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Items: 1 to 20 of 87

1.

The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.

Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA.

Mol Endocrinol. 2012 Feb;26(2):341-8. doi: 10.1210/me.2011-1149. Epub 2011 Dec 29.

2.

Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.

Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA.

Endocrinology. 2008 Jan;149(1):146-53. Epub 2007 Oct 11.

3.

Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency.

Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA.

Bone. 2014 Sep;66:146-54. doi: 10.1016/j.bone.2014.06.006. Epub 2014 Jun 14.

4.
5.

IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.

O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E784-93. Epub 2005 Jun 14.

PMID:
15956054
6.

Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL.

Onal M, St John HC, Danielson AL, Markert JW, Riley EM, Pike JW.

Endocrinology. 2016 Feb;157(2):482-96. doi: 10.1210/en.2015-1788. Epub 2015 Dec 8.

7.

Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes.

Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T.

Endocrinology. 2014 Aug;155(8):2797-809. doi: 10.1210/en.2014-1046. Epub 2014 May 30.

8.

IL-1 plays an important role in the bone metabolism under physiological conditions.

Lee YM, Fujikado N, Manaka H, Yasuda H, Iwakura Y.

Int Immunol. 2010 Oct;22(10):805-16. doi: 10.1093/intimm/dxq431. Epub 2010 Aug 2.

PMID:
20679512
9.

Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice.

Piemontese M, Xiong J, Fujiwara Y, Thostenson JD, O'Brien CA.

Am J Physiol Endocrinol Metab. 2016 Sep 1;311(3):E587-93. doi: 10.1152/ajpendo.00219.2016. Epub 2016 Jul 26.

10.

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment.

Arai A, Mizoguchi T, Harada S, Kobayashi Y, Nakamichi Y, Yasuda H, Penninger JM, Yamada K, Udagawa N, Takahashi N.

J Cell Sci. 2012 Jun 15;125(Pt 12):2910-7. doi: 10.1242/jcs.099986. Epub 2012 Mar 27.

11.

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice.

Fujiwara Y, Piemontese M, Liu Y, Thostenson JD, Xiong J, O'Brien CA.

J Biol Chem. 2016 Nov 25;291(48):24838-24850. Epub 2016 Oct 12.

12.

Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice.

Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH.

Biochem Pharmacol. 2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6.

PMID:
23928189
13.

Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss.

Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA.

J Biol Chem. 2012 Aug 24;287(35):29851-60. doi: 10.1074/jbc.M112.377945. Epub 2012 Jul 10.

14.

OPG Treatment Prevents Bone Loss During Lactation But Does Not Affect Milk Production or Maternal Calcium Metabolism.

Ardeshirpour L, Dumitru C, Dann P, Sterpka J, VanHouten J, Kim W, Kostenuik P, Wysolmerski J.

Endocrinology. 2015 Aug;156(8):2762-73. doi: 10.1210/en.2015-1232. Epub 2015 May 11.

15.

Thrombin receptor deficiency leads to a high bone mass phenotype by decreasing the RANKL/OPG ratio.

Tudpor K, van der Eerden BC, Jongwattanapisan P, Roelofs JJ, van Leeuwen JP, Bindels RJ, Hoenderop JG.

Bone. 2015 Mar;72:14-22. doi: 10.1016/j.bone.2014.11.004. Epub 2014 Nov 18.

PMID:
25460576
16.

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.

Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R.

J Clin Invest. 2006 Jun;116(6):1525-34. Epub 2006 May 4.

17.

Weaning triggers a decrease in receptor activator of nuclear factor-kappaB ligand expression, widespread osteoclast apoptosis, and rapid recovery of bone mass after lactation in mice.

Ardeshirpour L, Dann P, Adams DJ, Nelson T, VanHouten J, Horowitz MC, Wysolmerski JJ.

Endocrinology. 2007 Aug;148(8):3875-86. Epub 2007 May 10.

PMID:
17495007
18.
20.

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation.

Hyeon S, Lee H, Yang Y, Jeong W.

Free Radic Biol Med. 2013 Dec;65:789-99. doi: 10.1016/j.freeradbiomed.2013.08.005. Epub 2013 Aug 14.

PMID:
23954472

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