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Items: 1 to 20 of 122

1.

Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium.

Usatyuk PV, Singleton PA, Pendyala S, Kalari SK, He D, Gorshkova IA, Camp SM, Moitra J, Dudek SM, Garcia JG, Natarajan V.

J Biol Chem. 2012 Mar 16;287(12):9360-75. doi: 10.1074/jbc.M111.294546. Epub 2012 Jan 4.

2.

Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium.

Singleton PA, Pendyala S, Gorshkova IA, Mambetsariev N, Moitra J, Garcia JG, Natarajan V.

J Biol Chem. 2009 Dec 11;284(50):34964-75. doi: 10.1074/jbc.M109.013771. Epub 2009 Oct 15.

3.

Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin.

Usatyuk PV, Romer LH, He D, Parinandi NL, Kleinberg ME, Zhan S, Jacobson JR, Dudek SM, Pendyala S, Garcia JG, Natarajan V.

J Biol Chem. 2007 Aug 10;282(32):23284-95. Epub 2007 Jun 11.

4.

Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells.

Usatyuk PV, Gorshkova IA, He D, Zhao Y, Kalari SK, Garcia JG, Natarajan V.

J Biol Chem. 2009 May 29;284(22):15339-52. doi: 10.1074/jbc.M109.005439. Epub 2009 Apr 14.

5.

Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells.

Chowdhury AK, Watkins T, Parinandi NL, Saatian B, Kleinberg ME, Usatyuk PV, Natarajan V.

J Biol Chem. 2005 May 27;280(21):20700-11. Epub 2005 Mar 17.

6.

Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium.

Brown M, Adyshev D, Bindokas V, Moitra J, Garcia JG, Dudek SM.

Microvasc Res. 2010 Jul;80(1):75-88. doi: 10.1016/j.mvr.2009.12.010. Epub 2010 Jan 4.

7.

Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics.

Belvitch P, Adyshev D, Elangovan VR, Brown ME, Naureckas C, Rizzo AN, Siegler JH, Garcia JG, Dudek SM.

Microvasc Res. 2014 Sep;95:94-102. doi: 10.1016/j.mvr.2014.07.007. Epub 2014 Jul 27.

8.

Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments.

Patel VB, Wang Z, Fan D, Zhabyeyev P, Basu R, Das SK, Wang W, Desaulniers J, Holland SM, Kassiri Z, Oudit GY.

Circ Res. 2013 Jun 7;112(12):1542-56. doi: 10.1161/CIRCRESAHA.111.300299. Epub 2013 Apr 3.

9.

Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.

Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier JL, Garcia JG, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2003 Jan;284(1):L26-38. Epub 2002 Jul 26.

10.

Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

Dudek SM, Chiang ET, Camp SM, Guo Y, Zhao J, Brown ME, Singleton PA, Wang L, Desai A, Arce FT, Lal R, Van Eyk JE, Imam SZ, Garcia JG.

Mol Biol Cell. 2010 Nov 15;21(22):4042-56. doi: 10.1091/mbc.E09-10-0876. Epub 2010 Sep 22.

11.

Activation of endothelial cells after exposure to ambient ultrafine particles: the role of NADPH oxidase.

Mo Y, Wan R, Chien S, Tollerud DJ, Zhang Q.

Toxicol Appl Pharmacol. 2009 Apr 15;236(2):183-93. doi: 10.1016/j.taap.2009.01.017. Epub 2009 Feb 5.

PMID:
19371610
12.

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter.

Pendyala S, Moitra J, Kalari S, Kleeberger SR, Zhao Y, Reddy SP, Garcia JG, Natarajan V.

Free Radic Biol Med. 2011 Jun 15;50(12):1749-59. doi: 10.1016/j.freeradbiomed.2011.03.022. Epub 2011 Mar 26.

13.

NADPH oxidase in bone marrow-derived cells mediates pulmonary ischemia-reperfusion injury.

Yang Z, Sharma AK, Marshall M, Kron IL, Laubach VE.

Am J Respir Cell Mol Biol. 2009 Mar;40(3):375-81. doi: 10.1165/rcmb.2008-0300OC. Epub 2008 Sep 11.

14.

Bioluminescence imaging of NADPH oxidase activity in different animal models.

Han W, Li H, Segal BH, Blackwell TS.

J Vis Exp. 2012 Oct 22;(68). pii: 3925. doi: 10.3791/3925.

15.

NADPH oxidase modulates myocardial Akt, ERK1/2 activation, and angiogenesis after hypoxia-reoxygenation.

Chen JX, Zeng H, Tuo QH, Yu H, Meyrick B, Aschner JL.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1664-74. Epub 2007 Jan 12.

16.

Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells.

Pendyala S, Gorshkova IA, Usatyuk PV, He D, Pennathur A, Lambeth JD, Thannickal VJ, Natarajan V.

Antioxid Redox Signal. 2009 Apr;11(4):747-64. doi: 10.1089/ARS.2008.2203.

17.

Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src).

Garcia JG, Verin AD, Schaphorst K, Siddiqui R, Patterson CE, Csortos C, Natarajan V.

Am J Physiol. 1999 Jun;276(6 Pt 1):L989-98.

18.

Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.

Feng J, Damrauer SM, Lee M, Sellke FW, Ferran C, Abid MR.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1703-10. doi: 10.1161/ATVBAHA.110.209726. Epub 2010 Aug 11.

19.

Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.

Pendyala S, Usatyuk PV, Gorshkova IA, Garcia JG, Natarajan V.

Antioxid Redox Signal. 2009 Apr;11(4):841-60. doi: 10.1089/ARS.2008.2231. Review.

20.

Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit.

Li JM, Shah AM.

J Biol Chem. 2003 Apr 4;278(14):12094-100. Epub 2003 Jan 30.

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