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Items: 1 to 20 of 163

1.

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction.

Stojković V, Perissinotti LL, Willmer D, Benkovic SJ, Kohen A.

J Am Chem Soc. 2012 Jan 25;134(3):1738-45. doi: 10.1021/ja209425w. Epub 2012 Jan 17.

2.

Free energy simulations of active-site mutants of dihydrofolate reductase.

Doron D, Stojković V, Gakhar L, Vardi-Kilshtain A, Kohen A, Major DT.

J Phys Chem B. 2015 Jan 22;119(3):906-16. doi: 10.1021/jp5059963. Epub 2014 Nov 21.

PMID:
25382260
3.

The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase.

Francis K, Sapienza PJ, Lee AL, Kohen A.

Biochemistry. 2016 Feb 23;55(7):1100-6. doi: 10.1021/acs.biochem.5b00945. Epub 2016 Feb 9.

4.

Preservation of protein dynamics in dihydrofolate reductase evolution.

Francis K, Stojkovic V, Kohen A.

J Biol Chem. 2013 Dec 13;288(50):35961-8. doi: 10.1074/jbc.M113.507632. Epub 2013 Oct 24.

5.

Effects of a distal mutation on active site chemistry.

Wang L, Tharp S, Selzer T, Benkovic SJ, Kohen A.

Biochemistry. 2006 Feb 7;45(5):1383-92.

6.

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.

Wang L, Goodey NM, Benkovic SJ, Kohen A.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15753-8. Epub 2006 Oct 10.

7.

The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.

Stojković V, Perissinotti LL, Lee J, Benkovic SJ, Kohen A.

Chem Commun (Camb). 2010 Dec 21;46(47):8974-6. doi: 10.1039/c0cc02988b. Epub 2010 Oct 25.

8.

Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.

Swanwick RS, Maglia G, Tey LH, Allemann RK.

Biochem J. 2006 Feb 15;394(Pt 1):259-65.

9.

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.

Wang L, Goodey NM, Benkovic SJ, Kohen A.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1307-15.

10.

Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations.

Hammes-Schiffer S, Watney JB.

Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1365-73.

12.

Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.

Loveridge EJ, Tey LH, Allemann RK.

J Am Chem Soc. 2010 Jan 27;132(3):1137-43. doi: 10.1021/ja909353c.

PMID:
20047317
13.

Impact of distal mutations on the network of coupled motions correlated to hydride transfer in dihydrofolate reductase.

Wong KF, Selzer T, Benkovic SJ, Hammes-Schiffer S.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6807-12. Epub 2005 Apr 5.

14.

Comparison of coupled motions in Escherichia coli and Bacillus subtilis dihydrofolate reductase.

Watney JB, Hammes-Schiffer S.

J Phys Chem B. 2006 May 25;110(20):10130-8.

PMID:
16706474
16.

Connecting protein conformational dynamics with catalytic function as illustrated in dihydrofolate reductase.

Fan Y, Cembran A, Ma S, Gao J.

Biochemistry. 2013 Mar 26;52(12):2036-49. doi: 10.1021/bi301559q. Epub 2013 Jan 16.

17.

Steric effects on the primary isotope dependence of secondary kinetic isotope effects in hydride transfer reactions in solution: caused by the isotopically different tunneling ready state conformations?

Maharjan B, Raghibi Boroujeni M, Lefton J, White OR, Razzaghi M, Hammann BA, Derakhshani-Molayousefi M, Eilers JE, Lu Y.

J Am Chem Soc. 2015 May 27;137(20):6653-61. doi: 10.1021/jacs.5b03085. Epub 2015 May 15.

PMID:
25941865
18.

The role of the Met20 loop in the hydride transfer in Escherichia coli dihydrofolate reductase.

Mhashal AR, Vardi-Kilshtain A, Kohen A, Major DT.

J Biol Chem. 2017 Aug 25;292(34):14229-14239. doi: 10.1074/jbc.M117.777136. Epub 2017 Jun 15.

PMID:
28620051
19.

Network of remote and local protein dynamics in dihydrofolate reductase catalysis.

Singh P, Francis K, Kohen A.

ACS Catal. 2015 May 1;5(5):3067-3073. Epub 2015 Apr 8.

20.

The role of large-scale motions in catalysis by dihydrofolate reductase.

Loveridge EJ, Tey LH, Behiry EM, Dawson WM, Evans RM, Whittaker SB, Günther UL, Williams C, Crump MP, Allemann RK.

J Am Chem Soc. 2011 Dec 21;133(50):20561-70. doi: 10.1021/ja208844j. Epub 2011 Nov 22.

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