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p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity.

Vaughan CA, Singh S, Windle B, Sankala HM, Graves PR, Andrew Yeudall W, Deb SP, Deb S.

Arch Biochem Biophys. 2012 Feb 1;518(1):79-88. doi: 10.1016/ Epub 2011 Dec 16.


Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.

Yeudall WA, Vaughan CA, Miyazaki H, Ramamoorthy M, Choi MY, Chapman CG, Wang H, Black E, Bulysheva AA, Deb SP, Windle B, Deb S.

Carcinogenesis. 2012 Feb;33(2):442-51. doi: 10.1093/carcin/bgr270. Epub 2011 Nov 22.


Tumor-derived p53 mutants induce NF-kappaB2 gene expression.

Scian MJ, Stagliano KE, Anderson MA, Hassan S, Bowman M, Miles MF, Deb SP, Deb S.

Mol Cell Biol. 2005 Nov;25(22):10097-110.


Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.

Vaughan CA, Pearsall I, Singh S, Windle B, Deb SP, Grossman SR, Yeudall WA, Deb S.

Oncotarget. 2016 Mar 15;7(11):12426-46. doi: 10.18632/oncotarget.6998.


Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases.

Barlev NA, Liu L, Chehab NH, Mansfield K, Harris KG, Halazonetis TD, Berger SL.

Mol Cell. 2001 Dec;8(6):1243-54.


ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

Dell'Orso S, Fontemaggi G, Stambolsky P, Goeman F, Voellenkle C, Levrero M, Strano S, Rotter V, Oren M, Blandino G.

OMICS. 2011 May;15(5):305-12. doi: 10.1089/omi.2010.0084. Epub 2011 Feb 19.


Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, Gostissa M, Dobbelstein M, Del Sal G, Piaggio G, Mantovani R.

Mol Cell Biol. 2005 May;25(9):3737-51.


Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.

Vaughan CA, Singh S, Grossman SR, Windle B, Deb SP, Deb S.

Mol Oncol. 2017 Jun;11(6):696-711. doi: 10.1002/1878-0261.12068. Epub 2017 May 8.


Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.

Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, Barsyte-Lovejoy D, Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL.

Nature. 2015 Sep 10;525(7568):206-11. doi: 10.1038/nature15251. Epub 2015 Sep 2.


BRD7 is a candidate tumour suppressor gene required for p53 function.

Drost J, Mantovani F, Tocco F, Elkon R, Comel A, Holstege H, Kerkhoven R, Jonkers J, Voorhoeve PM, Agami R, Del Sal G.

Nat Cell Biol. 2010 Apr;12(4):380-9. doi: 10.1038/ncb2038. Epub 2010 Mar 14.


p53 induces distinct epigenetic states at its direct target promoters.

Vrba L, Junk DJ, Novak P, Futscher BW.

BMC Genomics. 2008 Oct 15;9:486. doi: 10.1186/1471-2164-9-486.


Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl.

Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S.

Genes Cancer. 2012 Jul;3(7-8):491-502. doi: 10.1177/1947601912462719.


Allele specific gain-of-function activity of p53 mutants in lung cancer cells.

Vaughan CA, Frum R, Pearsall I, Singh S, Windle B, Yeudall A, Deb SP, Deb S.

Biochem Biophys Res Commun. 2012 Nov 9;428(1):6-10. doi: 10.1016/j.bbrc.2012.09.029. Epub 2012 Sep 16.


Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway.

Perez RE, Knights CD, Sahu G, Catania J, Kolukula VK, Stoler D, Graessmann A, Ogryzko V, Pishvaian M, Albanese C, Avantaggiati ML.

J Cell Physiol. 2010 Nov;225(2):394-405. doi: 10.1002/jcp.22285.


Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

Zhao Y, Lu S, Wu L, Chai G, Wang H, Chen Y, Sun J, Yu Y, Zhou W, Zheng Q, Wu M, Otterson GA, Zhu WG.

Mol Cell Biol. 2006 Apr;26(7):2782-90.


Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation.

Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, Blandino G, Piaggio G.

Cancer Cell. 2006 Sep;10(3):191-202.


The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ.

Cell Cycle. 2012 Jul 1;11(13):2458-66. doi: 10.4161/cc.20864. Epub 2012 Jul 1.


TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

Liu K, Ling S, Lin WC.

Mol Cell Biol. 2011 Nov;31(22):4464-81. doi: 10.1128/MCB.05574-11. Epub 2011 Sep 19.

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