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Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection.

Whitemarsh RC, Strathman MJ, Chase LG, Stankewicz C, Tepp WH, Johnson EA, Pellett S.

Toxicol Sci. 2012 Apr;126(2):426-35. doi: 10.1093/toxsci/kfr354.


Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells.

Pellett S, Du ZW, Pier CL, Tepp WH, Zhang SC, Johnson EA.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):388-92. doi: 10.1016/j.bbrc.2010.11.128.


Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research.

McNutt P, Celver J, Hamilton T, Mesngon M.

Biochem Biophys Res Commun. 2011 Feb 4;405(1):85-90. doi: 10.1016/j.bbrc.2010.12.132.


Analysis of gene expression in induced pluripotent stem cell-derived human neurons exposed to botulinum neurotoxin A subtype 1 and a type A atoxic derivative.

Scherf JM, Hu XS, Tepp WH, Ichtchenko K, Johnson EA, Pellett S.

PLoS One. 2014 Oct 22;9(10):e111238. doi: 10.1371/journal.pone.0111238.


Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin.

Pellett S, Schwartz MP, Tepp WH, Josephson R, Scherf JM, Pier CL, Thomson JA, Murphy WL, Johnson EA.

Sci Rep. 2015 Sep 28;5:14566. doi: 10.1038/srep14566.


Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination.

Pellett S, Tepp WH, Toth SI, Johnson EA.

J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):304-10. doi: 10.1016/j.vascn.2010.01.003.


Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle Recycling.

Pellett S, Tepp WH, Scherf JM, Johnson EA.

PLoS One. 2015 Jul 24;10(7):e0133737. doi: 10.1371/journal.pone.0133737.


Activity of botulinum neurotoxin type D (strain 1873) in human neurons.

Pellett S, Tepp WH, Scherf JM, Pier CL, Johnson EA.

Toxicon. 2015 Jul;101:63-9. doi: 10.1016/j.toxicon.2015.04.015.


A microscale neuron and Schwann cell coculture model for increasing detection sensitivity of botulinum neurotoxin type A.

Hong WS, Young EW, Tepp WH, Johnson EA, Beebe DJ.

Toxicol Sci. 2013 Jul;134(1):64-72. doi: 10.1093/toxsci/kft082.


A rapid chemiluminescent slot blot immunoassay for the detection and quantification of Clostridium botulinum neurotoxin type E, in cultures.

Cadieux B, Blanchfield B, Smith JP, Austin JW.

Int J Food Microbiol. 2005 May 1;101(1):9-16.


Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons.

Mesngon M, McNutt P.

Toxins (Basel). 2011 May;3(5):489-503. doi: 10.3390/toxins3050489.


High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.

Hubbard KS, Gut IM, Lyman ME, Tuznik KM, Mesngon MT, McNutt PM.

BMC Neurosci. 2012 Oct 24;13:127. doi: 10.1186/1471-2202-13-127.


Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S.

PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264.


Persistence of botulinum neurotoxin A demonstrated by sequential administration of serotypes A and E in rat EDL muscle.

Adler M, Keller JE, Sheridan RE, Deshpande SS.

Toxicon. 2001 Feb-Mar;39(2-3):233-43.


Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.

Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S.

Toxins (Basel). 2011 Mar;3(3):207-17. doi: 10.3390/toxins3030207.


Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.

Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong M.

J Cell Sci. 2012 Jul 1;125(Pt 13):3233-42. doi: 10.1242/jcs.103564.


Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.

Beske PH, Scheeler SM, Adler M, McNutt PM.

Front Cell Neurosci. 2015 Apr 23;9:159. doi: 10.3389/fncel.2015.00159.


Purification and Characterization of Botulinum Neurotoxin FA from a Genetically Modified Clostridium botulinum Strain.

Pellett S, Tepp WH, Bradshaw M, Kalb SR, Dykes JK, Lin G, Nawrocki EM, Pier CL, Barr JR, Maslanka SE, Johnson EA.

mSphere. 2016 Feb 24;1(1). pii: e00100-15. doi: 10.1128/mSphere.00100-15.


A neuronal cell-based botulinum neurotoxin assay for highly sensitive and specific detection of neutralizing serum antibodies.

Pellett S, Tepp WH, Clancy CM, Borodic GE, Johnson EA.

FEBS Lett. 2007 Oct 16;581(25):4803-8.

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