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Items: 1 to 20 of 87

1.

A high-throughput scintillation proximity-based assay for human DNA ligase IV.

Tseng HM, Shum D, Bhinder B, Escobar S, Veomett NJ, Tomkinson AE, Gin DY, Djaballah H, Scheinberg DA.

Assay Drug Dev Technol. 2012 Jun;10(3):235-49. doi: 10.1089/adt.2011.0404. Epub 2011 Dec 22.

2.

C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28.

PMID:
23994631
3.

Mechanisms of DNA double strand break repair and chromosome aberration formation.

Iliakis G, Wang H, Perrault AR, Boecker W, Rosidi B, Windhofer F, Wu W, Guan J, Terzoudi G, Pantelias G.

Cytogenet Genome Res. 2004;104(1-4):14-20. Review.

PMID:
15162010
4.

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.

Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.

Biochem Cell Biol. 2013 Feb;91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review.

5.

A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Cell Death Differ. 2013 Aug;20(8):1089-100. doi: 10.1038/cdd.2013.44. Epub 2013 May 31.

6.

Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.

Chiruvella KK, Renard BM, Birkeland SR, Sunder S, Liang Z, Wilson TE.

DNA Repair (Amst). 2014 Dec;24:37-45.

7.
8.

The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54.

Gorski MM, Eeken JC, de Jong AW, Klink I, Loos M, Romeijn RJ, van Veen BL, Mullenders LH, Ferro W, Pastink A.

Genetics. 2003 Dec;165(4):1929-41.

9.

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair.

Adachi N, Ishino T, Ishii Y, Takeda S, Koyama H.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12109-13.

10.

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression.

Srivastava M, Nambiar M, Sharma S, Karki SS, Goldsmith G, Hegde M, Kumar S, Pandey M, Singh RK, Ray P, Natarajan R, Kelkar M, De A, Choudhary B, Raghavan SC.

Cell. 2012 Dec 21;151(7):1474-87. doi: 10.1016/j.cell.2012.11.054.

11.

Genetic evidence for the involvement of DNA ligase IV in the DNA-PK-dependent pathway of non-homologous end joining in mammalian cells.

Wang H, Zeng ZC, Perrault AR, Cheng X, Qin W, Iliakis G.

Nucleic Acids Res. 2001 Apr 15;29(8):1653-60.

12.

Low levels of DNA ligases III and IV sufficient for effective NHEJ.

Windhofer F, Wu W, Iliakis G.

J Cell Physiol. 2007 Nov;213(2):475-83.

PMID:
17492771
13.

Delineation of key XRCC4/Ligase IV interfaces for targeted disruption of non-homologous end joining DNA repair.

McFadden MJ, Lee WK, Brennan JD, Junop MS.

Proteins. 2014 Feb;82(2):187-94. doi: 10.1002/prot.24349. Epub 2013 Sep 20.

PMID:
23794378
14.

Marked dependence on growth state of backup pathways of NHEJ.

Windhofer F, Wu W, Wang M, Singh SK, Saha J, Rosidi B, Iliakis G.

Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1462-70.

PMID:
17674976
15.

Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks.

Rothkamm K, Kühne M, Jeggo PA, Löbrich M.

Cancer Res. 2001 May 15;61(10):3886-93.

16.

Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks.

Sallmyr A, Tomkinson AE, Rassool FV.

Blood. 2008 Aug 15;112(4):1413-23. doi: 10.1182/blood-2007-07-104257. Epub 2008 Jun 4.

17.

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface.

Menchon G, Bombarde O, Trivedi M, Négrel A, Inard C, Giudetti B, Baltas M, Milon A, Modesti M, Czaplicki G, Calsou P.

Sci Rep. 2016 Mar 11;6:22878. doi: 10.1038/srep22878.

18.

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.

J Exp Med. 2010 Feb 15;207(2):417-27. doi: 10.1084/jem.20092449. Epub 2010 Feb 8. Erratum in: J Exp Med. 2013 Mar 11;210(3):641.

19.

Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity.

Wang Y, Lamarche BJ, Tsai MD.

Biochemistry. 2007 May 1;46(17):4962-76. Epub 2007 Apr 4.

PMID:
17407264
20.

DNA ligase C1 mediates the LigD-independent nonhomologous end-joining pathway of Mycobacterium smegmatis.

Bhattarai H, Gupta R, Glickman MS.

J Bacteriol. 2014 Oct;196(19):3366-76. doi: 10.1128/JB.01832-14. Epub 2014 Jun 23.

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