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Items: 1 to 20 of 92

1.

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É.

ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13.

PMID:
22170700
2.

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É.

J Med Chem. 2015 Mar 12;58(5):2431-40. doi: 10.1021/jm501916k. Epub 2015 Feb 24.

PMID:
25668242
3.

Evaluation of novel cyclic analogues of apelin.

Hamada J, Kimura J, Ishida J, Kohda T, Morishita S, Ichihara S, Fukamizu A.

Int J Mol Med. 2008 Oct;22(4):547-52.

PMID:
18813863
4.

Structural insight into G-protein coupled receptor binding by apelin.

Langelaan DN, Bebbington EM, Reddy T, Rainey JK.

Biochemistry. 2009 Jan 27;48(3):537-48. doi: 10.1021/bi801864b.

PMID:
19123778
5.

Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure.

El Messari S, Iturrioz X, Fassot C, De Mota N, Roesch D, Llorens-Cortes C.

J Neurochem. 2004 Sep;90(6):1290-301.

6.

Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.

Moon MJ, Oh DY, Moon JS, Kim DK, Hwang JI, Lee JY, Kim JI, Cho S, Kwon HB, Seong JY.

Mol Cell Endocrinol. 2007 Oct 15;277(1-2):51-60. Epub 2007 Aug 2.

PMID:
17825479
7.

Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ.

Fan X, Zhou N, Zhang X, Mukhtar M, Lu Z, Fang J, DuBois GC, Pomerantz RJ.

Biochemistry. 2003 Sep 2;42(34):10163-8.

PMID:
12939143
8.

Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.

Chen X, Bai B, Tian Y, Du H, Chen J.

J Biol Chem. 2014 Nov 7;289(45):31173-87. doi: 10.1074/jbc.M114.574020. Epub 2014 Sep 30.

9.

By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

Iturrioz X, Gerbier R, Leroux V, Alvear-Perez R, Maigret B, Llorens-Cortes C.

J Biol Chem. 2010 Oct 15;285(42):32627-37. doi: 10.1074/jbc.M110.127167. Epub 2010 Jul 30.

10.

G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility.

Hashimoto Y, Ishida J, Yamamoto R, Fujiwara K, Asada S, Kasuya Y, Mochizuki N, Fukamizu A.

Int J Mol Med. 2005 Nov;16(5):787-92.

PMID:
16211245
11.

Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin.

Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, Kitada C, Honda S, Kurokawa T, Onda H, Nishimura O, Fujino M.

J Biol Chem. 2000 Jul 14;275(28):21061-7.

12.

Exploring the 'RPRL' motif of apelin-13 through molecular simulation and biological evaluation of cyclic peptide analogues.

Macaluso NJ, Glen RC.

ChemMedChem. 2010 Aug 2;5(8):1247-53. doi: 10.1002/cmdc.201000061. No abstract available.

PMID:
20486151
13.

Discovery of a competitive apelin receptor (APJ) antagonist.

Macaluso NJ, Pitkin SL, Maguire JJ, Davenport AP, Glen RC.

ChemMedChem. 2011 Jun 6;6(6):1017-23. doi: 10.1002/cmdc.201100069. Epub 2011 May 10.

PMID:
21560248
14.

Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways.

Cui RR, Mao DA, Yi L, Wang C, Zhang XX, Xie H, Wu XP, Liao XB, Zhou H, Meng JC, Yuan LQ, Liao EY.

Amino Acids. 2010 Nov;39(5):1193-200. doi: 10.1007/s00726-010-0555-x. Epub 2010 May 22.

PMID:
20495838
15.

The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment.

Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.

Pharmacol Res. 2018 May;131:7-16. doi: 10.1016/j.phrs.2018.02.032. Epub 2018 Mar 9.

PMID:
29530600
16.

Amino-terminal parathyroid hormone fragment analogs containing alpha,alpha-di-alkyl amino acids at positions 1 and 3.

Shimizu N, Dean T, Khatri A, Gardella TJ.

J Bone Miner Res. 2004 Dec;19(12):2078-86. Epub 2004 Sep 20.

17.

Identifying structural determinants of potency for analogs of apelin-13: integration of C-terminal truncation with structure-activity.

Zhang Y, Maitra R, Harris DL, Dhungana S, Snyder R, Runyon SP.

Bioorg Med Chem. 2014 Jun 1;22(11):2992-7. doi: 10.1016/j.bmc.2014.04.001. Epub 2014 Apr 13.

PMID:
24755525
18.

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.

Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M.

Biochem Biophys Res Commun. 1998 Oct 20;251(2):471-6.

PMID:
9792798
19.

Emerging roles of apelin in biology and medicine.

Kleinz MJ, Davenport AP.

Pharmacol Ther. 2005 Aug;107(2):198-211. Review.

PMID:
15907343
20.

GPCR structure and function relationship: identification of a biased apelin receptor mutant.

Ban T, Li X, Ma X, Yang H, Song Y, Sun Y, Shen M, Li N, Zhang MY, Ma Y, Zhong W, Zhang M, Hu LA.

Biochem J. 2018 Dec 6;475(23):3813-3826. doi: 10.1042/BCJ20180740.

PMID:
30409826

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