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Domain III regulates N-type (CaV2.2) calcium channel closing kinetics.

Yarotskyy V, Gao G, Peterson BZ, Elmslie KS.

J Neurophysiol. 2012 Apr;107(7):1942-51. doi: 10.1152/jn.00993.2011. Epub 2011 Dec 28.


Slowed N-type calcium channel (CaV2.2) deactivation by the cyclin-dependent kinase inhibitor roscovitine.

Buraei Z, Anghelescu M, Elmslie KS.

Biophys J. 2005 Sep;89(3):1681-91. Epub 2005 Jun 10.


Roscovitine differentially affects CaV2 and Kv channels by binding to the open state.

Buraei Z, Schofield G, Elmslie KS.

Neuropharmacology. 2007 Mar;52(3):883-94. Epub 2006 Nov 27.


Roscovitine inhibits CaV3.1 (T-type) channels by preferentially affecting closed-state inactivation.

Yarotskyy V, Elmslie KS.

J Pharmacol Exp Ther. 2012 Feb;340(2):463-72. doi: 10.1124/jpet.111.187104. Epub 2011 Nov 16.


Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation.

Yarotskyy V, Gao G, Du L, Ganapathi SB, Peterson BZ, Elmslie KS.

J Biol Chem. 2010 Jan 1;285(1):43-53. doi: 10.1074/jbc.M109.076448. Epub 2009 Nov 2.


Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.

Zhang Y, Chen YH, Bangaru SD, He L, Abele K, Tanabe S, Kozasa T, Yang J.

J Neurosci. 2008 Dec 24;28(52):14176-88. doi: 10.1523/JNEUROSCI.1350-08.2008.


Open-state occupancy prevents gating charge relaxation of N-type (CaV2.2) calcium channels.

Yarotskyy V, Elmslie KS.

Biophys J. 2009 Nov 4;97(9):2446-55. doi: 10.1016/j.bpj.2009.08.014.


(R)-roscovitine prolongs the mean open time of unitary N-type calcium channel currents.

DeStefino NR, Pilato AA, Dittrich M, Cherry SV, Cho S, Stiles JR, Meriney SD.

Neuroscience. 2010 May 19;167(3):838-49. doi: 10.1016/j.neuroscience.2010.02.041. Epub 2010 Feb 24.


Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Leroy J, Richards MW, Butcher AJ, Nieto-Rostro M, Pratt WS, Davies A, Dolphin AC.

J Neurosci. 2005 Jul 27;25(30):6984-96. Erratum in: J Neurosci. 2005 Oct 5;25(40):table of contents. Richards, Mark S [corrected to Richards, Mark W].


The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

Michalakis S, Zong X, Becirovic E, Hammelmann V, Wein T, Wanner KT, Biel M.

J Neurosci. 2011 Jan 5;31(1):133-41. doi: 10.1523/JNEUROSCI.4735-10.2011.


Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²⁺ channel due to a familial hemiplegic migraine mutation.

Inagaki A, Frank CA, Usachev YM, Benveniste M, Lee A.

Neuron. 2014 Jan 8;81(1):91-102. doi: 10.1016/j.neuron.2013.10.056.


G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT.

Neuron. 2005 Jun 16;46(6):891-904.


The N terminus of a schistosome beta subunit regulates inactivation and current density of a Cav2 channel.

Salvador-Recatalà V, Greenberg RM.

J Biol Chem. 2010 Nov 12;285(46):35878-88. doi: 10.1074/jbc.M110.144725. Epub 2010 Sep 7.


CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm.

Wennemuth G, Westenbroek RE, Xu T, Hille B, Babcock DF.

J Biol Chem. 2000 Jul 14;275(28):21210-7.


Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.

Luvisetto S, Fellin T, Spagnolo M, Hivert B, Brust PF, Harpold MM, Stauderman KA, Williams ME, Pietrobon D.

J Gen Physiol. 2004 Nov;124(5):445-61.


Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E.

PLoS One. 2008;3(10):e3560. doi: 10.1371/journal.pone.0003560. Epub 2008 Oct 29.


Decoding of synaptic voltage waveforms by specific classes of recombinant high-threshold Ca(2+) channels.

Liu Z, Ren J, Murphy TH.

J Physiol. 2003 Dec 1;553(Pt 2):473-88. Epub 2003 Sep 18.


The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation.

Yarotskyy V, Gao G, Peterson BZ, Elmslie KS.

J Physiol. 2009 Feb 1;587(3):551-65. doi: 10.1113/jphysiol.2008.161737. Epub 2008 Dec 15.


Alternative splicing in the C-terminus of CaV2.2 controls expression and gating of N-type calcium channels.

Castiglioni AJ, Raingo J, Lipscombe D.

J Physiol. 2006 Oct 1;576(Pt 1):119-34. Epub 2006 Jul 20.

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