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Items: 1 to 20 of 78

1.

Modeling of bias for the analysis of receptor signaling in biochemical systems.

Barak LS, Peterson S.

Biochemistry. 2012 Feb 14;51(6):1114-25. doi: 10.1021/bi201308s. Epub 2012 Feb 2.

2.

Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.

Peterson SM, Pack TF, Caron MG.

PLoS One. 2015 Oct 30;10(10):e0141637. doi: 10.1371/journal.pone.0141637. eCollection 2015.

3.

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.

Peterson SM, Pack TF, Wilkins AD, Urs NM, Urban DJ, Bass CE, Lichtarge O, Caron MG.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7097-102. doi: 10.1073/pnas.1502742112. Epub 2015 May 11.

4.

Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguish β-arrestin-mediated from G protein-mediated signaling.

Emery AC, DiRaddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT.

Mol Pharmacol. 2012 Aug;82(2):291-301. doi: 10.1124/mol.112.078444. Epub 2012 May 14.

5.

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.

Allen JA, Yost JM, Setola V, Chen X, Sassano MF, Chen M, Peterson S, Yadav PN, Huang XP, Feng B, Jensen NH, Che X, Bai X, Frye SV, Wetsel WC, Caron MG, Javitch JA, Roth BL, Jin J.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. doi: 10.1073/pnas.1104807108. Epub 2011 Oct 24.

6.

Biased ligand modulation of seven transmembrane receptors (7TMRs): functional implications for drug discovery.

Correll CC, McKittrick BA.

J Med Chem. 2014 Aug 28;57(16):6887-96. doi: 10.1021/jm401677g. Epub 2014 Apr 29.

PMID:
24697360
7.

Biased signaling through G-protein-coupled PROKR2 receptors harboring missense mutations.

Sbai O, Monnier C, Dodé C, Pin JP, Hardelin JP, Rondard P.

FASEB J. 2014 Aug;28(8):3734-44. doi: 10.1096/fj.13-243402. Epub 2014 May 15.

PMID:
24830383
8.

Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.

Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22.

9.

Beta-arrestin-biased ligands at seven-transmembrane receptors.

Violin JD, Lefkowitz RJ.

Trends Pharmacol Sci. 2007 Aug;28(8):416-22. Epub 2007 Jul 20. Review.

PMID:
17644195
10.

Analysis of functional selectivity through G protein-dependent and -independent signaling pathways at the adrenergic α(2C) receptor.

Kurko D, Kapui Z, Nagy J, Lendvai B, Kolok S.

Brain Res Bull. 2014 Aug;107:89-101. doi: 10.1016/j.brainresbull.2014.07.005. Epub 2014 Jul 29.

PMID:
25080296
11.

Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.

Min C, Zheng M, Zhang X, Caron MG, Kim KM.

Br J Pharmacol. 2013 Nov;170(5):1112-29. doi: 10.1111/bph.12357.

12.

Decoding dopamine signaling.

Bibb JA.

Cell. 2005 Jul 29;122(2):153-5.

13.

Functional selectivity and classical concepts of quantitative pharmacology.

Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB.

J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. Epub 2006 Jun 27. Review.

14.

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9988-93. doi: 10.1073/pnas.0804246105. Epub 2008 Jul 11.

15.

Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.

Masri B, Salahpour A, Didriksen M, Ghisi V, Beaulieu JM, Gainetdinov RR, Caron MG.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13656-61. doi: 10.1073/pnas.0803522105. Epub 2008 Sep 3.

16.

Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors.

Brulé C, Perzo N, Joubert JE, Sainsily X, Leduc R, Castel H, Prézeau L.

FASEB J. 2014 Dec;28(12):5148-62. doi: 10.1096/fj.14-249771. Epub 2014 Sep 2.

PMID:
25183668
17.

Heptahelical terpsichory. Who calls the tune?

Gesty-Palmer D, Luttrell LM.

J Recept Signal Transduct Res. 2008;28(1-2):39-58. doi: 10.1080/10799890801941921 . Review.

PMID:
18437629
18.

beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.

Rakesh K, Yoo B, Kim IM, Salazar N, Kim KS, Rockman HA.

Sci Signal. 2010 Jun 8;3(125):ra46. doi: 10.1126/scisignal.2000769.

19.

Seven-transmembrane receptor signaling through beta-arrestin.

Shenoy SK, Lefkowitz RJ.

Sci STKE. 2005 Nov 1;2005(308):cm10. Review.

20.

β-arrestin-mediated signaling improves the efficacy of therapeutics.

Ibrahim IA, Kurose H.

J Pharmacol Sci. 2012;118(4):408-12. Epub 2012 Mar 23. Review.

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