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Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities.

Fredriksson L, Nilsson I, Su EJ, Andrae J, Ding H, Betsholtz C, Eriksson U, Lawrence DA.

Am J Pathol. 2012 Mar;180(3):1136-44. doi: 10.1016/j.ajpath.2011.12.006. Epub 2012 Jan 9.


Platelet-derived growth factor C promotes revascularization in ischemic limbs of diabetic mice.

Moriya J, Wu X, Zavala-Solorio J, Ross J, Liang XH, Ferrara N.

J Vasc Surg. 2014 May;59(5):1402-9.e1-4. doi: 10.1016/j.jvs.2013.04.053. Epub 2013 Jul 13.


Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis.

Martin IV, Borkham-Kamphorst E, Zok S, van Roeyen CR, Eriksson U, Boor P, Hittatiya K, Fischer HP, Wasmuth HE, Weiskirchen R, Eitner F, Floege J, Ostendorf T.

Am J Pathol. 2013 Jan;182(1):107-17. doi: 10.1016/j.ajpath.2012.09.006. Epub 2012 Nov 7.


Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.

Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, Zhang Y, Zhang SZ, Ding H, Fariss RN, Becker KG, Lennartsson J, Nagai N, Cao Y, Li X.

J Exp Med. 2010 Apr 12;207(4):867-80. doi: 10.1084/jem.20091704. Epub 2010 Mar 15.


A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.

Ding H, Wu X, Boström H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY, Soriano P, Betsholtz C, Hart TC, Marazita ML, Field LL, Tam PP, Nagy A.

Nat Genet. 2004 Oct;36(10):1111-6. Epub 2004 Sep 7.


PDGF-D is a potent transforming and angiogenic growth factor.

Li H, Fredriksson L, Li X, Eriksson U.

Oncogene. 2003 Mar 13;22(10):1501-10.


PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.

Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA.

Arterioscler Thromb Vasc Biol. 2004 Apr;24(4):787-92.


Generation of conditional knockout alleles for PDGF-C.

Wu X, Ding H.

Genesis. 2007 Oct;45(10):653-7.


Oligodendrocyte progenitor cells promote neovascularization in glioma by disrupting the blood-brain barrier.

Huang Y, Hoffman C, Rajappa P, Kim JH, Hu W, Huse J, Tang Z, Li X, Weksler B, Bromberg J, Lyden DC, Greenfield JP.

Cancer Res. 2014 Feb 15;74(4):1011-21. doi: 10.1158/0008-5472.CAN-13-1072. Epub 2013 Dec 26.


Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice.

Basciani S, Mariani S, Arizzi M, Brama M, Ricci A, Betsholtz C, Bondjers C, Ricci G, Catizone A, Galdieri M, Spera G, Gnessi L.

Biol Reprod. 2004 Jan;70(1):168-77. Epub 2003 Oct 1.


PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.

Thomas JA, Deaton RA, Hastings NE, Shang Y, Moehle CW, Eriksson U, Topouzis S, Wamhoff BR, Blackman BR, Owens GK.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H442-52. doi: 10.1152/ajpheart.00165.2008. Epub 2008 Nov 21.


Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart.

Chong JJ, Reinecke H, Iwata M, Torok-Storb B, Stempien-Otero A, Murry CE.

Stem Cells Dev. 2013 Jul 1;22(13):1932-43. doi: 10.1089/scd.2012.0542. Epub 2013 Mar 26.


Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.

Gilbertson DG, Duff ME, West JW, Kelly JD, Sheppard PO, Hofstrand PD, Gao Z, Shoemaker K, Bukowski TR, Moore M, Feldhaus AL, Humes JM, Palmer TE, Hart CE.

J Biol Chem. 2001 Jul 20;276(29):27406-14. Epub 2001 Apr 10.


PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.

Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Törnell J, Heath JK, Betsholtz C.

Cell. 1996 Jun 14;85(6):863-73.


VEGF is major stimulator in model of choroidal neovascularization.

Kwak N, Okamoto N, Wood JM, Campochiaro PA.

Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3158-64.


Role of platelet-derived growth factor-α in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps.

Lin H, Lin D, Xiong XS, Dai XX, Lin T.

Int Forum Allergy Rhinol. 2014 Nov;4(11):909-14. doi: 10.1002/alr.21419. Epub 2014 Sep 25.


Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice.

Pontén A, Folestad EB, Pietras K, Eriksson U.

Circ Res. 2005 Nov 11;97(10):1036-45. Epub 2005 Oct 13.

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