Clifford JL, Mao L, Van Pelt CS, Lee JJ, Lotan D, Lotan R.

J Natl Cancer Inst. 2007 Nov 21;99(22):1668-82. Epub 2007 Nov 13.


Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.

Chen Y, Deng J, Fujimoto J, Kadara H, Men T, Lotan D, Lotan R.

Cancer Res. 2010 Nov 1;70(21):8917-26. doi: 10.1158/0008-5472.CAN-10-0518. Epub 2010 Oct 19.


Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice.

Ganesan S, Comstock AT, Kinker B, Mancuso P, Beck JM, Sajjan US.

Respir Res. 2014 Feb 4;15:11. doi: 10.1186/1465-9921-15-11.


Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.

Liao Y, Song H, Xu D, Jiao H, Yao F, Liu J, Wu Y, Zhong S, Yin H, Liu S, Wang X, Guo W, Sun B, Han B, Chin YE, Deng J.

Cell Cycle. 2015;14(9):1403-12. doi: 10.1080/15384101.2015.1006006.


Cigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in mice.

Voss M, Wonnenberg B, Honecker A, Kamyschnikow A, Herr C, Bischoff M, Tschernig T, Bals R, Beisswenger C.

Respir Res. 2015 Mar 20;16:41. doi: 10.1186/s12931-015-0204-8.


Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

Staples KJ, Taylor S, Thomas S, Leung S, Cox K, Pascal TG, Ostridge K, Welch L, Tuck AC, Clarke SC, Gorringe A, Wilkinson TM.

PLoS One. 2016 Nov 29;11(11):e0167250. doi: 10.1371/journal.pone.0167250. eCollection 2016. Erratum in: PLoS One. 2017 Apr 25;12 (4):e0176749.


Mechanisms of clearance of nontypeable Haemophilus influenzae from cigarette smoke-exposed mouse lungs.

Gaschler GJ, Zavitz CC, Bauer CM, Stämpfli MR.

Eur Respir J. 2010 Nov;36(5):1131-42. doi: 10.1183/09031936.00113909. Epub 2010 Apr 22.


Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype.

Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF.

Am J Respir Cell Mol Biol. 2008 Jun;38(6):629-38. Epub 2007 Dec 20.


IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Roos AB, Sethi S, Nikota J, Wrona CT, Dorrington MG, Sandén C, Bauer CM, Shen P, Bowdish D, Stevenson CS, Erjefält JS, Stampfli MR.

Am J Respir Crit Care Med. 2015 Aug 15;192(4):428-37. doi: 10.1164/rccm.201409-1689OC.


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