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Items: 1 to 20 of 564

1.

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW.

Int Immunopharmacol. 2012 Feb;12(2):368-77. doi: 10.1016/j.intimp.2011.12.009. Epub 2011 Dec 22.

2.

Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.

Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun A, Snyder JP, Liotta D, Fu H.

Mol Pharmacol. 2008 Sep;74(3):654-61. doi: 10.1124/mol.108.046201. Epub 2008 Jun 24.

3.

A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies.

Bisht S, Schlesinger M, Rupp A, Schubert R, Nolting J, Wenzel J, Holdenrieder S, Brossart P, Bendas G, Feldmann G.

J Nanobiotechnology. 2016 Jul 11;14(1):57. doi: 10.1186/s12951-016-0209-6.

4.

Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.

Rajitha B, Belalcazar A, Nagaraju GP, Shaib WL, Snyder JP, Shoji M, Pattnaik S, Alam A, El-Rayes BF.

Cancer Lett. 2016 Apr 10;373(2):227-33. doi: 10.1016/j.canlet.2016.01.052. Epub 2016 Feb 2.

PMID:
26850372
5.

BDMC33, A curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways.

Lee KH, Chow YL, Sharmili V, Abas F, Alitheen NB, Shaari K, Israf DA, Lajis NH, Syahida A.

Int J Mol Sci. 2012;13(3):2985-3008. doi: 10.3390/ijms13032985. Epub 2012 Mar 6.

6.

Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts.

Zhu S, Moore TW, Lin X, Morii N, Mancini A, Howard RB, Culver D, Arrendale RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M.

Integr Biol (Camb). 2012 Jun;4(6):633-40. doi: 10.1039/c2ib20007d. Epub 2012 Apr 25.

7.

Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages.

Kim KN, Ko YJ, Kang MC, Yang HM, Roh SW, Oda T, Jeon YJ, Jung WK, Heo SJ, Yoon WJ, Kim D.

Food Chem Toxicol. 2013 Mar;53:371-5. doi: 10.1016/j.fct.2012.12.021. Epub 2012 Dec 21.

PMID:
23266270
8.

Arvelexin from Brassica rapa suppresses NF-κB-regulated pro-inflammatory gene expression by inhibiting activation of IκB kinase.

Shin JS, Noh YS, Lee YS, Cho YW, Baek NI, Choi MS, Jeong TS, Kang E, Chung HG, Lee KT.

Br J Pharmacol. 2011 Sep;164(1):145-58. doi: 10.1111/j.1476-5381.2011.01351.x.

9.

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.

PMID:
23735482
10.

The inhibition of JNK MAPK and NF-κB signaling by tenuifoliside A isolated from Polygala tenuifolia in lipopolysaccharide-induced macrophages is associated with its anti-inflammatory effect.

Kim KS, Lee DS, Bae GS, Park SJ, Kang DG, Lee HS, Oh H, Kim YC.

Eur J Pharmacol. 2013 Dec 5;721(1-3):267-76. doi: 10.1016/j.ejphar.2013.09.026. Epub 2013 Sep 27.

PMID:
24076326
11.

Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.

Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta D, Fu H.

Biochem Pharmacol. 2010 Nov 1;80(9):1309-16. doi: 10.1016/j.bcp.2010.06.048. Epub 2010 Jul 6.

12.

Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.

Lee JH, Jung HS, Giang PM, Jin X, Lee S, Son PT, Lee D, Hong YS, Lee K, Lee JJ.

J Pharmacol Exp Ther. 2006 Jan;316(1):271-8. Epub 2005 Sep 23.

13.

Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis.

Chen D, Nie M, Fan MW, Bian Z.

Pharmacology. 2008;82(4):264-9. doi: 10.1159/000161127. Epub 2008 Oct 10.

PMID:
18849645
14.

7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells.

Park HY, Kim GY, Hyun JW, Hwang HJ, Kim ND, Kim BW, Choi YH.

Int J Mol Med. 2012 Jun;29(6):1146-52. doi: 10.3892/ijmm.2012.935. Epub 2012 Mar 13.

PMID:
22427249
16.

Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages.

Jung HW, Seo UK, Kim JH, Leem KH, Park YK.

J Ethnopharmacol. 2009 Mar 18;122(2):313-9. doi: 10.1016/j.jep.2008.12.024. Epub 2008 Dec 27.

PMID:
19162159
17.

Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.

Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, Shakibaei M.

J Biol Chem. 2011 Aug 12;286(32):28556-66. doi: 10.1074/jbc.M111.256180. Epub 2011 Jun 13.

18.

Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta.

Kim BH, Roh E, Lee HY, Lee IJ, Ahn B, Jung SH, Lee H, Han SB, Kim Y.

Mol Pharmacol. 2008 Apr;73(4):1309-18. doi: 10.1124/mol.107.041251. Epub 2008 Jan 17.

19.

EF24 suppresses maturation and inflammatory response in dendritic cells.

Vilekar P, Awasthi S, Natarajan A, Anant S, Awasthi V.

Int Immunol. 2012 Jul;24(7):455-64. doi: 10.1093/intimm/dxr121. Epub 2012 Feb 29.

20.

A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages.

Zhang T, Sun L, Liu R, Zhang D, Lan X, Huang C, Xin W, Wang C, Zhang D, Du G.

Mol Pharm. 2012 Mar 5;9(3):671-7. doi: 10.1021/mp2003779. Epub 2012 Feb 15.

PMID:
22292506

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