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Items: 1 to 20 of 90

1.

Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis.

Ruiz-Heiland G, Horn A, Zerr P, Hofstetter W, Baum W, Stock M, Distler JH, Nimmerjahn F, Schett G, Zwerina J.

Ann Rheum Dis. 2012 Mar;71(3):400-7. doi: 10.1136/ard.2010.148262.

PMID:
22233602
2.

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.

Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G, Distler JH.

Ann Rheum Dis. 2012 May;71(5):785-9. doi: 10.1136/annrheumdis-2011-200883.

PMID:
22402139
3.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.

J Hepatol. 2014 Jan;60(1):143-51. doi: 10.1016/j.jhep.2013.08.012.

PMID:
23978713
4.

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease.

Zerr P, Palumbo-Zerr K, Distler A, Tomcik M, Vollath S, Munoz LE, Beyer C, Dees C, Egberts F, Tinazzi I, Del Galdo F, Distler O, Schett G, Spriewald BM, Distler JH.

Blood. 2012 Oct 4;120(14):2909-17. doi: 10.1182/blood-2012-01-403428.

5.

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure.

Kimura H, Ng JM, Curran T.

Cancer Cell. 2008 Mar;13(3):249-60. doi: 10.1016/j.ccr.2008.01.027.

6.

Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs.

Akiyama H, Shigeno C, Iyama K, Ito H, Hiraki Y, Konishi J, Nakamura T.

Biochem Biophys Res Commun. 1999 Apr 21;257(3):814-20.

PMID:
10208865
7.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035.

8.

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

Mak KK, Kronenberg HM, Chuang PT, Mackem S, Yang Y.

Development. 2008 Jun;135(11):1947-56. doi: 10.1242/dev.018044.

9.
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11.

Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.

Joosten LA, Lubberts E, Helsen MM, Saxne T, Coenen-de Roo CJ, HeinegÄrd D, van den Berg WB.

Arthritis Res. 1999;1(1):81-91.

12.

Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5.

Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, Konishi J, Nakamura T.

Biochem Biophys Res Commun. 1997 Jun 9;235(1):142-7.

PMID:
9196051
13.

Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin.

Makinodan E, Marneros AG.

Exp Dermatol. 2012 Nov;21(11):847-52. doi: 10.1111/exd.12016.

PMID:
23163650
14.

Inducible chondrocyte-specific overexpression of BMP2 in young mice results in severe aggravation of osteophyte formation in experimental OA without altering cartilage damage.

Blaney Davidson EN, Vitters EL, Bennink MB, van Lent PL, van Caam AP, Blom AB, van den Berg WB, van de Loo FA, van der Kraan PM.

Ann Rheum Dis. 2015 Jun;74(6):1257-64. doi: 10.1136/annrheumdis-2013-204528.

PMID:
24448347
15.

Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms.

Fendrich V, Wiese D, Waldmann J, Lauth M, Heverhagen AE, Rehm J, Bartsch DK.

Ann Surg. 2011 Nov;254(5):818-23; discussion 823. doi: 10.1097/SLA.0b013e318236bc0f.

PMID:
22042473
17.

Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.

Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL.

Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480.

PMID:
25180294
18.

Smoothened as a new therapeutic target for human osteosarcoma.

Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, Kunigou O, Komiya S.

Mol Cancer. 2010 Jan 12;9:5. doi: 10.1186/1476-4598-9-5.

20.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

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