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Items: 1 to 20 of 149


Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Suchiman HE, Jacobsen R, McGue M, Stevnsner T, Bohr VA, de Craen AJ, Westendorp RG, Schreiber S, Slagboom PE, Nebel A, Vaupel JW, Christensen K, Christiansen L.

Age (Dordr). 2013 Apr;35(2):487-500. doi: 10.1007/s11357-011-9373-7. Epub 2012 Jan 12.


Genetic variation and human longevity.

Soerensen M.

Dan Med J. 2012 May;59(5):B4454.


Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.

Sun L, Hu C, Zheng C, Huang Z, Lv Z, Huang J, Liang S, Shi X, Zhu X, Yuan H, Yang Z.

Exp Gerontol. 2014 Jul;55:129-33. doi: 10.1016/j.exger.2014.04.003. Epub 2014 Apr 16.


No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes.

Soerensen M, Nygaard M, Debrabant B, Mengel-From J, Dato S, Thinggaard M, Christensen K, Christiansen L.

Exp Gerontol. 2016 Jun;78:57-61. doi: 10.1016/j.exger.2016.03.001. Epub 2016 Mar 3.


Trans-ethnical shift of the risk genotype in the CETP I405V with longevity: a Chinese case-control study and meta-analysis.

Sun L, Hu CY, Shi XH, Zheng CG, Huang ZZ, Lv ZP, Huang J, Wan G, Qi KY, Liang SY, Zhou L, Yang Z.

PLoS One. 2013 Aug 15;8(8):e72537. doi: 10.1371/journal.pone.0072537. eCollection 2013.


Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

Deelen J, Beekman M, Uh HW, Helmer Q, Kuningas M, Christiansen L, Kremer D, van der Breggen R, Suchiman HE, Lakenberg N, van den Akker EB, Passtoors WM, Tiemeier H, van Heemst D, de Craen AJ, Rivadeneira F, de Geus EJ, Perola M, van der Ouderaa FJ, Gunn DA, Boomsma DI, Uitterlinden AG, Christensen K, van Duijn CM, Heijmans BT, Houwing-Duistermaat JJ, Westendorp RG, Slagboom PE.

Aging Cell. 2011 Aug;10(4):686-98. doi: 10.1111/j.1474-9726.2011.00705.x. Epub 2011 May 6.


Lack of replication of genetic associations with human longevity.

Novelli V, Viviani Anselmi C, Roncarati R, Guffanti G, Malovini A, Piluso G, Puca AA.

Biogerontology. 2008 Apr;9(2):85-92. Epub 2007 Nov 23.


Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians.

Capurso C, Solfrizzi V, D'Introno A, Colacicco AM, Capurso SA, Semeraro C, Capurso A, Panza F.

Ann Hum Genet. 2007 Nov;71(Pt 6):843-8. Epub 2007 May 15.


Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.

Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L.

Aging Cell. 2010 Dec;9(6):1010-7. doi: 10.1111/j.1474-9726.2010.00627.x. Epub 2010 Oct 21.


Association study of promoter polymorphisms in the CETP gene with longevity in the Han Chinese population.

Yang JK, Gong YY, Xie L, Yang Y, Xu LY, Zhang YP.

Mol Biol Rep. 2014 Jan;41(1):325-9. doi: 10.1007/s11033-013-2865-z. Epub 2013 Nov 17.


APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.

Napolioni V, Giannì P, Carpi FM, Predazzi IM, Lucarini N.

Clin Chim Acta. 2011 Sep 18;412(19-20):1821-4. doi: 10.1016/j.cca.2011.06.012. Epub 2011 Jun 16.


Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Soerensen M, Dato S, Tan Q, Thinggaard M, Kleindorp R, Beekman M, Jacobsen R, Suchiman HE, de Craen AJ, Westendorp RG, Schreiber S, Stevnsner T, Bohr VA, Slagboom PE, Nebel A, Vaupel JW, Christensen K, McGue M, Christiansen L.

Exp Gerontol. 2012 May;47(5):379-87. doi: 10.1016/j.exger.2012.02.010. Epub 2012 Mar 3.


The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population.

Sorlí JV, Corella D, Francés F, Ramírez JB, González JI, Guillén M, Portolés O.

Clin Chim Acta. 2006 Apr;366(1-2):196-203. Epub 2006 Jan 19.


Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese.

Chen DW, Yang JF, Tang Z, Dong XM, Feng XL, Yu S, Chan P.

Brain Res. 2008 Jan 2;1187:52-7. Epub 2007 Nov 26.


Rare and common variants in the Apolipoprotein E gene in healthy oldest old.

Tindale LC, Leach S, Ushey K, Daley D, Brooks-Wilson AR.

Neurobiol Aging. 2014 Mar;35(3):727.e1-3. doi: 10.1016/j.neurobiolaging.2013.09.010. Epub 2013 Oct 11.


A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.

Nebel A, Kleindorp R, Caliebe A, Nothnagel M, Blanché H, Junge O, Wittig M, Ellinghaus D, Flachsbart F, Wichmann HE, Meitinger T, Nikolaus S, Franke A, Krawczak M, Lathrop M, Schreiber S.

Mech Ageing Dev. 2011 Jun-Jul;132(6-7):324-30. doi: 10.1016/j.mad.2011.06.008. Epub 2011 Jun 29.


Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.

Sanders AE, Wang C, Katz M, Derby CA, Barzilai N, Ozelius L, Lipton RB.

JAMA. 2010 Jan 13;303(2):150-8. doi: 10.1001/jama.2009.1988.


Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles.

Capurso C, Solfrizzi V, D'Introno A, Colacicco AM, Capurso SA, Semeraro C, Capurso A, Panza F.

Exp Gerontol. 2004 Jul;39(7):1109-14.


Genetic landscape of APOE in human longevity revealed by high-throughput sequencing.

Ryu S, Atzmon G, Barzilai N, Raghavachari N, Suh Y.

Mech Ageing Dev. 2016 Apr;155:7-9. doi: 10.1016/j.mad.2016.02.010. Epub 2016 Feb 27.


Cholesterol ester transfer protein and apolipoprotein E gene polymorphisms in hyperlipidemic Asian Indians in North India.

Meena K, Misra A, Vikram N, Ali S, Pandey RM, Luthra K.

Mol Cell Biochem. 2011 Jun;352(1-2):189-96. doi: 10.1007/s11010-011-0753-1. Epub 2011 Mar 6.


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