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Items: 1 to 20 of 87

1.

Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.

Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE.

J Biol Chem. 2012 Feb 10;287(7):4894-903. doi: 10.1074/jbc.M111.315242.

2.

Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43. doi: 10.1073/pnas.0904064106.

3.

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid.

Albarqi MM, Stoltzfus JD, Pilgrim AA, Nolan TJ, Wang Z, Kliewer SA, Mangelsdorf DJ, Lok JB.

PLoS Pathog. 2016 Jan 4;12(1):e1005358. doi: 10.1371/journal.ppat.1005358.

4.

A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes.

Ogawa A, Streit A, Antebi A, Sommer RJ.

Curr Biol. 2009 Jan 13;19(1):67-71. doi: 10.1016/j.cub.2008.11.063.

5.

DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid.

Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS.

Aging Cell. 2006 Aug;5(4):283-91.

6.

Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.

Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ.

Mol Endocrinol. 2009 May;23(5):640-8. doi: 10.1210/me.2008-0415.

7.

Structural and functional characterisation of the fork head transcription factor-encoding gene, Hc-daf-16, from the parasitic nematode Haemonchus contortus (Strongylida).

Hu M, Lok JB, Ranjit N, Massey HC Jr, Sternberg PW, Gasser RB.

Int J Parasitol. 2010 Mar 15;40(4):405-15. doi: 10.1016/j.ijpara.2009.09.005.

8.

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.

Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5014-9.

9.

Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution.

Bento G, Ogawa A, Sommer RJ.

Nature. 2010 Jul 22;466(7305):494-7. doi: 10.1038/nature09164.

PMID:
20592728
10.

Molecular cloning and DNA binding characterization of DAF-16 orthologs from Ancylostoma hookworms.

Gao X, Frank D, Hawdon JM.

Int J Parasitol. 2009 Mar;39(4):407-15. doi: 10.1016/j.ijpara.2008.09.005.

11.

Identification of a DAF-7 ortholog from the hookworm Ancylostoma caninum.

Brand AM, Varghese G, Majewski W, Hawdon JM.

Int J Parasitol. 2005 Dec;35(14):1489-98.

PMID:
16135366
12.

Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle.

Dansey MV, Alvarez LD, Samaja G, Escudero DS, Veleiro AS, Pecci A, Castro OA, Burton G.

Biochem J. 2015 Jan 1;465(1):175-84. doi: 10.1042/BJ20140833.

PMID:
25374049
13.

Molecular cloning and characterization of a nematode polyprotein antigen/allergen from the human and animal hookworm Ancylostoma ceylanicum.

Fairfax KC, Harrison LM, Cappello M.

Mol Biochem Parasitol. 2014 Nov;198(1):37-44. doi: 10.1016/j.molbiopara.2014.11.005.

14.

The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans.

Magner DB, Wollam J, Shen Y, Hoppe C, Li D, Latza C, Rottiers V, Hutter H, Antebi A.

Cell Metab. 2013 Aug 6;18(2):212-24. doi: 10.1016/j.cmet.2013.07.007.

15.

Steroids as central regulators of organismal development and lifespan.

Lee SS, Schroeder FC.

PLoS Biol. 2012;10(4):e1001307. doi: 10.1371/journal.pbio.1001307.

16.

Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid.

Martin R, Däbritz F, Entchev EV, Kurzchalia TV, Knölker HJ.

Org Biomol Chem. 2008 Dec 7;6(23):4293-5. doi: 10.1039/b815064h.

PMID:
19005586
17.

Characterisation of hookworm heat shock factor binding protein (HSB-1) during heat shock and larval activation.

Krepp J, Gelmedin V, Hawdon JM.

Int J Parasitol. 2011 Apr;41(5):533-43. doi: 10.1016/j.ijpara.2010.12.001.

18.

Failure of Parastrongyloides trichosuri daf-7 to complement a Caenorhabditis elegans daf-7 (e1372) mutant: implications for the evolution of parasitism.

Crook M, Grant K, Grant WN.

Int J Parasitol. 2010 Dec;40(14):1675-83. doi: 10.1016/j.ijpara.2010.07.003.

PMID:
20673766
19.

Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling.

Dumas KJ, Guo C, Shih HJ, Hu PJ.

G3 (Bethesda). 2013 May 20;3(5):841-50. doi: 10.1534/g3.112.005116.

20.

The Caenorhabditis elegans DAF-12 nuclear receptor: structure, dynamics, and interaction with ligands.

Alvarez LD, Mañez PA, Estrin DA, Burton G.

Proteins. 2012 Jul;80(7):1798-809. doi: 10.1002/prot.24076.

PMID:
22489014
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