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Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage.

Fitzgerald DP, Subramanian P, Deshpande M, Graves C, Gordon I, Qian Y, Snitkovsky Y, Liewehr DJ, Steinberg SM, Paltán-Ortiz JD, Herman MM, Camphausen K, Palmieri D, Becerra SP, Steeg PS.

Cancer Res. 2012 Jan 1;72(1):144-53. doi: 10.1158/0008-5472.CAN-11-1904.


Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment.

Halin S, Rudolfsson SH, Doll JA, Crawford SE, Wikström P, Bergh A.

Neoplasia. 2010 Apr;12(4):336-45.


Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin.

Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, Li C, Li S, Li L, Zhang T, Qi W, Bardeesi AS, Yang Z, Cai W, Yang X, Gao G.

Breast Cancer Res Treat. 2014 Nov;148(1):61-72. doi: 10.1007/s10549-014-3154-9. Epub 2014 Oct 5.


Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn.

Kanda S, Mochizuki Y, Nakamura T, Miyata Y, Matsuyama T, Kanetake H.

J Cell Sci. 2005 Mar 1;118(Pt 5):961-70. Epub 2005 Feb 15.


Vacuolar H+-ATPase is down-regulated by the angiogenesis-inhibitory pigment epithelium-derived factor in metastatic prostate cancer cells.

Sennoune SR, Bermudez LE, Lees JC, Hirsch J, Filleur S, Martínez-Zaguilán R.

Cell Mol Biol (Noisy-le-grand). 2014 May 25;60(1):45-52.


Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation.

Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, Hong HH, Qi WW, Zhou T, Li CY, Yang X, Gao GQ.

J Biol Chem. 2014 Oct 31;289(44):30785-99. doi: 10.1074/jbc.M114.590000. Epub 2014 Sep 15.


Loss of pigment epithelium-derived factor: a novel mechanism for the development of endocrine resistance in breast cancer.

Jan R, Huang M, Lewis-Wambi J.

Breast Cancer Res. 2012 Nov 14;14(6):R146. doi: 10.1186/bcr3356.


Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma.

Lattier JM, Yang H, Crawford S, Grossniklaus HE.

Clin Exp Metastasis. 2013 Dec;30(8):969-76. doi: 10.1007/s10585-013-9596-3. Epub 2013 Jun 22.


Pigment epithelium-derived factor and interleukin-6 control prostate neuroendocrine differentiation via feed-forward mechanism.

Smith ND, Schulze-Hoepfner FT, Veliceasa D, Filleur S, Shareef S, Huang L, Huang XM, Volpert OV.

J Urol. 2008 Jun;179(6):2427-34. doi: 10.1016/j.juro.2008.01.081. Epub 2008 Apr 23.


In vitro and in vivo biological activity of PEDF against a range of tumors.

Broadhead ML, Dass CR, Choong PF.

Expert Opin Ther Targets. 2009 Dec;13(12):1429-38. doi: 10.1517/14728220903307475. Review.


Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice.

Hase R, Miyamoto M, Uehara H, Kadoya M, Ebihara Y, Murakami Y, Takahashi R, Mega S, Li L, Shichinohe T, Kawarada Y, Kondo S.

Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8737-44.


Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis.

Yang J, Chen S, Huang X, Han J, Wang Q, Shi D, Cheng R, Gao G, Yang X.

Cancer Biol Ther. 2010 Jun 15;9(12):967-74. Epub 2010 Jun 8.


Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor.

Abramson LP, Browne M, Stellmach V, Doll J, Cornwell M, Reynolds M, Arensman RM, Crawford SE.

J Pediatr Surg. 2006 Aug;41(8):1351-6.


Adeno-associated virus vector-mediated delivery of pigment epithelium-derived factor restricts neuroblastoma angiogenesis and growth.

Streck CJ, Zhang Y, Zhou J, Ng C, Nathwani AC, Davidoff AM.

J Pediatr Surg. 2005 Jan;40(1):236-43.


Synergistic antitumor effect of recombinant adeno-associated virus-mediated pigment epithelium-derived factor with hyperthermia on solid tumor.

Wu Q, He S, Wei X, Shao B, Luo S, Guo F, Zhang H, Wang Y, Gong C, Yang L.

Hum Gene Ther. 2014 Sep;25(9):811-23. doi: 10.1089/hum.2013.150. Epub 2014 Aug 21.


Pigment epithelium-derived factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome proliferator-activated receptor gamma.

Ho TC, Yang YC, Chen SL, Kuo PC, Sytwu HK, Cheng HC, Tsao YP.

Mol Immunol. 2008 Feb;45(4):898-909. Epub 2007 Sep 17.


Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis.

Ek ET, Dass CR, Contreras KG, Choong PF.

Cancer Gene Ther. 2007 Jul;14(7):616-26. Epub 2007 May 4.


Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor.

Garcia M, Fernandez-Garcia NI, Rivas V, Carretero M, Escamez MJ, Gonzalez-Martin A, Medrano EE, Volpert O, Jorcano JL, Jimenez B, Larcher F, Del Rio M.

Cancer Res. 2004 Aug 15;64(16):5632-42.


Pigment epithelium-derived factor regulates early pancreatic fibrotic responses and suppresses the profibrotic cytokine thrombospondin-1.

Schmitz JC, Protiva P, Gattu AK, Utsumi T, Iwakiri Y, Neto AG, Quinn M, Cornwell ML, Fitchev P, Lugea A, Crawford SE, Chung C.

Am J Pathol. 2011 Dec;179(6):2990-9. doi: 10.1016/j.ajpath.2011.08.009. Epub 2011 Sep 28.

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