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Items: 1 to 20 of 193

1.

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

Berger A, Sommer AF, Zwarg J, Hamdorf M, Welzel K, Esly N, Panitz S, Reuter A, Ramos I, Jatiani A, Mulder LC, Fernandez-Sesma A, Rutsch F, Simon V, König R, Flory E.

PLoS Pathog. 2011 Dec;7(12):e1002425. doi: 10.1371/journal.ppat.1002425. Epub 2011 Dec 8.

2.

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT.

Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964.

3.

Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.

Powell RD, Holland PJ, Hollis T, Perrino FW.

J Biol Chem. 2011 Dec 23;286(51):43596-600. doi: 10.1074/jbc.C111.317628. Epub 2011 Nov 7.

4.

The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.

Morrissey C, Schwefel D, Ennis-Adeniran V, Taylor IA, Crow YJ, Webb M.

Biochem J. 2015 Feb 15;466(1):69-76. doi: 10.1042/BJ20140203.

PMID:
25423367
5.

SAMHD1-dependent retroviral control and escape in mice.

Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, Reis e Sousa C.

EMBO J. 2013 Sep 11;32(18):2454-62. doi: 10.1038/emboj.2013.163. Epub 2013 Jul 19.

6.

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.

Goncalves A, Karayel E, Rice GI, Bennett KL, Crow YJ, Superti-Furga G, Bürckstümmer T.

Hum Mutat. 2012 Jul;33(7):1116-22. doi: 10.1002/humu.22087. Epub 2012 Apr 16.

PMID:
22461318
7.

SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.

Sze A, Olagnier D, Lin R, van Grevenynghe J, Hiscott J.

J Mol Biol. 2013 Dec 13;425(24):4981-94. doi: 10.1016/j.jmb.2013.10.022. Epub 2013 Oct 23. Review.

PMID:
24161438
8.

SAMHD1: a novel antiviral factor in intrinsic immunity.

Chen Z, Zhang L, Ying S.

Future Microbiol. 2012 Sep;7(9):1117-26. doi: 10.2217/fmb.12.81. Review.

PMID:
22953710
9.

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.

Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M.

Nature. 2011 May 25;474(7353):654-7. doi: 10.1038/nature10117.

10.

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

Zhao K, Du J, Han X, Goodier JL, Li P, Zhou X, Wei W, Evans SL, Li L, Zhang W, Cheung LE, Wang G, Kazazian HH Jr, Yu XF.

Cell Rep. 2013 Sep 26;4(6):1108-15. doi: 10.1016/j.celrep.2013.08.019. Epub 2013 Sep 12.

11.

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.

Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim SY, Seo D, Kim J, White TE, Brandariz-Nuñez A, Diaz-Griffero F, Yun CH, Hollenbaugh JA, Kim B, Baek D, Ahn K.

Nat Med. 2014 Aug;20(8):936-41. doi: 10.1038/nm.3626. Epub 2014 Jul 20.

12.

Restricted access to myeloid cells explained.

Planelles V.

Viruses. 2011 Sep;3(9):1624-33. doi: 10.3390/v3091624. Epub 2011 Sep 5.

13.

SAMHD1 prevents autoimmunity by maintaining genome stability.

Kretschmer S, Wolf C, König N, Staroske W, Guck J, Häusler M, Luksch H, Nguyen LA, Kim B, Alexopoulou D, Dahl A, Rapp A, Cardoso MC, Shevchenko A, Lee-Kirsch MA.

Ann Rheum Dis. 2015 Mar;74(3):e17. doi: 10.1136/annrheumdis-2013-204845. Epub 2014 Jan 20.

14.

Polymorphisms of the SAMHD1 gene are not associated with the infection and natural control of HIV type 1 in Europeans and African-Americans.

Coon S, Wang D, Wu L.

AIDS Res Hum Retroviruses. 2012 Dec;28(12):1565-73. doi: 10.1089/AID.2012.0039. Epub 2012 Jun 1.

15.

SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.

Zhang R, Bloch N, Nguyen LA, Kim B, Landau NR.

PLoS One. 2014 Feb 19;9(2):e89558. doi: 10.1371/journal.pone.0089558. eCollection 2014.

16.

Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome.

Kasher PR, Jenkinson EM, Briolat V, Gent D, Morrissey C, Zeef LA, Rice GI, Levraud JP, Crow YJ.

J Immunol. 2015 Mar 15;194(6):2819-25. doi: 10.4049/jimmunol.1403157. Epub 2015 Feb 11.

17.

Single-stranded nucleic acids promote SAMHD1 complex formation.

Tüngler V, Staroske W, Kind B, Dobrick M, Kretschmer S, Schmidt F, Krug C, Lorenz M, Chara O, Schwille P, Lee-Kirsch MA.

J Mol Med (Berl). 2013 Jun;91(6):759-70. doi: 10.1007/s00109-013-0995-3. Epub 2013 Jan 31.

PMID:
23371319
18.

Restricting HIV the SAMHD1 way: through nucleotide starvation.

Ayinde D, Casartelli N, Schwartz O.

Nat Rev Microbiol. 2012 Oct;10(10):675-80. doi: 10.1038/nrmicro2862. Epub 2012 Aug 28. Review.

PMID:
22926205
19.

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

Rice GI, Forte GM, Szynkiewicz M, Chase DS, Aeby A, Abdel-Hamid MS, Ackroyd S, Allcock R, Bailey KM, Balottin U, Barnerias C, Bernard G, Bodemer C, Botella MP, Cereda C, Chandler KE, Dabydeen L, Dale RC, De Laet C, De Goede CG, Del Toro M, Effat L, Enamorado NN, Fazzi E, Gener B, Haldre M, Lin JP, Livingston JH, Lourenco CM, Marques W Jr, Oades P, Peterson P, Rasmussen M, Roubertie A, Schmidt JL, Shalev SA, Simon R, Spiegel R, Swoboda KJ, Temtamy SA, Vassallo G, Vilain CN, Vogt J, Wermenbol V, Whitehouse WP, Soler D, Olivieri I, Orcesi S, Aglan MS, Zaki MS, Abdel-Salam GM, Vanderver A, Kisand K, Rozenberg F, Lebon P, Crow YJ.

Lancet Neurol. 2013 Dec;12(12):1159-69. doi: 10.1016/S1474-4422(13)70258-8. Epub 2013 Oct 30.

20.

Degradation of SAMHD1 by Vpx Is Independent of Uncoating.

Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR.

J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11.

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