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Items: 1 to 20 of 128

1.

Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.

Lang VY, Fatehi M, Light PE.

Pharmacogenet Genomics. 2012 Mar;22(3):206-14. doi: 10.1097/FPC.0b013e32835001e7.

PMID:
22209866
2.

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

Diabetes. 2009 Oct;58(10):2419-24. doi: 10.2337/db09-0143. Epub 2009 Jul 8.

3.

The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity.

Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light PE.

Diabetes. 2012 Jan;61(1):241-9. doi: 10.2337/db11-0371.

4.

The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.

Sunaga Y, Gonoi T, Shibasaki T, Ichikawa K, Kusama H, Yano H, Seino S.

Eur J Pharmacol. 2001 Nov 9;431(1):119-25.

PMID:
11716850
5.

Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide.

Hu S, Wang S, Fanelli B, Bell PA, Dunning BE, Geisse S, Schmitz R, Boettcher BR.

J Pharmacol Exp Ther. 2000 May;293(2):444-52.

6.

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2004 May;53(5):1360-8.

7.

Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.

Lim JG, Lee HY, Yun JE, Kim SP, Park JW, Suh SI, Jang BC, Cho CH, Bae JH, Kim SS, Han J, Park MJ, Song DK.

Biochem Pharmacol. 2004 Sep 1;68(5):901-10.

PMID:
15294453
8.

ABCC8 polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas.

Sato R, Watanabe H, Genma R, Takeuchi M, Maekawa M, Nakamura H.

Pharmacogenomics. 2010 Dec;11(12):1743-50. doi: 10.2217/pgs.10.135.

PMID:
21142918
9.

Variations in tissue selectivity amongst insulin secretagogues: a systematic review.

Abdelmoneim AS, Hasenbank SE, Seubert JM, Brocks DR, Light PE, Simpson SH.

Diabetes Obes Metab. 2012 Feb;14(2):130-8. doi: 10.1111/j.1463-1326.2011.01496.x. Epub 2011 Nov 3. Review.

PMID:
21923736
10.

Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes.

Chistiakov DA, Potapov VA, Khodirev DC, Shamkhalova MS, Shestakova MV, Nosikov VV.

Acta Diabetol. 2009 Mar;46(1):43-9. doi: 10.1007/s00592-008-0056-5. Epub 2008 Aug 29.

PMID:
18758683
12.

Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure.

Dörschner H, Brekardin E, Uhde I, Schwanstecher C, Schwanstecher M.

Mol Pharmacol. 1999 Jun;55(6):1060-6.

13.

Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.

Babenko AP, Polak M, Cavé H, Busiah K, Czernichow P, Scharfmann R, Bryan J, Aguilar-Bryan L, Vaxillaire M, Froguel P.

N Engl J Med. 2006 Aug 3;355(5):456-66.

14.

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2003 Feb;52(2):568-72.

15.

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

Vedovato N, Cliff E, Proks P, Poovazhagi V, Flanagan SE, Ellard S, Hattersley AT, Ashcroft FM.

Diabetologia. 2016 Jul;59(7):1430-1436. doi: 10.1007/s00125-016-3964-x. Epub 2016 Apr 27.

16.

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population.

Sakamoto Y, Inoue H, Keshavarz P, Miyawaki K, Yamaguchi Y, Moritani M, Kunika K, Nakamura N, Yoshikawa T, Yasui N, Shiota H, Tanahashi T, Itakura M.

J Hum Genet. 2007;52(10):781-93. Epub 2007 Sep 6.

PMID:
17823772
17.

Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A + B-site ligands.

Winkler M, Stephan D, Bieger S, Kühner P, Wolff F, Quast U.

J Pharmacol Exp Ther. 2007 Aug;322(2):701-8. Epub 2007 May 10.

18.

Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.

Babenko AP, Gonzalez G, Aguilar-Bryan L, Bryan J.

Circ Res. 1998 Nov 30;83(11):1132-43.

PMID:
9831708
19.

Altered functional properties of KATP channel conferred by a novel splice variant of SUR1.

Sakura H, Trapp S, Liss B, Ashcroft FM.

J Physiol. 1999 Dec 1;521 Pt 2:337-50.

20.

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT; Neonatal Diabetes International Collaborative Group.

N Engl J Med. 2006 Aug 3;355(5):467-77.

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