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Items: 1 to 20 of 71

1.

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice.

Selman C, Partridge L.

Cell Cycle. 2012 Jan 1;11(1):17-8. doi: 10.4161/cc.11.1.18736. Epub 2012 Jan 1. No abstract available.

PMID:
22186783
2.

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Rosenfeld SV, Blagosklonny MV.

Cell Cycle. 2011 Dec 15;10(24):4230-6. doi: 10.4161/cc.10.24.18486. Epub 2011 Dec 15.

PMID:
22107964
3.

Rapamycin slows aging in mice.

Spong A, Bartke A.

Cell Cycle. 2012 Mar 1;11(5):845. doi: 10.4161/cc.11.5.19607. Epub 2012 Mar 1. No abstract available.

PMID:
22356747
4.

Rapamycin for life: a step to immortality.

Demidenko ZN.

Cell Cycle. 2011 Dec 15;10(24):4206. doi: 10.4161/cc.10.24.18562. Epub 2011 Dec 15. No abstract available.

PMID:
22107962
5.

Rapamycin extends murine lifespan but has limited effects on aging.

Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D.

J Clin Invest. 2013 Aug;123(8):3272-91. doi: 10.1172/JCI67674. Epub 2013 Jul 25.

6.

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.

Komarova EA, Antoch MP, Novototskaya LR, Chernova OB, Paszkiewicz G, Leontieva OV, Blagosklonny MV, Gudkov AV.

Aging (Albany NY). 2012 Oct;4(10):709-14.

7.

Rapamycin extends life- and health span because it slows aging.

Blagosklonny MV.

Aging (Albany NY). 2013 Aug;5(8):592-8.

8.

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA.

Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.

9.

Rapamycin, anti-aging, and avoiding the fate of Tithonus.

Richardson A.

J Clin Invest. 2013 Aug;123(8):3204-6.

10.

Rapamycin slows aging in mice.

Wilkinson JE, Burmeister L, Brooks SV, Chan CC, Friedline S, Harrison DE, Hejtmancik JF, Nadon N, Strong R, Wood LK, Woodward MA, Miller RA.

Aging Cell. 2012 Aug;11(4):675-82. doi: 10.1111/j.1474-9726.2012.00832.x. Epub 2012 Jun 4.

11.

Rapamycin extends maximal lifespan in cancer-prone mice.

Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV.

Am J Pathol. 2010 May;176(5):2092-7. doi: 10.2353/ajpath.2010.091050. Epub 2010 Apr 2.

12.

Rapamycin and quasi-programmed aging: four years later.

Blagosklonny MV.

Cell Cycle. 2010 May 15;9(10):1859-62. Epub 2010 May 15. Review.

PMID:
20436272
13.

Late-life rapamycin treatment reverses age-related heart dysfunction.

Flynn JM, O'Leary MN, Zambataro CA, Academia EC, Presley MP, Garrett BJ, Zykovich A, Mooney SD, Strong R, Rosen CJ, Kapahi P, Nelson MD, Kennedy BK, Melov S.

Aging Cell. 2013 Oct;12(5):851-62. doi: 10.1111/acel.12109. Epub 2013 Jul 7.

14.

Resveratrol and rapamycin: are they anti-aging drugs?

Kaeberlein M.

Bioessays. 2010 Feb;32(2):96-9. doi: 10.1002/bies.200900171.

PMID:
20091754
15.

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R.

J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25.

16.

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.

Popovich IG, Anisimov VN, Zabezhinski MA, Semenchenko AV, Tyndyk ML, Yurova MN, Blagosklonny MV.

Cancer Biol Ther. 2014 May;15(5):586-92. doi: 10.4161/cbt.28164. Epub 2014 Feb 20.

17.

Pet dogs set to test anti-ageing drug.

Check Hayden E.

Nature. 2014 Oct 30;514(7524):546. doi: 10.1038/514546a. No abstract available.

PMID:
25355339
18.

Ageing: A midlife longevity drug?

Kaeberlein M, Kennedy BK.

Nature. 2009 Jul 16;460(7253):331-2. doi: 10.1038/460331a. Epub 2009 Jul 8. No abstract available.

PMID:
19606132
19.

An anti-aging drug today: from senescence-promoting genes to anti-aging pill.

Blagosklonny MV.

Drug Discov Today. 2007 Mar;12(5-6):218-24. Epub 2007 Feb 9. Review.

PMID:
17331886
20.

Rapamycin in aging and disease: maximizing efficacy while minimizing side effects.

Johnson SC, Kaeberlein M.

Oncotarget. 2016 Jul 19;7(29):44876-44878. doi: 10.18632/oncotarget.10381.

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