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Items: 1 to 20 of 107

1.

Regulating the regulator: post-translational modification of RAS.

Ahearn IM, Haigis K, Bar-Sagi D, Philips MR.

Nat Rev Mol Cell Biol. 2011 Dec 22;13(1):39-51. doi: 10.1038/nrm3255. Review.

2.

Control of Ras cycling by Ca2+.

Walker SA, Cullen PJ, Taylor JA, Lockyer PJ.

FEBS Lett. 2003 Jul 3;546(1):6-10. Review.

3.

The Ras binary switch: an ideal processor for decoding complex Ca2+ signals?

Walker SA, Lockyer PJ, Cullen PJ.

Biochem Soc Trans. 2003 Oct;31(Pt 5):966-9. Review.

PMID:
14505461
4.

The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.

Schöpel M, Potheraveedu VN, Al-Harthy T, Abdel-Jalil R, Heumann R, Stoll R.

Biol Chem. 2017 May 1;398(5-6):577-588. doi: 10.1515/hsz-2016-0276. Review.

PMID:
28475102
5.

Guanine nucleotide exchange factors: activators of Ras superfamily proteins.

Overbeck AF, Brtva TR, Cox AD, Graham SM, Huff SY, Khosravi-Far R, Quilliam LA, Solski PA, Der CJ.

Mol Reprod Dev. 1995 Dec;42(4):468-76. Review.

PMID:
8607978
6.

Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.

Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF.

J Biol Chem. 2000 Oct 13;275(41):32260-7.

7.

Mechanism of the guanine nucleotide exchange reaction of Ras GTPase--evidence for a GTP/GDP displacement model.

Zhang B, Zhang Y, Shacter E, Zheng Y.

Biochemistry. 2005 Feb 22;44(7):2566-76.

PMID:
15709769
8.
9.

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Vigil D, Cherfils J, Rossman KL, Der CJ.

Nat Rev Cancer. 2010 Dec;10(12):842-57. doi: 10.1038/nrc2960. Epub 2010 Nov 24. Review.

10.
11.

Regulation of small GTPases by GEFs, GAPs, and GDIs.

Cherfils J, Zeghouf M.

Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. Review.

12.

GEFs and GAPs: critical elements in the control of small G proteins.

Bos JL, Rehmann H, Wittinghofer A.

Cell. 2007 Jun 1;129(5):865-77. Review. Erratum in: Cell. 2007 Jul 27;130(2):385.

13.

Ras activation revisited: role of GEF and GAP systems.

Hennig A, Markwart R, Esparza-Franco MA, Ladds G, Rubio I.

Biol Chem. 2015 Aug;396(8):831-48. doi: 10.1515/hsz-2014-0257. Review.

PMID:
25781681
14.

The Ras GDP/GTP cycle is regulated by oxidizing agents at the level of Ras regulators and effectors.

Accorsi K, Giglione C, Vanoni M, Parmeggiani A.

FEBS Lett. 2001 Mar 9;492(1-2):139-45.

15.

GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins.

Geyer M, Wittinghofer A.

Curr Opin Struct Biol. 1997 Dec;7(6):786-92. Review.

PMID:
9434896
16.

GTPases and T cell activation.

Cantrell DA.

Immunol Rev. 2003 Apr;192:122-30. Review.

PMID:
12670400
17.

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

Gotoh T, Cai D, Tian X, Feig LA, Lerner A.

J Biol Chem. 2000 Sep 29;275(39):30118-23.

18.

Post-translational modifications of Ras and Ral are important for the action of Ral GDP dissociation stimulator.

Hinoi T, Kishida S, Koyama S, Ikeda M, Matsuura Y, Kikuchi A.

J Biol Chem. 1996 Aug 16;271(33):19710-6.

19.

The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.

Boissier P, Huynh-Do U.

Cell Signal. 2014 Mar;26(3):483-91. doi: 10.1016/j.cellsig.2013.11.034. Epub 2013 Dec 2. Review.

PMID:
24308970
20.

Effect on the Ras/Raf signaling pathway of post-translational modifications of neurofibromin: in silico study of protein modification responsible for regulatory pathways.

Nasir-ud-Din, Kaleem A, Ahmad I, Walker-Nasir E, Hoessli DC, Shakoori AR.

J Cell Biochem. 2009 Nov 1;108(4):816-24. doi: 10.1002/jcb.22301.

PMID:
19718661

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