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Items: 1 to 20 of 186


A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.

Mullen RD, Park S, Rhodes SJ.

Mol Endocrinol. 2012 Feb;26(2):308-19. doi: 10.1210/me.2011-1252. Epub 2011 Dec 22.


Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.

Park S, Mullen RD, Rhodes SJ.

Mol Endocrinol. 2013 Dec;27(12):2013-27. doi: 10.1210/me.2013-1161. Epub 2013 Oct 7.


The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic factor 1 to enhance gonadotrope-specific activity of the gonadotropin-releasing hormone receptor gene promoter.

Granger A, Bleux C, Kottler ML, Rhodes SJ, Counis R, Laverrière JN.

Mol Endocrinol. 2006 Sep;20(9):2093-108. Epub 2006 Apr 13.


LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.

Hunter CS, Malik RE, Witzmann FA, Rhodes SJ.

PLoS One. 2013 Jul 4;8(7):e68898. doi: 10.1371/journal.pone.0068898. Print 2013.


Characterization of the porcine Lhx3/LIM-3/P-Lim LIM homeodomain transcription factor.

Meier BC, Price JR, Parker GE, Bridwell JL, Rhodes SJ.

Mol Cell Endocrinol. 1999 Jan 25;147(1-2):65-74.


Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs.

Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3383-8. doi: 10.1073/pnas.1114515109. Epub 2012 Feb 16.


Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.

Sobrier ML, Attié-Bitach T, Netchine I, Encha-Razavi F, Vekemans M, Amselem S.

Gene Expr Patterns. 2004 Dec;5(2):279-84.


The role of DNA methylation in regulation of the murine Lhx3 gene.

Malik RE, Rhodes SJ.

Gene. 2014 Jan 25;534(2):272-81. doi: 10.1016/j.gene.2013.10.045. Epub 2013 Oct 31.


Expression pattern of the murine LIM class homeobox gene Lhx3 in subsets of neural and neuroendocrine tissues.

Zhadanov AB, Bertuzzi S, Taira M, Dawid IB, Westphal H.

Dev Dyn. 1995 Apr;202(4):354-64.


Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes.

Savage JJ, Hunter CS, Clark-Sturm SL, Jacob TM, Pfaeffle RW, Rhodes SJ.

Gene. 2007 Oct 1;400(1-2):44-51. Epub 2007 Jun 7.


Critical Roles of the LIM Domains of Lhx3 in Recruiting Coactivators to the Motor Neuron-Specifying Isl1-Lhx3 Complex.

Seo SY, Lee B, Lee S.

Mol Cell Biol. 2015 Oct;35(20):3579-89. doi: 10.1128/MCB.00335-15. Epub 2015 Aug 10.


A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency.

Bechtold-Dalla Pozza S, Hiedl S, Roeb J, Lohse P, Malik RE, Park S, Durán-Prado M, Rhodes SJ.

Horm Res Paediatr. 2012;77(1):41-51. doi: 10.1159/000335929. Epub 2012 Jan 26.


Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.

Mullen RD, Colvin SC, Hunter CS, Savage JJ, Walvoord EC, Bhangoo AP, Ten S, Weigel J, Pfäffle RW, Rhodes SJ.

Mol Cell Endocrinol. 2007 Feb;265-266:190-5. Epub 2007 Jan 8. Review.


Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.

Colvin SC, Malik RE, Showalter AD, Sloop KW, Rhodes SJ.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):173-8. doi: 10.1073/pnas.1009501108. Epub 2010 Dec 13.


GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene.

Schang AL, Granger A, Quérat B, Bleux C, Cohen-Tannoudji J, Laverrière JN.

Mol Endocrinol. 2013 Jan;27(1):74-91. doi: 10.1210/me.2012-1182. Epub 2012 Dec 4.


Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

Bhati M, Lee C, Gadd MS, Jeffries CM, Kwan A, Whitten AE, Trewhella J, Mackay JP, Matthews JM.

PLoS One. 2012;7(7):e40719. doi: 10.1371/journal.pone.0040719. Epub 2012 Jul 25.


Regulation of the follicle-stimulating hormone beta gene by the LHX3 LIM-homeodomain transcription factor.

West BE, Parker GE, Savage JJ, Kiratipranon P, Toomey KS, Beach LR, Colvin SC, Sloop KW, Rhodes SJ.

Endocrinology. 2004 Nov;145(11):4866-79. Epub 2004 Jul 22.


A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

Gadd MS, Jacques DA, Nisevic I, Craig VJ, Kwan AH, Guss JM, Matthews JM.

J Biol Chem. 2013 Jul 26;288(30):21924-35. doi: 10.1074/jbc.M113.478586. Epub 2013 Jun 9.

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