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Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal SR, Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B.

Cell. 2012 Jan 20;148(1-2):259-72. doi: 10.1016/j.cell.2011.11.050. Epub 2012 Jan 5. Erratum in: Cell. 2012 Mar 2;148(5):1066. Mitchell, Wayne [added].


Glycine decarboxylase and HIF-1α expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer.

Berezowska S, Galván JA, Langer R, Bubendorf L, Savic S, Gugger M, Schmid RA, Marti TM.

Virchows Arch. 2017 Mar;470(3):323-330. doi: 10.1007/s00428-016-2057-z. Epub 2017 Jan 7.


Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis.

Go MK, Zhang WC, Lim B, Yew WS.

Biochemistry. 2014 Feb 11;53(5):947-56. doi: 10.1021/bi4014227. Epub 2014 Feb 3.


Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation.

Winn RA, Marek L, Han SY, Rodriguez K, Rodriguez N, Hammond M, Van Scoyk M, Acosta H, Mirus J, Barry N, Bren-Mattison Y, Van Raay TJ, Nemenoff RA, Heasley LE.

J Biol Chem. 2005 May 20;280(20):19625-34. Epub 2005 Feb 10.


Expression in human lung cancer cell lines of genes of prohormone processing and the neuroendocrine phenotype.

Vos MD, Scott FM, Iwai N, Treston AM.

J Cell Biochem Suppl. 1996;24:257-68.


Glycine Decarboxylase Expression Increased in p53-Mutated B Cell Lymphoma Mice.

Li X, Cui C, Guo Y, Yang G.

Oncol Res Treat. 2015;38(11):586-9. doi: 10.1159/000441595. Epub 2015 Oct 23.


IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells.

Chang KT, Tsai CM, Chiou YC, Chiu CH, Jeng KS, Huang CY.

Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L446-53. Epub 2005 May 13.


C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers.

Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L.

Clin Cancer Res. 2000 Aug;6(8):2988-93.


The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.

Mao X, Seidlitz E, Ghosh K, Murakami Y, Ghosh HP.

Cancer Res. 2003 Nov 15;63(22):7979-85.


Predictive factors in radiotherapy for non-small cell lung cancer: present status.

Choi N, Baumann M, Flentjie M, Kellokumpu-Lehtinen P, Senan S, Zamboglou N, Kosmidis P.

Lung Cancer. 2001 Jan;31(1):43-56. Review.


A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.

Tsai MF, Wang CC, Chang GC, Chen CY, Chen HY, Cheng CL, Yang YP, Wu CY, Shih FY, Liu CC, Lin HP, Jou YS, Lin SC, Lin CW, Chen WJ, Chan WK, Chen JJ, Yang PC.

J Natl Cancer Inst. 2006 Jun 21;98(12):825-38.


Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation.

Paleari L, Catassi A, Ciarlo M, Cavalieri Z, Bruzzo C, Servent D, Cesario A, Chessa L, Cilli M, Piccardi F, Granone P, Russo P.

Cell Prolif. 2008 Dec;41(6):936-59. doi: 10.1111/j.1365-2184.2008.00566.x. Erratum in: Cell Prolif. 2009 Feb;42(1):122. Cell Prolif. 2009 Aug;42(4):568.


C10ORF97 is a novel tumor-suppressor gene of non-small-cell lung cancer and a functional variant of this gene increases the risk of non-small-cell lung cancer.

Shi Y, Chen J, Li Z, Zhang Z, Yu H, Sun K, Wang X, Song X, Wang Y, Zhen Y, Yang T, Lou K, Zhang Y, Zhang G, Hu Y, Ji J, Hui R.

Oncogene. 2011 Sep 29;30(39):4107-17. doi: 10.1038/onc.2011.116. Epub 2011 Apr 18.


Constitutive activation of met kinase in non-small-cell lung carcinomas correlates with anchorage-independent cell survival.

Qiao H, Hung W, Tremblay E, Wojcik J, Gui J, Ho J, Klassen J, Campling B, Elliott B.

J Cell Biochem. 2002;86(4):665-77.


Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.

Nguyen MH, Koinuma J, Ueda K, Ito T, Tsuchiya E, Nakamura Y, Daigo Y.

Cancer Res. 2010 Jul 1;70(13):5337-47. doi: 10.1158/0008-5472.CAN-09-4372. Epub 2010 Jun 15.


Overexpression of Pokemon in non-small cell lung cancer and foreshowing tumor biological behavior as well as clinical results.

Zhao ZH, Wang SF, Yu L, Wang J, Chang H, Yan WL, Zhang J, Fu K.

Lung Cancer. 2008 Oct;62(1):113-9. doi: 10.1016/j.lungcan.2008.02.014. Epub 2008 Jun 11.


SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM.

Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8.


The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation.

Kanou T, Oneyama C, Kawahara K, Okimura A, Ohta M, Ikeda N, Shintani Y, Okumura M, Okada M.

Mol Cancer Res. 2011 Jan;9(1):103-14. doi: 10.1158/1541-7786.MCR-10-0340. Epub 2010 Dec 14.


Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.

Yuan BZ, Jefferson AM, Millecchia L, Popescu NC, Reynolds SH.

Exp Cell Res. 2007 Nov 1;313(18):3868-80. Epub 2007 Aug 21.


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