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Items: 1 to 20 of 100

1.

Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes.

Krishnan S, Mali RS, Koehler KR, Vemula S, Chatterjee A, Ghosh J, Ramdas B, Ma P, Hashino E, Kapur R.

PLoS One. 2012;7(1):e28979. doi: 10.1371/journal.pone.0028979. Epub 2012 Jan 4.

2.

Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation.

Ma P, Vemula S, Munugalavadla V, Chen J, Sims E, Borneo J, Kondo T, Ramdas B, Mali RS, Li S, Hashino E, Takemoto C, Kapur R.

Mol Cell Biol. 2011 Oct;31(19):4052-62. doi: 10.1128/MCB.05750-11. Epub 2011 Jul 26.

3.

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.

Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R.

Blood. 2011 Sep 29;118(13):3459-69. doi: 10.1182/blood-2011-04-351809. Epub 2011 Jul 25.

4.

p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.

Krishnan S, Mali RS, Ramdas B, Sims E, Ma P, Ghosh J, Munugalavadla V, Hanneman P, Beane JD, Kapur R.

Blood. 2012 Apr 26;119(17):3951-61. doi: 10.1182/blood-2011-05-355602. Epub 2012 Feb 29.

5.

Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR.

J Biol Chem. 2000 Feb 25;275(8):6022-9.

6.

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.

Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC.

Mol Cell Biol. 2005 Apr;25(7):2593-606.

7.

Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.

Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D.

J Biol Chem. 2003 Feb 14;278(7):5099-108. Epub 2002 Nov 14.

8.

p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.

Wu X, Chen S, Orlando SA, Yuan J, Kim ET, Munugalavadla V, Mali RS, Kapur R, Yang FC.

J Biol Chem. 2011 Apr 15;286(15):13512-21. doi: 10.1074/jbc.M110.187351. Epub 2011 Feb 15.

9.

Differential signaling by regulatory subunits of phosphoinositide-3-kinase influences cell survival in INS-1E insulinoma cells.

Schrader J, Niebel P, Rossi A, Archontidou-Aprin E, Hörsch D.

Exp Clin Endocrinol Diabetes. 2015 Feb;123(2):118-25. doi: 10.1055/s-0034-1390461. Epub 2014 Nov 13.

PMID:
25393342
10.

Class I PI3K-mediated Akt and ERK signals play a critical role in FcεRI-induced degranulation in mast cells.

Takayama G, Ohtani M, Minowa A, Matsuda S, Koyasu S.

Int Immunol. 2013 Apr;25(4):215-20. doi: 10.1093/intimm/dxs105. Epub 2012 Nov 8.

PMID:
23143475
11.

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24. Epub 2001 Dec 18.

12.

The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration.

Munugalavadla V, Vemula S, Sims EC, Krishnan S, Chen S, Yan J, Li H, Niziolek PJ, Takemoto C, Robling AG, Yang FC, Kapur R.

Mol Cell Biol. 2008 Dec;28(23):7182-98. doi: 10.1128/MCB.00920-08. Epub 2008 Sep 22.

13.

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA.

Blood. 2007 Apr 1;109(7):2894-902.

14.

Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells.

Hofmann BT, Hoxha E, Mohr E, Schulz K, Jücker M.

Leuk Lymphoma. 2011 Mar;52(3):467-77. doi: 10.3109/10428194.2010.530360. Epub 2010 Nov 15.

PMID:
21077741
15.

The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.

Di Zazzo E, Feola A, Zuchegna C, Romano A, Donini CF, Bartollino S, Costagliola C, Frunzio R, Laccetti P, Di Domenico M, Porcellini A.

ScientificWorldJournal. 2014;2014:565839. doi: 10.1155/2014/565839. Epub 2014 Jul 9.

16.

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.

Mellor P, Furber LA, Nyarko JN, Anderson DH.

Biochem J. 2012 Jan 1;441(1):23-37. doi: 10.1042/BJ20111164. Review.

PMID:
22168437
18.

Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K.

Conley ME, Dobbs AK, Quintana AM, Bosompem A, Wang YD, Coustan-Smith E, Smith AM, Perez EE, Murray PJ.

J Exp Med. 2012 Mar 12;209(3):463-70. doi: 10.1084/jem.20112533. Epub 2012 Feb 20.

19.

Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation.

Takahashi H, Okamura D, Starr ME, Saito H, Evers BM.

Aging Cell. 2012 Apr;11(2):305-14. doi: 10.1111/j.1474-9726.2011.00787.x. Epub 2012 Feb 1.

20.

The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells.

Oak JS, Chen J, Peralta RQ, Deane JA, Fruman DA.

Autoimmunity. 2009 Aug;42(5):447-58.

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