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Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis.

Feng Z, Chakraborty D, Dewell SB, Reddy BV, Brady SF.

J Am Chem Soc. 2012 Feb 15;134(6):2981-7. doi: 10.1021/ja207662w. Epub 2012 Feb 2.


Synthesis and biological evaluation of platensimycin analogs.

Shen HC, Ding FX, Singh SB, Parthasarathy G, Soisson SM, Ha SN, Chen X, Kodali S, Wang J, Dorso K, Tata JR, Hammond ML, Maccoss M, Colletti SL.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1623-7. doi: 10.1016/j.bmcl.2009.02.006. Epub 2009 Feb 7.


Platensimycin is a selective FabF inhibitor with potent antibiotic properties.

Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB.

Nature. 2006 May 18;441(7091):358-61.


FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Parsons JB, Yao J, Frank MW, Rock CO.

Antimicrob Agents Chemother. 2015 Feb;59(2):849-58. doi: 10.1128/AAC.04179-14. Epub 2014 Nov 17.


Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB.

Proc Natl Acad Sci U S A. 2007 May 1;104(18):7612-6. Epub 2007 Apr 24.


Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form.

Baum B, Lecker LS, Zoltner M, Jaenicke E, Schnell R, Hunter WN, Brenk R.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1020-6. doi: 10.1107/S2053230X15010614. Epub 2015 Jul 28.


Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters.

Kallifidas D, Kang HS, Brady SF.

J Am Chem Soc. 2012 Dec 5;134(48):19552-5. doi: 10.1021/ja3093828. Epub 2012 Nov 27.


Response of Bacillus subtilis to cerulenin and acquisition of resistance.

Schujman GE, Choi KH, Altabe S, Rock CO, de Mendoza D.

J Bacteriol. 2001 May;183(10):3032-40.


Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites.

Feng Z, Kallifidas D, Brady SF.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12629-34. doi: 10.1073/pnas.1103921108. Epub 2011 Jul 18.


Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB.

Schaeffer ML, Agnihotri G, Volker C, Kallender H, Brennan PJ, Lonsdale JT.

J Biol Chem. 2001 Dec 14;276(50):47029-37. Epub 2001 Oct 12.


Screening of flavonoids as candidate antibiotics against Enterococcus faecalis.

Jeong KW, Lee JY, Kang DI, Lee JU, Shin SY, Kim Y.

J Nat Prod. 2009 Apr;72(4):719-24. doi: 10.1021/np800698d.


Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics.

Lee JY, Jeong KW, Lee JU, Kang DI, Kim Y.

Bioorg Med Chem. 2009 Feb 15;17(4):1506-13. doi: 10.1016/j.bmc.2009.01.004. Epub 2009 Jan 11.


Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.

Hasman H, Aarestrup FM, Dalsgaard A, Guardabassi L.

J Antimicrob Chemother. 2006 Apr;57(4):648-53. Epub 2006 Feb 13.


Discovery of FabH/FabF inhibitors from natural products.

Young K, Jayasuriya H, Ondeyka JG, Herath K, Zhang C, Kodali S, Galgoci A, Painter R, Brown-Driver V, Yamamoto R, Silver LL, Zheng Y, Ventura JI, Sigmund J, Ha S, Basilio A, Vicente F, Tormo JR, Pelaez F, Youngman P, Cully D, Barrett JF, Schmatz D, Singh SB, Wang J.

Antimicrob Agents Chemother. 2006 Feb;50(2):519-26.


Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis.

Zhu L, Cheng J, Luo B, Feng S, Lin J, Wang S, Cronan JE, Wang H.

BMC Microbiol. 2009 Jun 4;9:119. doi: 10.1186/1471-2180-9-119.


Environmental fatty acids enable emergence of infectious Staphylococcus aureus resistant to FASII-targeted antimicrobials.

Morvan C, Halpern D, Kénanian G, Hays C, Anba-Mondoloni J, Brinster S, Kennedy S, Trieu-Cuot P, Poyart C, Lamberet G, Gloux K, Gruss A.

Nat Commun. 2016 Oct 5;7:12944. doi: 10.1038/ncomms12944.


A malonyl-CoA-dependent switch in the bacterial response to a dysfunction of lipid metabolism.

Schujman GE, Altabe S, de Mendoza D.

Mol Microbiol. 2008 May;68(4):987-96. doi: 10.1111/j.1365-2958.2008.06202.x. Epub 2008 Apr 2.

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